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    TENT2 terminal nucleotidyltransferase 2 [ Homo sapiens (human) ]

    Gene ID: 167153, updated on 17-Jun-2024

    Summary

    Official Symbol
    TENT2provided by HGNC
    Official Full Name
    terminal nucleotidyltransferase 2provided by HGNC
    Primary source
    HGNC:HGNC:26776
    See related
    Ensembl:ENSG00000164329 MIM:614121; AllianceGenome:HGNC:26776
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APD4; GLD2; TUT2; PAPD4
    Summary
    Enables 5'-3' RNA polymerase activity and polynucleotide adenylyltransferase activity. Involved in RNA metabolic process and negative regulation of RNA catabolic process. Predicted to be located in nucleus. Predicted to be part of nuclear RNA-directed RNA polymerase complex. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bone marrow (RPKM 14.6), lymph node (RPKM 12.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TENT2 in Genome Data Viewer
    Location:
    5q14.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (79612441..79688246)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (80096704..80172520)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (78908264..78984069)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901013 Neighboring gene uncharacterized LOC105379047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22726 Neighboring gene uncharacterized LOC124901014 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:78907869-78909068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:78925303-78925804 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:78925805-78926304 Neighboring gene NANOG hESC enhancer GRCh37_chr5:78968175-78968748 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:78985169-78985670 Neighboring gene cardiomyopathy associated 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:79065865-79066605 Neighboring gene OCT4 hESC enhancer GRCh37_chr5:79067050-79067551 Neighboring gene uncharacterized LOC102724557

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog
    Novel locus FER is associated with serum HMW adiponectin levels.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ38499

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables poly(A) RNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of nuclear RNA-directed RNA polymerase complex IC
    Inferred by Curator
    more info
    PubMed 

    General protein information

    Preferred Names
    poly(A) RNA polymerase GLD2
    Names
    PAP associated domain containing 4
    PAP-associated domain-containing protein 4
    TUTase 2
    poly(A) RNA polymerase D4, non-canonical
    terminal uridylyltransferase 2
    NP_001107865.1
    NP_001107866.1
    NP_001284673.1
    NP_001284674.1
    NP_001336477.1
    NP_001336478.1
    NP_001336479.1
    NP_001336480.1
    NP_001336481.1
    NP_001336482.1
    NP_001336483.1
    NP_001375022.1
    NP_001375023.1
    NP_001375024.1
    NP_001375025.1
    NP_001375026.1
    NP_001375027.1
    NP_001375028.1
    NP_001375029.1
    NP_001375030.1
    NP_001375031.1
    NP_001375032.1
    NP_001375034.1
    NP_001375035.1
    NP_001375036.1
    NP_001375037.1
    NP_001375038.1
    NP_001375039.1
    NP_001375040.1
    NP_001375041.1
    NP_001375042.1
    NP_001375043.1
    NP_001375044.1
    NP_001375045.1
    NP_001375046.1
    NP_001375047.1
    NP_001375048.1
    NP_001375049.1
    NP_001375050.1
    NP_001375051.1
    NP_001375052.1
    NP_001375053.1
    NP_001375054.1
    NP_001375055.1
    NP_001375056.1
    NP_001375057.1
    NP_001375058.1
    NP_001375059.1
    NP_001375060.1
    NP_001375061.1
    NP_001375062.1
    NP_001375063.1
    NP_001375064.1
    NP_001375065.1
    NP_001375066.1
    NP_776158.2
    XP_011541522.1
    XP_011541523.1
    XP_011541526.1
    XP_011541527.1
    XP_011541531.1
    XP_016864641.1
    XP_047272800.1
    XP_047272801.1
    XP_047272802.1
    XP_047272803.1
    XP_047272804.1
    XP_047272805.1
    XP_047272806.1
    XP_047272807.1
    XP_047272808.1
    XP_047272809.1
    XP_047272810.1
    XP_047272811.1
    XP_047272812.1
    XP_047272813.1
    XP_047272814.1
    XP_047272815.1
    XP_047272816.1
    XP_047272817.1
    XP_047272818.1
    XP_047272820.1
    XP_054207855.1
    XP_054207856.1
    XP_054207857.1
    XP_054207858.1
    XP_054207859.1
    XP_054207860.1
    XP_054207861.1
    XP_054207862.1
    XP_054207863.1
    XP_054207864.1
    XP_054207865.1
    XP_054207866.1
    XP_054207867.1
    XP_054207868.1
    XP_054207869.1
    XP_054207870.1
    XP_054207871.1
    XP_054207872.1
    XP_054207873.1
    XP_054207874.1
    XP_054207875.1
    XP_054207876.1
    XP_054207877.1
    XP_054207878.1
    XP_054207879.1
    XP_054207880.1
    XP_054207881.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114393.3NP_001107865.1  poly(A) RNA polymerase GLD2 isoform 1

