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    Pcna proliferating cell nuclear antigen [ Mus musculus (house mouse) ]

    Gene ID: 18538, updated on 17-Aug-2021

    Summary

    Official Symbol
    Pcnaprovided by MGI
    Official Full Name
    proliferating cell nuclear antigenprovided by MGI
    Primary source
    MGI:MGI:97503
    See related
    Ensembl:ENSMUSG00000027342
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Broad expression in liver E14.5 (RPKM 270.8), liver E14 (RPKM 268.7) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Pcna in Genome Data Viewer
    Location:
    2 F2; 2 64.15 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (132091206..132095100, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (132249286..132253180, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (132075022..132078916, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 14051 Neighboring gene predicted gene, 29720 Neighboring gene transmembrane protein 230 Neighboring gene expressed sequence AV099323 Neighboring gene predicted gene, 46766 Neighboring gene CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA polymerase processivity factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables MutLalpha complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables dinucleotide insertion or deletion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone acetyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables purine-specific mismatch base pair DNA N-glycosylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within base-excision repair, gap-filling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in leading strand elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mismatch repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic telomere maintenance via semi-conservative replication IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-directed DNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of deoxyribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in replication fork processing IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to lipid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in translesion synthesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of PCNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of PCNA complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of PCNA-p21 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cyclin-dependent protein kinase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear lamina IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear replication fork ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in replication fork IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in replication fork ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    proliferating cell nuclear antigen
    Names
    cyclin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011045.2NP_035175.1  proliferating cell nuclear antigen

      See identical proteins and their annotated locations for NP_035175.1

      Status: PROVISIONAL

      Source sequence(s)
      AL807793
      Consensus CDS
      CCDS16771.1
      UniProtKB/Swiss-Prot
      P17918
      UniProtKB/TrEMBL
      Q542J9
      Related
      ENSMUSP00000028817.7, ENSMUST00000028817.7
      Conserved Domains (2) summary
      cd00577
      Location:4256
      PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
      TIGR00590
      Location:1259
      pcna; proliferating cell nuclear antigen (pcna)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      132091206..132095100 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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