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    Psme3 proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) [ Mus musculus (house mouse) ]

    Gene ID: 19192, updated on 2-Aug-2021

    Summary

    Official Symbol
    Psme3provided by MGI
    Official Full Name
    proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)provided by MGI
    Primary source
    MGI:MGI:1096366
    See related
    Ensembl:ENSMUSG00000078652
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    K; Ki; pa2; REGga; pa28g; AA410043; AU020960; REGgamma; PA28gamma
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 81.8), liver E14 (RPKM 74.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Psme3 in Genome Data Viewer
    Location:
    11 D; 11 64.67 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101206090..101214363)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101316213..101323537)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (101177565..101184845)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene cytochrome C oxidase assembly factor 3 Neighboring gene cyclin N-terminal domain containing 1 Neighboring gene beclin 1, autophagy related Neighboring gene amine oxidase, copper containing 2 (retina-specific) Neighboring gene amine oxidase, copper containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MDM2/MDM4 family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables endopeptidase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables endopeptidase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of proteasome activator complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    proteasome activator complex subunit 3
    Names
    11S regulator complex subunit gamma
    REG-gamma
    activator of multicatalytic protease subunit 3
    ki nuclear autoantigen
    proteaseome (prosome, macropain) 28 subunit, 3
    proteasome activator 28 subunit gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011192.4NP_035322.1  proteasome activator complex subunit 3

      See identical proteins and their annotated locations for NP_035322.1

      Status: VALIDATED

      Source sequence(s)
      AK140597, AW490477, BF456075, BY324327
      Consensus CDS
      CCDS25463.1
      UniProtKB/Swiss-Prot
      P61290
      UniProtKB/TrEMBL
      Q4FK54
      Related
      ENSMUSP00000019470.8, ENSMUST00000019470.14
      Conserved Domains (2) summary
      pfam02251
      Location:969
      PA28_alpha; Proteasome activator pa28 alpha subunit
      pfam02252
      Location:109251
      PA28_beta; Proteasome activator pa28 beta subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      101206090..101214363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156432.1XP_036012325.1  proteasome activator complex subunit 3 isoform X3

      Conserved Domains (2) summary
      pfam02251
      Location:946
      PA28_alpha; Proteasome activator pa28 alpha subunit
      pfam02252
      Location:74216
      PA28_beta; Proteasome activator pa28 beta subunit
    2. XM_030245676.1XP_030101536.1  proteasome activator complex subunit 3 isoform X1

      Conserved Domains (2) summary
      pfam02251
      Location:2580
      PA28_alpha; Proteasome activator pa28 alpha subunit
      pfam02252
      Location:119263
      PA28_beta; Proteasome activator pa28 beta subunit
    3. XM_036156431.1XP_036012324.1  proteasome activator complex subunit 3 isoform X2

      Conserved Domains (2) summary
      pfam02251
      Location:2567
      PA28_alpha; Proteasome activator pa28 alpha subunit
      pfam02252
      Location:85227
      PA28_beta; Proteasome activator pa28 beta subunit
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