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    Dusp1 dual specificity phosphatase 1 [ Mus musculus (house mouse) ]

    Gene ID: 19252, updated on 22-Aug-2021

    Summary

    Official Symbol
    Dusp1provided by MGI
    Official Full Name
    dual specificity phosphatase 1provided by MGI
    Primary source
    MGI:MGI:105120
    See related
    Ensembl:ENSMUSG00000024190
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    e; MKP; Ptp; erp; MKP1; mkp-; mkp-1; 3CH134; Ptpn16; U19515
    Expression
    Ubiquitous expression in lung adult (RPKM 117.9), heart adult (RPKM 43.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Dusp1 in Genome Data Viewer
    Location:
    17 A3.3; 17 13.28 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26724565..26727446, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26505591..26508472, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (26642536..26645417, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene neuralized E3 ubiquitin protein ligase 1B Neighboring gene predicted gene, 34455 Neighboring gene RIKEN cDNA 1700049J03 gene Neighboring gene predicted gene, 34606 Neighboring gene ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables MAP kinase tyrosine/serine/threonine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitogen-activated protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mitogen-activated protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine/serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein tyrosine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to chemokine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endoderm formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of p38MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-threonine dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-tyrosine dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-tyrosine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dual specificity protein phosphatase 1
    Names
    MAP kinase phosphatase 1
    mitogen-activated protein kinase phosphatase-1
    protein tyrosine phosphatase, non-receptor type 16
    protein-tyrosine phosphatase 3CH134
    protein-tyrosine phosphatase ERP
    NP_038670.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013642.3NP_038670.1  dual specificity protein phosphatase 1

      See identical proteins and their annotated locations for NP_038670.1

      Status: VALIDATED

      Source sequence(s)
      AK159251, U19515
      Consensus CDS
      CCDS28552.1
      UniProtKB/Swiss-Prot
      P28563
      UniProtKB/TrEMBL
      Q3U8K3
      Related
      ENSMUSP00000025025.7, ENSMUST00000025025.7
      Conserved Domains (3) summary
      COG2453
      Location:188313
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      cd00127
      Location:173309
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      cd01446
      Location:7136
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      26724565..26727446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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