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Adra2a adrenergic receptor, alpha 2a [ Mus musculus (house mouse) ]

Gene ID: 11551, updated on 8-Feb-2024

Summary

Official Symbol
Adra2aprovided by MGI
Official Full Name
adrenergic receptor, alpha 2aprovided by MGI
Primary source
MGI:MGI:87934
See related
Ensembl:ENSMUSG00000033717 AllianceGenome:MGI:87934
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adra-2; Adra-2a; alpha2A; alpha2-C10; alpha2A-AR; alpha(2A)AR
Summary
Enables adrenergic receptor activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within G protein-coupled receptor signaling pathway and fear response. Is active in dopaminergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb segment; and sensory organ. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and type 2 diabetes mellitus. Orthologous to human ADRA2A (adrenoceptor alpha 2A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Adra2a in Genome Data Viewer
Location:
19 D2; 19 49.04 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (54033690..54037413)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (54045259..54048982)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30990 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:53968181-53968334 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:53968382-53968491 Neighboring gene STARR-positive B cell enhancer ABC_E622 Neighboring gene STARR-seq mESC enhancer starr_46471 Neighboring gene programmed cell death 4 Neighboring gene STARR-seq mESC enhancer starr_46472 Neighboring gene STARR-seq mESC enhancer starr_46473 Neighboring gene BBSome interacting protein 1 Neighboring gene Shoc2, leucine rich repeat scaffold protein Neighboring gene STARR-seq mESC enhancer starr_46474 Neighboring gene STARR-seq mESC enhancer starr_46476 Neighboring gene STARR-seq mESC enhancer starr_46477 Neighboring gene predicted gene, 41865 Neighboring gene predicted gene, 41866

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Chemically induced (ENU) (2) 
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables adrenergic receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables alpha-2C adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables alpha2-adrenergic receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables alpha2-adrenergic receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables alpha2-adrenergic receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables alpha2-adrenergic receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables epinephrine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables epinephrine binding ISO
Inferred from Sequence Orthology
more info
 
enables heterotrimeric G-protein binding ISO
Inferred from Sequence Orthology
more info
 
enables norepinephrine binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables thioesterase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA replication ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-inhibiting adrenergic receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adrenergic receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in female pregnancy ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of uterine smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipase C-activating adrenergic receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet activation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
involved_in presynaptic modulation of chemical synaptic transmission EXP
Inferred from Experiment
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor transactivation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in thermoception ISO
Inferred from Sequence Orthology
more info
 
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in dopaminergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in dopaminergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dopaminergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
alpha-2A adrenergic receptor
Names
alpha-2A adrenoceptor
alpha-2A adrenoreceptor
alpha-2AAR
alpha2A-adrenergic receptor
subtype alpha2-C10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007417.5NP_031443.4  alpha-2A adrenergic receptor

    See identical proteins and their annotated locations for NP_031443.4

    Status: VALIDATED

    Source sequence(s)
    AC113491
    Consensus CDS
    CCDS29905.1
    UniProtKB/Swiss-Prot
    Q01338, Q3URE6
    UniProtKB/TrEMBL
    Q1HL33
    Related
    ENSMUSP00000036203.6, ENSMUST00000036700.7
    Conserved Domains (1) summary
    cd15322
    Location:49452
    7tmA_alpha2A_AR; alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    54033690..54037413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)