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    Pcna proliferating cell nuclear antigen [ Mus musculus (house mouse) ]

    Gene ID: 18538, updated on 6-Nov-2018

    Summary

    Official Symbol
    Pcnaprovided by MGI
    Official Full Name
    proliferating cell nuclear antigenprovided by MGI
    Primary source
    MGI:MGI:97503
    See related
    Ensembl:ENSMUSG00000027342 Vega:OTTMUSG00000015547
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Broad expression in liver E14.5 (RPKM 270.8), liver E14 (RPKM 268.7) and 26 other tissues See more
    Orthologs

    Genomic context

    See Pcna in Genome Data Viewer
    Location:
    2 F2; 2 64.15 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (132249286..132253180, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (132075022..132078916, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene 14051 Neighboring gene predicted gene, 29720 Neighboring gene transmembrane protein 230 Neighboring gene expressed sequence AV099323 Neighboring gene predicted gene, 46766 Neighboring gene CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA polymerase processivity factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    MutLalpha complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    dinucleotide insertion or deletion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    purine-specific mismatch base pair DNA N-glycosylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    base-excision repair, gap-filling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leading strand elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mismatch repair ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic telomere maintenance via semi-conservative replication IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of deoxyribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    replication fork processing IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to lipid ISO
    Inferred from Sequence Orthology
    more info
     
    translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translesion synthesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    PCNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    PCNA complex ISO
    Inferred from Sequence Orthology
    more info
     
    PCNA-p21 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    centrosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein kinase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear lamina IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear replication fork ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    replication fork IDA
    Inferred from Direct Assay
    more info
    PubMed 
    replication fork ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    proliferating cell nuclear antigen
    Names
    cyclin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011045.2NP_035175.1  proliferating cell nuclear antigen

      See identical proteins and their annotated locations for NP_035175.1

      Status: PROVISIONAL

      Source sequence(s)
      AL807793
      Consensus CDS
      CCDS16771.1
      UniProtKB/Swiss-Prot
      P17918
      UniProtKB/TrEMBL
      Q542J9
      Related
      ENSMUSP00000028817.6, OTTMUSP00000016567, ENSMUST00000028817.6, OTTMUST00000036927
      Conserved Domains (2) summary
      cd00577
      Location:4256
      PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
      TIGR00590
      Location:1259
      pcna; proliferating cell nuclear antigen (pcna)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      132249286..132253180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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