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PCNA proliferating cell nuclear antigen [ Homo sapiens (human) ]

Gene ID: 5111, updated on 25-Nov-2021

Summary

Official Symbol
PCNAprovided by HGNC
Official Full Name
proliferating cell nuclear antigenprovided by HGNC
Primary source
HGNC:HGNC:8729
See related
Ensembl:ENSG00000132646 MIM:176740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATLD2
Summary
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 118.4), lymph node (RPKM 72.7) and 24 other tissues See more
Orthologs
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Genomic context

See PCNA in Genome Data Viewer
Location:
20p12.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (5114953..5126622, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (5095599..5107268, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S21 pseudogene 7 Neighboring gene transmembrane protein 230 Neighboring gene RNA, 5S ribosomal pseudogene 474 Neighboring gene PCNA antisense RNA 1 Neighboring gene CDP-diacylglycerol synthase 2 Neighboring gene Sharpr-MPRA regulatory region 2649 Neighboring gene meiotic recombination hotspot R

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of proliferating cell nuclear antigen (PCNA) in Jurkat cells PubMed
tat When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8367

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA polymerase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables DNA polymerase processivity factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MutLalpha complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables damaged DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables dinucleotide insertion or deletion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables estrogen receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables histone acetyltransferase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein C-terminus binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables purine-specific mismatch base pair DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in base-excision repair, gap-filling IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to UV IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in estrous cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in leading strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in liver regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mismatch repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitotic telomere maintenance via semi-conservative replication ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-directed DNA polymerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of deoxyribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in replication fork processing ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in response to L-glutamate IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cadmium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in response to dexamethasone IEA
Inferred from Electronic Annotation
more info
 
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
 
involved_in translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in translesion synthesis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of PCNA complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of PCNA complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of PCNA complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of PCNA-p21 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, telomeric region HDA PubMed 
part_of cyclin-dependent protein kinase holoenzyme complex IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nuclear lamina IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear replication fork IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in replication fork IDA
Inferred from Direct Assay
more info
PubMed 
part_of replisome TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
proliferating cell nuclear antigen
Names
DNA polymerase delta auxiliary protein
cyclin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047066.1 RefSeqGene

    Range
    5001..16670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002592.2NP_002583.1  proliferating cell nuclear antigen

    See identical proteins and their annotated locations for NP_002583.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC000491, BU626265, CB990423
    Consensus CDS
    CCDS13087.1
    UniProtKB/Swiss-Prot
    P12004
    Related
    ENSP00000368458.3, ENST00000379160.3
    Conserved Domains (1) summary
    TIGR00590
    Location:1259
    pcna; proliferating cell nuclear antigen (pcna)
  2. NM_182649.2NP_872590.1  proliferating cell nuclear antigen

    See identical proteins and their annotated locations for NP_872590.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK313286, BC000491, BU626265
    Consensus CDS
    CCDS13087.1
    UniProtKB/Swiss-Prot
    P12004
    Related
    ENSP00000368438.5, ENST00000379143.10
    Conserved Domains (1) summary
    TIGR00590
    Location:1259
    pcna; proliferating cell nuclear antigen (pcna)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    5114953..5126622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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