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    F10D7.5 E3 ubiquitin-protein ligase NEURL1B;NHR domain-containing protein;Neuralized-like protein 2 [ Caenorhabditis elegans ]

    Gene ID: 181767, updated on 23-Nov-2023

    Summary

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    Gene symbol
    F10D7.5
    Gene description
    E3 ubiquitin-protein ligase NEURL1B;NHR domain-containing protein;Neuralized-like protein 2
    Primary source
    WormBase:WBGene00017342
    Locus tag
    CELE_F10D7.5
    See related
    AllianceGenome:WB:WBGene00017342
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Orthologous to several human genes including NEURL1 (neuralized E3 ubiquitin protein ligase 1) and NEURL1B (neuralized E3 ubiquitin protein ligase 1B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: X
    Exon count:
    15
    Sequence:
    Chromosome: X; NC_003284.9 (17383125..17391615, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene CB1 cannabinoid receptor-interacting protein 1 Neighboring gene Galectin;ZP domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SCP domain-containing protein Neighboring gene ShKT domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1. Wang W, et al. Traffic, 2008 May. PMID 18298590, Free PMC Article
    2. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase NEURL1B;NHR domain-containing protein;Neuralized-like protein 2
    NP_001379824.1
    • Partially confirmed by transcript evidence
    NP_510817.3
    • Confirmed by transcript evidence
    NP_510818.3
    • Confirmed by transcript evidence
    NP_510819.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      17383125..17391615 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078417.6 → NP_510818.3  Neuralized-like protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510818.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JP67
      Conserved Domains (2) summary
      smart00588
      Location:37 → 158
      NEUZ; domain in neuralized proteins
      cd16647
      Location:565 → 605
      mRING-HC-C3HC5_NEU1; Modified RING finger, HC subclass (C3HC5-type), found in neuralized-like protein NEURL1A, NEURL1B, and similar proteins

    2. NM_078418.4 → NP_510819.3  E3 ubiquitin-protein ligase NEURL1B [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510819.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JP66
      Conserved Domains (2) summary
      smart00588
      Location:68 → 190
      NEUZ; domain in neuralized proteins
      cd16647
      Location:385 → 425
      mRING-HC-C3HC5_NEU1; Modified RING finger, HC subclass (C3HC5-type), found in neuralized-like protein NEURL1A, NEURL1B, and similar proteins

    3. NM_078416.5 → NP_510817.3  NHR domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510817.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JP65
      Conserved Domains (1) summary
      smart00588
      Location:37 → 158
      NEUZ; domain in neuralized proteins

    4. NM_001392919.1 → NP_001379824.1  NHR domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQ80
      Conserved Domains (1) summary
      smart00588
      Location:37 → 158
      NEUZ; domain in neuralized proteins
    Nucleotide Protein
    Heading Accession and Version

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