      See identical proteins and their annotated locations for NP_001107865.1

      Status: VALIDATED

      Source sequence(s)
      AC008482, AK095818, AW302247, BC047581, DA803910, DB302918
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    2. NM_001114394.3NP_001107866.1  poly(A) RNA polymerase GLD2 isoform 1

      See identical proteins and their annotated locations for NP_001107866.1

      Status: VALIDATED

      Source sequence(s)
      AC008482, AK095818, AL833136, AW302247, BC047581, DA803910, DB302918
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Related
      ENSP00000397563.1, ENST00000453514.6
      Conserved Domains (1) summary
      COG5260
      Location:154468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    3. NM_001297744.3NP_001284673.1  poly(A) RNA polymerase GLD2 isoform 2

      See identical proteins and their annotated locations for NP_001284673.1

      Status: VALIDATED

      Source sequence(s)
      AC008482, AW302247, BC047581, DB302918
      Consensus CDS
      CCDS75266.1
      UniProtKB/Swiss-Prot
      Q6PIY7
      Related
      ENSP00000393412.2, ENST00000423041.6
      Conserved Domains (1) summary
      COG5260
      Location:154464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    4. NM_001297745.3NP_001284674.1  poly(A) RNA polymerase GLD2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC008482, AL833136, AW302247, BC047581, DB302918
      Consensus CDS
      CCDS75265.1
      UniProtKB/TrEMBL
      D6RAF2
      Related
      ENSP00000421966.1, ENST00000504233.5
      Conserved Domains (2) summary
      cd05402
      Location:176298
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      COG5260
      Location:154425
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    5. NM_001349548.2NP_001336477.1  poly(A) RNA polymerase GLD2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC008482, AK095818, AW302247, BC047581, CN348312, DA803910, DB302918
      Conserved Domains (1) summary
      cl27230
      Location:4245
      PAP_assoc; Cid1 family poly A polymerase
    6. NM_001349549.2NP_001336478.1  poly(A) RNA polymerase GLD2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC008482, AK095818, AL833136, AW302247, BC047581, DA803910, DB302918
      Conserved Domains (1) summary
      COG5260
      Location:154493
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    7. NM_001349550.2NP_001336479.1  poly(A) RNA polymerase GLD2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC008482, AK095818, AW302247, BC047581, CF137152, CN348312, DA803910, DB302918
      Conserved Domains (1) summary
      COG5260
      Location:154493
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    8. NM_001349551.2NP_001336480.1  poly(A) RNA polymerase GLD2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC008482, AK095818, AL833136, AW302247, BC047581, DA803910, DB302918
      Conserved Domains (1) summary
      COG5260
      Location:154489
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    9. NM_001349552.2NP_001336481.1  poly(A) RNA polymerase GLD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008482, AK095818, AL833136, AW302247, BC047581, CF137152, CN348312, DA803910, DB302918
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    10. NM_001349553.2NP_001336482.1  poly(A) RNA polymerase GLD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008482, AK095818, AL833136, AW302247, BC047581, CF137152, CN348312, DA803910, DB302918
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    11. NM_001349554.2NP_001336483.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482, AK095818, AL833136, AW302247, BC047581, CF137152, CN348312, DA803910, DB302918
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    12. NM_001388093.1NP_001375022.1  poly(A) RNA polymerase GLD2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:154493
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    13. NM_001388094.1NP_001375023.1  poly(A) RNA polymerase GLD2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:154493
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    14. NM_001388095.1NP_001375024.1  poly(A) RNA polymerase GLD2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:154489
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    15. NM_001388096.1NP_001375025.1  poly(A) RNA polymerase GLD2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:154489
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    16. NM_001388097.1NP_001375026.1  poly(A) RNA polymerase GLD2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:154489
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    17. NM_001388098.1NP_001375027.1  poly(A) RNA polymerase GLD2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:153488
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    18. NM_001388099.1NP_001375028.1  poly(A) RNA polymerase GLD2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:154478
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    19. NM_001388100.1NP_001375029.1  poly(A) RNA polymerase GLD2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:154478
