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    Mtf2 metal response element binding transcription factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 17765, updated on 26-Sep-2022

    Summary

    Official Symbol
    Mtf2provided by MGI
    Official Full Name
    metal response element binding transcription factor 2provided by MGI
    Primary source
    MGI:MGI:105050
    See related
    Ensembl:ENSMUSG00000029267 AllianceGenome:MGI:105050
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    M96; Pcl2; 9230112N11Rik
    Summary
    Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and methylated histone binding activity. Involved in several processes, including regulation of histone H3-K27 methylation; regulation of transcription by RNA polymerase II; and segment specification. Acts upstream of or within cellular response to leukemia inhibitory factor. Part of ESC/E(Z) complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human MTF2 (metal response element binding transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 8.1), CNS E14 (RPKM 6.6) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mtf2 in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108213518..108257085)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108065660..108109219)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42150 Neighboring gene ribosomal protein S19, pseudogene 8 Neighboring gene transmembrane p24 trafficking protein 5 Neighboring gene coiled-coil domain containing 18 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC116639

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of ESC/E(Z) complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    metal-response element-binding transcription factor 2
    Names
    mPCl2
    metal regulatory transcription factor 2
    metal response element DNA-binding protein M96
    polycomb-like protein 2
    ziRF1
    zinc-regulated factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253877.1NP_001240806.1  metal-response element-binding transcription factor 2 isoform 2

      See identical proteins and their annotated locations for NP_001240806.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction in the 5' end compared to variant 7, which results in the use of a downstream AUG start codon. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2-6 all encode the same isoform (2).
      Source sequence(s)
      AK031409, AK032819, BC092237, CJ311871
      UniProtKB/Swiss-Prot
      Q02395
      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442489
      Mtf2_C; Polycomb-like MTF2 factor 2
    2. NM_001253878.1NP_001240807.1  metal-response element-binding transcription factor 2 isoform 2

      See identical proteins and their annotated locations for NP_001240807.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 7, which results in the use of a downstream AUG start codon. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2-6 all encode the same isoform (2).
      Source sequence(s)
      AK139685, BC092237, CJ311871
      UniProtKB/Swiss-Prot
      Q02395
      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442489
      Mtf2_C; Polycomb-like MTF2 factor 2
    3. NM_001253879.1NP_001240808.1  metal-response element-binding transcription factor 2 isoform 2

      See identical proteins and their annotated locations for NP_001240808.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 7, which results in the use of a downstream AUG start codon. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2-6 all encode the same isoform (2).
      Source sequence(s)
      AK030752, AK031409, BC092237, CJ311871
      UniProtKB/Swiss-Prot
      Q02395
      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442489
      Mtf2_C; Polycomb-like MTF2 factor 2
    4. NM_001253880.1NP_001240809.1  metal-response element-binding transcription factor 2 isoform 2

      See identical proteins and their annotated locations for NP_001240809.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 7, which results in the use of a downstream AUG start codon. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2-6 all encode the same isoform (2).
      Source sequence(s)
      AK031409, AK137539, BC092237, BC100340, CJ311871
      UniProtKB/Swiss-Prot
      Q02395
      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442489
      Mtf2_C; Polycomb-like MTF2 factor 2
    5. NM_001359088.1NP_001346017.1  metal-response element-binding transcription factor 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) encodes the longest isoform (3).
      Source sequence(s)
      AC134402
      Conserved Domains (4) summary
      cd15578
      Location:115167
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:214265
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:555602
      Mtf2_C; Polycomb-like MTF2 factor 2
      cd20450
      Location:56109
      Tudor_MTF2; Tudor domain found in metal-response element-binding transcription factor 2 (MTF2) and similar proteins
    6. NM_001359089.1NP_001346018.1  metal-response element-binding transcription factor 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 7, which results in the use of a downstream AUG start codon. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2-6 all encode the same isoform (2).
      Source sequence(s)
      AC134402
      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442489
      Mtf2_C; Polycomb-like MTF2 factor 2
    7. NM_013827.3NP_038855.2  metal-response element-binding transcription factor 2 isoform 1

      See identical proteins and their annotated locations for NP_038855.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate exon in the 5' end compared to variant 7. The resulting isoform (1) has a shorter and distinct N-terminus compared to isoform 3.
      Source sequence(s)
      AK031409, AK137539, BC092237, CJ311871
      Consensus CDS
      CCDS39201.1
      UniProtKB/Swiss-Prot
      Q02395, Q8BSJ7
      Related
      ENSMUSP00000080278.5, ENSMUST00000081567.11
      Conserved Domains (4) summary
      smart00333
      Location:4595
      TUDOR; Tudor domain
      cd15578
      Location:104156
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:203254
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:544590
      Mtf2_C; Polycomb-like MTF2 factor 2

