U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    ARL6IP6 ADP ribosylation factor like GTPase 6 interacting protein 6 [ Homo sapiens (human) ]

    Gene ID: 151188, updated on 5-Mar-2024

    Summary

    Official Symbol
    ARL6IP6provided by HGNC
    Official Full Name
    ADP ribosylation factor like GTPase 6 interacting protein 6provided by HGNC
    Primary source
    HGNC:HGNC:24048
    See related
    Ensembl:ENSG00000177917 MIM:616495; AllianceGenome:HGNC:24048
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AIP6; AIP-6; PFAAP1
    Summary
    Predicted to be located in nuclear inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta (RPKM 7.1), bone marrow (RPKM 6.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ARL6IP6 in Genome Data Viewer
    Location:
    2q23.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (152717648..152762396)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (153170194..153214953)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (153574162..153618910)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373689 Neighboring gene uncharacterized LOC105373688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:153183153-153183652 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12011 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:153258063-153258564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:153258565-153259064 Neighboring gene Sharpr-MPRA regulatory region 2662 Neighboring gene formin like 2 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:153280187-153280913 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:153280914-153281639 Neighboring gene Sharpr-MPRA regulatory region 469 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:153309665-153310256 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:153310257-153310847 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:153312623-153313213 Neighboring gene nuclear distribution C pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:153357706-153358281 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16649 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:153474731-153475930 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:153502126-153503325 Neighboring gene NANOG hESC enhancer GRCh37_chr2:153508427-153509132 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:153519134-153520333 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16650 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:153557503-153558702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:153558975-153559476 Neighboring gene pre-mRNA processing factor 40 homolog A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16651 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16656 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16655 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:153574523-153575228 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:153661367-153661578 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:153702825-153704024 Neighboring gene ubiquilin 4 pseudogene 2 Neighboring gene uncharacterized LOC105373691 Neighboring gene NANOG hESC enhancer GRCh37_chr2:153842337-153842838

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC33864

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nuclear inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ADP-ribosylation factor-like protein 6-interacting protein 6
    Names
    ADP-ribosylation factor GTPase 6 interacting protein 6
    ADP-ribosylation factor-like 6 interacting protein 6
    ADP-ribosylation-like factor 6 interacting protein 6
    ARL-6-interacting protein 6
    phosphonoformate immuno-associated protein 1
    regulated by phosphonoformate

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053091.1 RefSeqGene

      Range
      5928..49704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001350068.2NP_001336997.1  ADP-ribosylation factor-like protein 6-interacting protein 6 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC079344
      Conserved Domains (1) summary
      pfam15062
      Location:42118
      ARL6IP6; Haemopoietic lineage transmembrane helix
    2. NM_001371972.1NP_001358901.1  ADP-ribosylation factor-like protein 6-interacting protein 6 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC079344
      Consensus CDS
      CCDS92880.1
      UniProtKB/TrEMBL
      A0A8I5KQ30, B3KMZ5
      Related
      ENSP00000509648.1, ENST00000686080.1
      Conserved Domains (1) summary
      pfam15062
      Location:147183
      ARL6IP6; Haemopoietic lineage transmembrane helix
    3. NM_152522.7NP_689735.1  ADP-ribosylation factor-like protein 6-interacting protein 6 isoform a

      See identical proteins and their annotated locations for NP_689735.1

      Status: VALIDATED

      Source sequence(s)
      AC079344
      Consensus CDS
      CCDS2197.1
      UniProtKB/Swiss-Prot
      B2RDS6, Q7Z4G7, Q8N6S5
      UniProtKB/TrEMBL
      B3KMZ5
      Related
      ENSP00000315357.5, ENST00000326446.10
      Conserved Domains (1) summary
      pfam15062
      Location:138214
      ARL6IP6; Haemopoietic lineage transmembrane helix

    RNA

    1. NR_024526.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC079344
    2. NR_146422.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC079344
    3. NR_146423.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC079344
    4. NR_146424.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC079344
    5. NR_146425.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC079344
    6. NR_146426.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC079344
    7. NR_146427.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC079344
    8. NR_146428.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC079344
    9. NR_146429.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC079344
    10. NR_146430.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC079344
    11. NR_146431.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC079344

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      152717648..152762396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_007069661.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      153170194..153214953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008486292.1 RNA Sequence