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    20. NM_001388101.1NP_001375030.1  poly(A) RNA polymerase GLD2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:154474
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    21. NM_001388102.1NP_001375031.1  poly(A) RNA polymerase GLD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    22. NM_001388103.1NP_001375032.1  poly(A) RNA polymerase GLD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    23. NM_001388105.1NP_001375034.1  poly(A) RNA polymerase GLD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    24. NM_001388106.1NP_001375035.1  poly(A) RNA polymerase GLD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    25. NM_001388107.1NP_001375036.1  poly(A) RNA polymerase GLD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    26. NM_001388108.1NP_001375037.1  poly(A) RNA polymerase GLD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    27. NM_001388109.1NP_001375038.1  poly(A) RNA polymerase GLD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    28. NM_001388110.1NP_001375039.1  poly(A) RNA polymerase GLD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    29. NM_001388111.1NP_001375040.1  poly(A) RNA polymerase GLD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    30. NM_001388112.1NP_001375041.1  poly(A) RNA polymerase GLD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    31. NM_001388113.1NP_001375042.1  poly(A) RNA polymerase GLD2 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:153467
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    32. NM_001388114.1NP_001375043.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    33. NM_001388115.1NP_001375044.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    34. NM_001388116.1NP_001375045.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    35. NM_001388117.1NP_001375046.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    36. NM_001388118.1NP_001375047.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    37. NM_001388119.1NP_001375048.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    38. NM_001388120.1NP_001375049.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    39. NM_001388121.1NP_001375050.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    40. NM_001388122.1NP_001375051.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    41. NM_001388123.1NP_001375052.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    42. NM_001388124.1NP_001375053.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    43. NM_001388125.1NP_001375054.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    44. NM_001388126.1NP_001375055.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    45. NM_001388127.1NP_001375056.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    46. NM_001388128.1NP_001375057.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    47. NM_001388129.1NP_001375058.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    48. NM_001388130.1NP_001375059.1  poly(A) RNA polymerase GLD2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:153463
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    49. NM_001388131.1NP_001375060.1  poly(A) RNA polymerase GLD2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:124438
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    50. NM_001388132.1NP_001375061.1  poly(A) RNA polymerase GLD2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:124434
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    51. NM_001388133.1NP_001375062.1  poly(A) RNA polymerase GLD2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75265.1
      UniProtKB/TrEMBL
      D6RAF2
      Conserved Domains (2) summary
      cd05402
      Location:176298
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      COG5260
      Location:154425
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    52. NM_001388134.1NP_001375063.1  poly(A) RNA polymerase GLD2 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (2) summary
      cd05402
      Location:176294
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      COG5260
      Location:154421
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    53. NM_001388135.1NP_001375064.1  poly(A) RNA polymerase GLD2 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (2) summary
      cd05402
      Location:176294
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      COG5260
      Location:154421
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    54. NM_001388136.1NP_001375065.1  poly(A) RNA polymerase GLD2 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:38348
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    55. NM_001388137.1NP_001375066.1  poly(A) RNA polymerase GLD2 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (2) summary
      COG5260
      Location:81270
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
      cl11966
      Location:36100
      NT_Pol-beta-like; Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
    56. NM_173797.5NP_776158.2  poly(A) RNA polymerase GLD2 isoform 1