    RNA

    1. NR_152817.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' end and uses an alternate splice junction in the 3' end compared to variant 7. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC134402, AK137539

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      108213518..108257085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164857.1XP_036020750.1  metal-response element-binding transcription factor 2 isoform X2

      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442489
      Mtf2_C; Polycomb-like MTF2 factor 2
    2. XM_036164854.1XP_036020747.1  metal-response element-binding transcription factor 2 isoform X2

      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442489
      Mtf2_C; Polycomb-like MTF2 factor 2
    3. XM_036164865.1XP_036020758.1  metal-response element-binding transcription factor 2 isoform X2

      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442489
      Mtf2_C; Polycomb-like MTF2 factor 2
    4. XM_036164861.1XP_036020754.1  metal-response element-binding transcription factor 2 isoform X2

      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442489
      Mtf2_C; Polycomb-like MTF2 factor 2
    5. XM_011249412.4XP_011247714.1  metal-response element-binding transcription factor 2 isoform X1

      See identical proteins and their annotated locations for XP_011247714.1

      Conserved Domains (4) summary
      cd15578
      Location:115167
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:214265
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:555602
      Mtf2_C; Polycomb-like MTF2 factor 2
      cd20450
      Location:56109
      Tudor_MTF2; Tudor domain found in metal-response element-binding transcription factor 2 (MTF2) and similar proteins
    6. XM_036164859.1XP_036020752.1  metal-response element-binding transcription factor 2 isoform X2

      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442489
      Mtf2_C; Polycomb-like MTF2 factor 2
    7. XM_036164853.1XP_036020746.1  metal-response element-binding transcription factor 2 isoform X1

      Conserved Domains (4) summary
      cd15578
      Location:115167
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:214265
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:555602
      Mtf2_C; Polycomb-like MTF2 factor 2
      cd20450
      Location:56109
      Tudor_MTF2; Tudor domain found in metal-response element-binding transcription factor 2 (MTF2) and similar proteins
    8. XM_011249417.4XP_011247719.1  metal-response element-binding transcription factor 2 isoform X3

      Conserved Domains (3) summary
      cd15578
      Location:115167
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam18104
      Location:6095
      Tudor_2; Jumonji domain-containing protein 2A Tudor domain
      cl22851
      Location:214265
      PHD_SF; PHD finger superfamily
    9. XM_036164860.1XP_036020753.1  metal-response element-binding transcription factor 2 isoform X2

      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442489
      Mtf2_C; Polycomb-like MTF2 factor 2
    10. XM_030254193.2XP_030110053.1  metal-response element-binding transcription factor 2 isoform X2

      Related
      ENSMUST00000131264.8
      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442489
      Mtf2_C; Polycomb-like MTF2 factor 2
    11. XM_030254194.2XP_030110054.1  metal-response element-binding transcription factor 2 isoform X2

      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442489
      Mtf2_C; Polycomb-like MTF2 factor 2
    12. XM_036164863.1XP_036020756.1  metal-response element-binding transcription factor 2 isoform X2

      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442489
      Mtf2_C; Polycomb-like MTF2 factor 2
    13. XM_036164862.1XP_036020755.1  metal-response element-binding transcription factor 2 isoform X2

      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442489
      Mtf2_C; Polycomb-like MTF2 factor 2
    14. XM_030254189.2XP_030110049.1  metal-response element-binding transcription factor 2 isoform X1

      Conserved Domains (4) summary
      cd15578
      Location:115167
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:214265
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:555602
      Mtf2_C; Polycomb-like MTF2 factor 2
      cd20450
      Location:56109
      Tudor_MTF2; Tudor domain found in metal-response element-binding transcription factor 2 (MTF2) and similar proteins
    15. XM_036164858.1XP_036020751.1  metal-response element-binding transcription factor 2 isoform X2

      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442489
      Mtf2_C; Polycomb-like MTF2 factor 2
    16. XM_036164855.1XP_036020748.1  metal-response element-binding transcription factor 2 isoform X2

      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442489
      Mtf2_C; Polycomb-like MTF2 factor 2
    17. XM_011249416.4XP_011247718.1  metal-response element-binding transcription factor 2 isoform X2

      See identical proteins and their annotated locations for XP_011247718.1

      UniProtKB/Swiss-Prot
      Q02395
      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442489
      Mtf2_C; Polycomb-like MTF2 factor 2
    18. XM_036164866.1XP_036020759.1  metal-response element-binding transcription factor 2 isoform X2

      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442489
      Mtf2_C; Polycomb-like MTF2 factor 2

    RNA

    1. XR_389261.5 RNA Sequence

    2. XR_004942441.1 RNA Sequence