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MTF2 metal response element binding transcription factor 2 [ Homo sapiens (human) ]

Gene ID: 22823, updated on 10-Oct-2020

Summary

Official Symbol
MTF2provided by HGNC
Official Full Name
metal response element binding transcription factor 2provided by HGNC
Primary source
HGNC:HGNC:29535
See related
Ensembl:ENSG00000143033 MIM:609882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
M96; PCL2; TDRD19A; dJ976O13.2
Expression
Ubiquitous expression in testis (RPKM 5.1), lymph node (RPKM 4.5) and 25 other tissues See more
Orthologs

Genomic context

See MTF2 in Genome Data Viewer
Location:
1p22.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (93079283..93139076)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (93544792..93604638)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 210, pseudogene Neighboring gene RN7SK pseudogene 123 Neighboring gene Sharpr-MPRA regulatory region 13810 Neighboring gene transmembrane p24 trafficking protein 5 Neighboring gene coiled-coil domain containing 18 Neighboring gene ribosomal protein L36a pseudogene 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
chromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of gene expression, epigenetic TAS
Traceable Author Statement
more info
 
negative regulation of histone H3-K27 methylation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of histone H3-K27 methylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
segment specification ISS
Inferred from Sequence or Structural Similarity
more info
 
stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
colocalizes_with ESC/E(Z) complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with ESC/E(Z) complex ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
metal-response element-binding transcription factor 2
Names
hPCl2
metal regulatory transcription factor 2
metal-response element DNA-binding protein M96
polycomb-like 2
polycomb-like protein 2
putative DNA binding protein
tudor domain containing 19A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164391.2NP_001157863.1  metal-response element-binding transcription factor 2 isoform c

    See identical proteins and their annotated locations for NP_001157863.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate portion of a coding exon compared to variant 1, that causes a frameshift. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AF072814, AK302776, AL117354, BQ025793, DB173315
    Consensus CDS
    CCDS53341.1
    UniProtKB/Swiss-Prot
    Q9Y483
    UniProtKB/TrEMBL
    B4DZ69, B4DZG1
    Related
    ENSP00000444962.1, ENST00000545708.5
    Conserved Domains (3) summary
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442489
    Mtf2_C; Polycomb-like MTF2 factor 2
  2. NM_001164392.2NP_001157864.1  metal-response element-binding transcription factor 2 isoform b

    See identical proteins and their annotated locations for NP_001157864.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AL117354, BC010013, BQ025793, DB173315
    Consensus CDS
    CCDS53340.1
    UniProtKB/TrEMBL
    Q96G26
    Related
    ENSP00000359326.4, ENST00000370303.4
    Conserved Domains (4) summary
    smart00333
    Location:4595
    TUDOR; Tudor domain
    cd15578
    Location:104156
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:203254
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:487533
    Mtf2_C; Polycomb-like MTF2 factor 2
  3. NM_001164393.2NP_001157865.1  metal-response element-binding transcription factor 2 isoform c

    See identical proteins and their annotated locations for NP_001157865.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two coding exons compared to variant 1, that causes a frameshift. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AK302900, AL117354, BQ025793
    Consensus CDS
    CCDS53341.1
    UniProtKB/Swiss-Prot
    Q9Y483
    UniProtKB/TrEMBL
    B4DZG1
    Related
    ENSP00000443295.1, ENST00000540243.5
    Conserved Domains (3) summary
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442489
    Mtf2_C; Polycomb-like MTF2 factor 2
  4. NM_007358.4NP_031384.1  metal-response element-binding transcription factor 2 isoform a

    See identical proteins and their annotated locations for NP_031384.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AF086908, AJ010014, AL117354, BC001897, BQ025793, CA417978, DB173315
    Consensus CDS
    CCDS742.1
    UniProtKB/Swiss-Prot
    Q9Y483
    UniProtKB/TrEMBL
    Q7Z534
    Related
    ENSP00000359321.4, ENST00000370298.9
    Conserved Domains (4) summary
    cd15578
    Location:104156
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:203254
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:544591
    Mtf2_C; Polycomb-like MTF2 factor 2
    pfam18104
    Location:4984
    Tudor_2; Jumonji domain-containing protein 2A Tudor domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    93079283..93139076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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