      See identical proteins and their annotated locations for NP_776158.2

      Status: VALIDATED

      Source sequence(s)
      AC008482, AK095818, AW302247, BC047581, CN348312, DA803910, DB302918
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Related
      ENSP00000296783.3, ENST00000296783.7
      Conserved Domains (1) summary
      COG5260
      Location:154468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      79612441..79688246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011543221.4XP_011541523.1  poly(A) RNA polymerase GLD2 isoform X1

      See identical proteins and their annotated locations for XP_011541523.1

      Conserved Domains (1) summary
      COG5260
      Location:154493
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    2. XM_047416850.1XP_047272806.1  poly(A) RNA polymerase GLD2 isoform X3

      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
    3. XM_047416857.1XP_047272813.1  poly(A) RNA polymerase GLD2 isoform X6

      UniProtKB/TrEMBL
      D6RAF2
    4. XM_047416846.1XP_047272802.1  poly(A) RNA polymerase GLD2 isoform X2

    5. XM_011543220.4XP_011541522.1  poly(A) RNA polymerase GLD2 isoform X1

      See identical proteins and their annotated locations for XP_011541522.1

      Conserved Domains (1) summary
      COG5260
      Location:154493
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    6. XM_047416856.1XP_047272812.1  poly(A) RNA polymerase GLD2 isoform X6

      UniProtKB/TrEMBL
      D6RAF2
    7. XM_017009152.3XP_016864641.1  poly(A) RNA polymerase GLD2 isoform X2

      Conserved Domains (1) summary
      COG5260
      Location:154489
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    8. XM_047416859.1XP_047272815.1  poly(A) RNA polymerase GLD2 isoform X7

    9. XM_011543229.4XP_011541531.1  poly(A) RNA polymerase GLD2 isoform X5

      Conserved Domains (2) summary
      cd05402
      Location:176323
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:368422
      PAP_assoc; Cid1 family poly A polymerase
    10. XM_047416851.1XP_047272807.1  poly(A) RNA polymerase GLD2 isoform X3

      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
    11. XM_047416853.1XP_047272809.1  poly(A) RNA polymerase GLD2 isoform X4

    12. XM_047416844.1XP_047272800.1  poly(A) RNA polymerase GLD2 isoform X1

    13. XM_047416852.1XP_047272808.1  poly(A) RNA polymerase GLD2 isoform X3

      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
    14. XM_047416848.1XP_047272804.1  poly(A) RNA polymerase GLD2 isoform X2

    15. XM_047416854.1XP_047272810.1  poly(A) RNA polymerase GLD2 isoform X4

    16. XM_011543225.3XP_011541527.1  poly(A) RNA polymerase GLD2 isoform X1

      See identical proteins and their annotated locations for XP_011541527.1

      Conserved Domains (1) summary
      COG5260
      Location:154493
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    17. XM_047416858.1XP_047272814.1  poly(A) RNA polymerase GLD2 isoform X6

      UniProtKB/TrEMBL
      D6RAF2
    18. XM_047416845.1XP_047272801.1  poly(A) RNA polymerase GLD2 isoform X1

