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    Pkm pyruvate kinase, muscle [ Mus musculus (house mouse) ]

    Gene ID: 18746, updated on 2-Oct-2018

    Summary

    Official Symbol
    Pkmprovided by MGI
    Official Full Name
    pyruvate kinase, muscleprovided by MGI
    Primary source
    MGI:MGI:97591
    See related
    Ensembl:ENSMUSG00000032294 Vega:OTTMUSG00000063298
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pk3; Pk-2; Pk-3; Pkm2; AA414905; AL024370; AL024424
    Expression
    Ubiquitous expression in duodenum adult (RPKM 494.4), mammary gland adult (RPKM 485.2) and 27 other tissues See more
    Orthologs

    Genomic context

    See Pkm in Genome Data Viewer
    Location:
    9 B; 9 32.03 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (59656368..59679375)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (59504415..59527182)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene CUGBP, Elav-like family member 6 Neighboring gene poly (ADP-ribose) polymerase family, member 6 Neighboring gene GRAM domain containing 2 Neighboring gene predicted gene, 39347 Neighboring gene SUMO/sentrin specific peptidase 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    potassium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    pyruvate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    pyruvate kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pyruvate kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    thyroid hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ATP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    animal organ regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to insulin stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glycolytic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    liver development ISO
    Inferred from Sequence Orthology
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    pyruvate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    skeletal muscle tissue regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix HDA PubMed 
    mitochondrion HDA PubMed 
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    photoreceptor inner segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pyruvate kinase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    pyruvate kinase PKM
    Names
    pyruvate kinase 3
    pyruvate kinase isozymes M1/M2
    pyruvate kinase muscle isozyme
    NP_001240812.1
    NP_035229.2
    XP_006510918.1
    XP_006510919.1
    XP_011240975.1
    XP_011240976.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253883.1NP_001240812.1  pyruvate kinase PKM isoform M1

      See identical proteins and their annotated locations for NP_001240812.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform M1. Isoforms M1 and M2 are identical in length but have different sequences.
      Source sequence(s)
      AK135397, AK155655, BB819292, BI985789, CB846337
      Consensus CDS
      CCDS57681.1
      UniProtKB/Swiss-Prot
      P52480
      Related
      ENSMUSP00000128770.2, OTTMUSP00000079743, ENSMUST00000163694.3, OTTMUST00000154187
      Conserved Domains (1) summary
      cd00288
      Location:42530
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    2. NM_011099.3NP_035229.2  pyruvate kinase PKM isoform M2

      See identical proteins and their annotated locations for NP_035229.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon and contains an alternate in-frame exon in the coding region, compared to variant 1. The encoded isoform (M2) is identical in length to isoform M1, but has a different sequence.
      Source sequence(s)
      AK135397, BB819292, CB846337
      Consensus CDS
      CCDS40659.1
      UniProtKB/Swiss-Prot
      P52480
      Related
      ENSMUSP00000034834.9, OTTMUSP00000079735, ENSMUST00000034834.15, OTTMUST00000154175
      Conserved Domains (1) summary
      cd00288
      Location:42530
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      59656368..59679375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510855.1XP_006510918.1  pyruvate kinase PKM isoform X3

      See identical proteins and their annotated locations for XP_006510918.1

      UniProtKB/Swiss-Prot
      P52480
      Conserved Domains (1) summary
      cd00288
      Location:42530
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    2. XM_011242674.1XP_011240976.1  pyruvate kinase PKM isoform X2

      Conserved Domains (2) summary
      cd00288
      Location:105593
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
      TIGR01064
      Location:106590
      pyruv_kin; pyruvate kinase
    3. XM_011242673.1XP_011240975.1  pyruvate kinase PKM isoform X1

      See identical proteins and their annotated locations for XP_011240975.1

      UniProtKB/Swiss-Prot
      P52480
      Conserved Domains (1) summary
      cd00288
      Location:42530
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    4. XM_006510856.2XP_006510919.1  pyruvate kinase PKM isoform X4

      Conserved Domains (2) summary
      cd00288
      Location:68515
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
      TIGR01064
      Location:68512
      pyruv_kin; pyruvate kinase
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