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    sta-1 Signal transducer and activator of transcription 1 [ Caenorhabditis elegans ]

    Gene ID: 178465, updated on 18-Sep-2024

    Summary

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    Official Symbol
    sta-1
    Official Full Name
    Signal transducer and activator of transcription 1
    Primary source
    WormBase:WBGene00013111
    Locus tag
    CELE_Y51H4A.17
    See related
    AllianceGenome:WB:WBGene00013111
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables sequence-specific DNA binding activity. Involved in dauer larval development and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including anal depressor muscle; body wall musculature; coelomocyte; intestine; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); breast cancer (multiple); carcinoma (multiple); reproductive organ cancer (multiple); and systemic scleroderma (multiple). Orthologous to several human genes including STAT5A (signal transducer and activator of transcription 5A) and STAT5B (signal transducer and activator of transcription 5B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (16664320..16671472)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Gly Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. sta-1 is repressed by mir-58 family in Caenorhabditis elegans. Lozano E, et al. Worm, 2016. PMID 28090395, Free PMC Article
    2. C. elegans STAT: evolution of a regulatory switch. Wang Y, et al. FASEB J, 2006 Aug. PMID 16873887
    3. An Alternative STAT Signaling Pathway Acts in Viral Immunity in Caenorhabditis elegans. Tanguy M, et al. mBio, 2017 Sep 5. PMID 28874466, Free PMC Article
    4. Dissection of lin-11 enhancer regions in Caenorhabditis elegans and other nematodes. Marri S, et al. Dev Biol, 2009 Jan 15. PMID 18950616
    5. Surveillance Immunity: An Emerging Paradigm of Innate Defense Activation in Caenorhabditis elegans. Pukkila-Worley R. PLoS Pathog, 2016 Sep. PMID 27631629, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings show the STAT homolog STA-1 orchestrates antiviral immunity
      Title: An Alternative STAT Signaling Pathway Acts in Viral Immunity in Caenorhabditis elegans.
    2. DNA binding is not a necessary prerequisite for nuclear retention of activated STAT proteins
      Title: C. elegans STAT: evolution of a regulatory switch.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Signal transducer and activator of transcription 1
    NP_001122814.1
    • Confirmed by transcript evidence
    NP_001122815.1
    • Confirmed by transcript evidence
    NP_502974.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      16664320..16671472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070573.6 → NP_502974.2  Signal transducer and activator of transcription 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502974.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A5HWB4, Q29TW4, Q9NAD6
      Conserved Domains (3) summary
      cd09919
      Location:457 → 574
      SH2_STAT_family; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) family
      pfam01017
      Location:7 → 196
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:199 → 466
      STAT_bind; STAT protein, DNA binding domain

    2. NM_001129343.3 → NP_001122815.1  Signal transducer and activator of transcription 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122815.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NAD6
      Conserved Domains (3) summary
      cd09919
      Location:457 → 574
      SH2_STAT_family; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) family
      pfam01017
      Location:7 → 196
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:199 → 466
      STAT_bind; STAT protein, DNA binding domain

    3. NM_001129342.4 → NP_001122814.1  Signal transducer and activator of transcription 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122814.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NAD6
      Conserved Domains (3) summary
      cd09919
      Location:457 → 553
      SH2_STAT_family; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) family
      pfam01017
      Location:7 → 196
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:199 → 466
      STAT_bind; STAT protein, DNA binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NAD6.2

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