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    Pdia3 protein disulfide isomerase associated 3 [ Mus musculus (house mouse) ]

    Gene ID: 14827, updated on 10-Aug-2021

    Summary

    Official Symbol
    Pdia3provided by MGI
    Official Full Name
    protein disulfide isomerase associated 3provided by MGI
    Primary source
    MGI:MGI:95834
    See related
    Ensembl:ENSMUSG00000027248
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E; P; Erp; Grp; PDI; PDI-; Plca; 58kDa; ERp57; ERp60; ERp61; Grp58; PDI-Q2; PI-PLC; PLC[a]
    Expression
    Ubiquitous expression in placenta adult (RPKM 203.6), ovary adult (RPKM 132.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pdia3 in Genome Data Viewer
    Location:
    2 E5; 2 60.38 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121244383..121269168)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121413902..121438687)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (121239638..121264423)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 33947 Neighboring gene creatine kinase, mitochondrial 1, ubiquitous Neighboring gene stereocilin Neighboring gene cation channel, sperm associated 2 Neighboring gene elongation factor RNA polymerase II-like 3 Neighboring gene serine incorporator 4 Neighboring gene small EDRK-rich factor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC class I protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein-disulfide reductase (glutathione) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-disulfide reductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of MHC class I peptide loading complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of TAP complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in smooth endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein disulfide-isomerase A3
    Names
    58 kDa glucose-regulated protein
    58 kDa microsomal protein
    ER protein 57
    ER protein 60
    disulfide isomerase ER-60
    endoplasmic reticulum protein
    endoplasmic reticulum resident protein 57
    endoplasmic reticulum resident protein 60
    glucose regulated protein, 58 kDa
    p58
    phospholipase C, alpha
    NP_031978.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007952.2NP_031978.2  protein disulfide-isomerase A3 precursor

      See identical proteins and their annotated locations for NP_031978.2

      Status: VALIDATED

      Source sequence(s)
      AK132459, AK133799, AL845466, BQ033063, BQ714617
      Consensus CDS
      CCDS16643.1
      UniProtKB/Swiss-Prot
      P27773
      Related
      ENSMUSP00000028683.8, ENSMUST00000028683.14
      Conserved Domains (5) summary
      cd02995
      Location:377480
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      cd03069
      Location:135240
      PDI_b_ERp57; PDIb family, ERp57 subfamily, first redox inactive TRX-like domain b; ERp57 (or ERp60) exhibits both disulfide oxidase and reductase functions like PDI, by catalyzing the formation of disulfide bonds of newly synthesized polypeptides in the ER and acting ...
      cd03073
      Location:244357
      PDI_b'_ERp72_ERp57; PDIb' family, ERp72 and ERp57 subfamily, second redox inactive TRX-like domain b'; ERp72 and ER57 are involved in oxidative protein folding in the ER, like PDI. They exhibit both disulfide oxidase and reductase functions, by catalyzing the formation of ...
      TIGR01130
      Location:26487
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      pfam00085
      Location:27131
      Thioredoxin; Thioredoxin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      121244383..121269168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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