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    Psme3 proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) [ Mus musculus (house mouse) ]

    Gene ID: 19192, updated on 9-Sep-2018

    Summary

    Official Symbol
    Psme3provided by MGI
    Official Full Name
    proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)provided by MGI
    Primary source
    MGI:MGI:1096366
    See related
    Ensembl:ENSMUSG00000078652 Vega:OTTMUSG00000002795
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ki; pa28g; AA410043; AU020960; REGgamma; PA28gamma
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 81.8), liver E14 (RPKM 74.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Psme3 in Genome Data Viewer
    Location:
    11 D; 11 64.67 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (101316251..101323531)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (101177565..101184845)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene cytochrome C oxidase assembly factor 3 Neighboring gene cyclin N-terminal domain containing 1 Neighboring gene beclin 1, autophagy related Neighboring gene amine oxidase, copper containing 2 (retina-specific) Neighboring gene amine oxidase, copper containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    MDM2/MDM4 family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    endopeptidase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endopeptidase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of proteasomal protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    proteasome activator complex IEA
    Inferred from Electronic Annotation
    more info
     
    proteasome complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    proteasome activator complex subunit 3
    Names
    11S regulator complex subunit gamma
    REG-gamma
    activator of multicatalytic protease subunit 3
    ki nuclear autoantigen
    proteaseome (prosome, macropain) 28 subunit, 3
    proteasome activator 28 subunit gamma

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011192.4NP_035322.1  proteasome activator complex subunit 3

      See identical proteins and their annotated locations for NP_035322.1

      Status: VALIDATED

      Source sequence(s)
      AK140597, AW490477, BF456075, BY324327
      Consensus CDS
      CCDS25463.1
      UniProtKB/Swiss-Prot
      P61290
      UniProtKB/TrEMBL
      Q4FK54
      Related
      ENSMUSP00000019470.7, OTTMUSP00000002694, ENSMUST00000019470.13
      Conserved Domains (2) summary
      pfam02251
      Location:1268
      PA28_alpha; Proteasome activator pa28 alpha subunit
      pfam02252
      Location:108252
      PA28_beta; Proteasome activator pa28 beta subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      101316251..101323531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532525.3XP_006532588.1  proteasome activator complex subunit 3 isoform X1

      Conserved Domains (2) summary
      pfam02251
      Location:2579
      PA28_alpha; Proteasome activator pa28 alpha subunit
      pfam02252
      Location:122263
      PA28_beta; Proteasome activator pa28 beta subunit
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