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PCNA proliferating cell nuclear antigen [ Homo sapiens (human) ]

Gene ID: 5111, updated on 24-Nov-2020

Summary

Official Symbol
PCNAprovided by HGNC
Official Full Name
proliferating cell nuclear antigenprovided by HGNC
Primary source
HGNC:HGNC:8729
See related
Ensembl:ENSG00000132646 MIM:176740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATLD2
Summary
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 118.4), lymph node (RPKM 72.7) and 24 other tissues See more
Orthologs

Genomic context

See PCNA in Genome Data Viewer
Location:
20p12.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (5114953..5126622, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (5095599..5107268, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S21 pseudogene 7 Neighboring gene transmembrane protein 230 Neighboring gene RNA, 5S ribosomal pseudogene 474 Neighboring gene PCNA antisense RNA 1 Neighboring gene CDP-diacylglycerol synthase 2 Neighboring gene meiotic recombination hotspot R

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of proliferating cell nuclear antigen (PCNA) in Jurkat cells PubMed
tat When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8367

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA polymerase binding IPI
Inferred from Physical Interaction
more info
PubMed 
DNA polymerase processivity factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MutLalpha complex binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
damaged DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
dinucleotide insertion or deletion binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
estrogen receptor binding IEA
Inferred from Electronic Annotation
more info
 
histone acetyltransferase binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
purine-specific mismatch base pair DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, detection of DNA damage TAS
Traceable Author Statement
more info
 
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
Traceable Author Statement
more info
 
base-excision repair, gap-filling IEA
Inferred from Electronic Annotation
more info
 
cellular response to UV IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
cellular response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
epithelial cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
error-free translesion synthesis TAS
Traceable Author Statement
more info
 
error-prone translesion synthesis TAS
Traceable Author Statement
more info
 
estrous cycle IEA
Inferred from Electronic Annotation
more info
 
heart development IEA
Inferred from Electronic Annotation
more info
 
leading strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
liver regeneration IEA
Inferred from Electronic Annotation
more info
 
mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatch repair IDA
Inferred from Direct Assay
more info
PubMed 
mismatch repair TAS
Traceable Author Statement
more info
 
mitotic telomere maintenance via semi-conservative replication ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
nucleotide-excision repair, DNA gap filling TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, DNA incision TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, DNA incision, 5'-to lesion TAS
Traceable Author Statement
more info
 
positive regulation of DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA-directed DNA polymerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of deoxyribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination TAS
Traceable Author Statement
more info
 
regulation of transcription involved in G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
replication fork processing ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
response to L-glutamate IEA
Inferred from Electronic Annotation
more info
 
response to cadmium ion IEA
Inferred from Electronic Annotation
more info
 
response to dexamethasone IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
telomere maintenance TAS
Traceable Author Statement
more info
 
telomere maintenance via semi-conservative replication TAS
Traceable Author Statement
more info
 
transcription-coupled nucleotide-excision repair TAS
Traceable Author Statement
more info
 
translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translesion synthesis IDA
Inferred from Direct Assay
more info
PubMed 
translesion synthesis TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PCNA complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
PCNA complex IDA
Inferred from Direct Assay
more info
PubMed 
PCNA-p21 complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
chromosome, telomeric region HDA PubMed 
cyclin-dependent protein kinase holoenzyme complex IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nuclear lamina IEA
Inferred from Electronic Annotation
more info
 
nuclear replication fork IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
replication fork IDA
Inferred from Direct Assay
more info
PubMed 
replisome TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
proliferating cell nuclear antigen
Names
DNA polymerase delta auxiliary protein
cyclin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047066.1 RefSeqGene

    Range
    5001..16670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002592.2NP_002583.1  proliferating cell nuclear antigen

    See identical proteins and their annotated locations for NP_002583.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC000491, BU626265, CB990423
    Consensus CDS
    CCDS13087.1
    UniProtKB/Swiss-Prot
    P12004
    Related
    ENSP00000368458.3, ENST00000379160.3
    Conserved Domains (1) summary
    TIGR00590
    Location:1259
    pcna; proliferating cell nuclear antigen (pcna)
  2. NM_182649.2NP_872590.1  proliferating cell nuclear antigen

    See identical proteins and their annotated locations for NP_872590.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK313286, BC000491, BU626265
    Consensus CDS
    CCDS13087.1
    UniProtKB/Swiss-Prot
    P12004
    Related
    ENSP00000368438.5, ENST00000379143.10
    Conserved Domains (1) summary
    TIGR00590
    Location:1259
    pcna; proliferating cell nuclear antigen (pcna)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    5114953..5126622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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