    19. XM_047416849.1XP_047272805.1  poly(A) RNA polymerase GLD2 isoform X2

    20. XM_047416855.1XP_047272811.1  poly(A) RNA polymerase GLD2 isoform X4

    21. XM_011543224.3XP_011541526.1  poly(A) RNA polymerase GLD2 isoform X1

      See identical proteins and their annotated locations for XP_011541526.1

      Conserved Domains (1) summary
      COG5260
      Location:154493
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    22. XM_047416847.1XP_047272803.1  poly(A) RNA polymerase GLD2 isoform X2

    23. XM_047416862.1XP_047272818.1  poly(A) RNA polymerase GLD2 isoform X10

    24. XM_047416860.1XP_047272816.1  poly(A) RNA polymerase GLD2 isoform X8

    25. XM_047416861.1XP_047272817.1  poly(A) RNA polymerase GLD2 isoform X9

    26. XM_047416864.1XP_047272820.1  poly(A) RNA polymerase GLD2 isoform X11

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      80096704..80172520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351881.1XP_054207856.1  poly(A) RNA polymerase GLD2 isoform X1

    2. XM_054351891.1XP_054207866.1  poly(A) RNA polymerase GLD2 isoform X3

      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
    3. XM_054351899.1XP_054207874.1  poly(A) RNA polymerase GLD2 isoform X6

      UniProtKB/TrEMBL
      D6RAF2
    4. XM_054351887.1XP_054207862.1  poly(A) RNA polymerase GLD2 isoform X2

    5. XM_054351880.1XP_054207855.1  poly(A) RNA polymerase GLD2 isoform X1

    6. XM_054351898.1XP_054207873.1  poly(A) RNA polymerase GLD2 isoform X6

      UniProtKB/TrEMBL
      D6RAF2
    7. XM_054351886.1XP_054207861.1  poly(A) RNA polymerase GLD2 isoform X2

    8. XM_054351901.1XP_054207876.1  poly(A) RNA polymerase GLD2 isoform X7

    9. XM_054351897.1XP_054207872.1  poly(A) RNA polymerase GLD2 isoform X5

    10. XM_054351892.1XP_054207867.1  poly(A) RNA polymerase GLD2 isoform X3

      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
    11. XM_054351894.1XP_054207869.1  poly(A) RNA polymerase GLD2 isoform X4

    12. XM_054351884.1XP_054207859.1  poly(A) RNA polymerase GLD2 isoform X1

    13. XM_054351893.1XP_054207868.1  poly(A) RNA polymerase GLD2 isoform X3

      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
    14. XM_054351889.1XP_054207864.1  poly(A) RNA polymerase GLD2 isoform X2

    15. XM_054351895.1XP_054207870.1  poly(A) RNA polymerase GLD2 isoform X4

    16. XM_054351883.1XP_054207858.1  poly(A) RNA polymerase GLD2 isoform X1

    17. XM_054351900.1XP_054207875.1  poly(A) RNA polymerase GLD2 isoform X6

      UniProtKB/TrEMBL
      D6RAF2
    18. XM_054351885.1XP_054207860.1  poly(A) RNA polymerase GLD2 isoform X1

    19. XM_054351890.1XP_054207865.1  poly(A) RNA polymerase GLD2 isoform X2

    20. XM_054351896.1XP_054207871.1  poly(A) RNA polymerase GLD2 isoform X4

    21. XM_054351882.1XP_054207857.1  poly(A) RNA polymerase GLD2 isoform X1

    22. XM_054351888.1XP_054207863.1  poly(A) RNA polymerase GLD2 isoform X2

    23. XM_054351906.1XP_054207881.1  poly(A) RNA polymerase GLD2 isoform X11

    24. XM_054351904.1XP_054207879.1  poly(A) RNA polymerase GLD2 isoform X10

    25. XM_054351902.1XP_054207877.1  poly(A) RNA polymerase GLD2 isoform X8

    26. XM_054351903.1XP_054207878.1  poly(A) RNA polymerase GLD2 isoform X9

    27. XM_054351905.1XP_054207880.1  poly(A) RNA polymerase GLD2 isoform X11