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    ADRA2A adrenoceptor alpha 2A [ Homo sapiens (human) ]

    Gene ID: 150, updated on 11-Apr-2024

    Summary

    Official Symbol
    ADRA2Aprovided by HGNC
    Official Full Name
    adrenoceptor alpha 2Aprovided by HGNC
    Primary source
    HGNC:HGNC:281
    See related
    Ensembl:ENSG00000150594 MIM:104210; AllianceGenome:HGNC:281
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADRA2; ADRAR; FPLD8; ZNF32; ADRA2R; ALPHA2AAR
    Summary
    Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. The alpha-2-adrenergic receptors are a type of adrenergic receptors (for adrenaline or epinephrine), which inhibit adenylate cyclase. These receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. They are involved in regulating the release of neurotransmitter molecules from sympathetic nerves and from adrenergic neurons in the central nervous system. The sympathetic nervous system regulates cardiovascular function by activating adrenergic receptors in the heart, blood vessels and kidney. Studies in mouse revealed that both the alpha2A and alpha2C receptor subtypes were required for presynaptic transmitter release from the sympathetic nervous system in the heart and from central noradrenergic neurons. The alpha-2-adrenergic receptors are also involved in catecholamine signaling by extracellular regulated protein kinase 1 and 2 (ERK1/2) pathways. A clear association between the alpha-2-adrenergic receptor and disease has not been yet established. [provided by RefSeq, Sep 2019]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ADRA2A in Genome Data Viewer
    Location:
    10q25.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (111077029..111080907)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (111960874..111964752)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (112836787..112840665)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene SHOC2 leucine rich repeat scaffold protein Neighboring gene ribosomal protein L13a pseudogene 6 Neighboring gene microRNA 548e Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2830 Neighboring gene chromosome 19 open reading frame 53 pseudogene Neighboring gene HEart disease Associated Transcript 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Lipodystrophy, familial partial, type 8
    MedGen: CN376064 OMIM: 620679 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
    EBI GWAS Catalog
    Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.
    EBI GWAS Catalog
    New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alpha-1B adrenergic receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables alpha-2C adrenergic receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables alpha2-adrenergic receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables alpha2-adrenergic receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables alpha2-adrenergic receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables epinephrine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables epinephrine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heterotrimeric G-protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables norepinephrine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables thioesterase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in Ras protein signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in Rho protein signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in actin cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in activation of protein kinase B activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in activation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in adenylate cyclase-inhibiting adrenergic receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adrenergic receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to hormone stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in fear response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intestinal absorption TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of calcium ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of calcium ion-dependent exocytosis IC
    Inferred by Curator
    more info
    PubMed 
    involved_in negative regulation of epinephrine secretion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of lipid catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of norepinephrine secretion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of norepinephrine secretion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of uterine smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipase C-activating adrenergic receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in platelet activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of potassium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor transactivation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thermoception IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vasodilation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon terminus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dopaminergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynaptic active zone membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    alpha-2A adrenergic receptor
    Names
    adrenergic, alpha-2A-, receptor
    alpha-2 adrenergic receptor subtype C10
    alpha-2-adrenergic receptor, platelet type
    alpha-2A adrenoceptor
    alpha-2A adrenoreceptor
    alpha-2AAR subtype C10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012020.1 RefSeqGene

      Range
      4998..8876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_545

    mRNA and Protein(s)

    1. NM_000681.4NP_000672.3  alpha-2A adrenergic receptor

      See identical proteins and their annotated locations for NP_000672.3

      Status: REVIEWED

      Source sequence(s)
      AF284095, AL158163, BM682651
      Consensus CDS
      CCDS7569.2
      UniProtKB/Swiss-Prot
      B0LPF6, P08913, Q2I8G2, Q2XN99, Q86TH8, Q9BZK1
      Related
      ENSP00000280155.2, ENST00000280155.4
      Conserved Domains (2) summary
      PHA03307
      Location:244389
      PHA03307; transcriptional regulator ICP4; Provisional
      cd15322
      Location:49452
      7tmA_alpha2A_AR; alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      111077029..111080907
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      111960874..111964752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)