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    Pdia3 protein disulfide isomerase associated 3 [ Mus musculus (house mouse) ]

    Gene ID: 14827, updated on 6-Nov-2018

    Summary

    Official Symbol
    Pdia3provided by MGI
    Official Full Name
    protein disulfide isomerase associated 3provided by MGI
    Primary source
    MGI:MGI:95834
    See related
    Ensembl:ENSMUSG00000027248 Vega:OTTMUSG00000015325
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Erp; PDI; Plca; 58kDa; ERp57; ERp60; ERp61; Grp58; PDI-Q2; PI-PLC; PLC[a]
    Expression
    Ubiquitous expression in placenta adult (RPKM 203.6), ovary adult (RPKM 132.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Pdia3 in Genome Data Viewer
    Location:
    2 E5; 2 60.38 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (121413902..121438687)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (121239638..121264423)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33947 Neighboring gene creatine kinase, mitochondrial 1, ubiquitous Neighboring gene stereocilin Neighboring gene cation channel, sperm associated 2 Neighboring gene elongation factor RNA polymerase II-like 3 Neighboring gene serine incorporator 4 Neighboring gene small EDRK-rich factor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    MHC class I protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptide disulfide oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein-disulfide reductase (glutathione) activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to vitamin D ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    MHC class I peptide loading complex ISO
    Inferred from Sequence Orthology
    more info
     
    TAP complex ISO
    Inferred from Sequence Orthology
    more info
     
    acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    smooth endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein disulfide-isomerase A3
    Names
    58 kDa glucose-regulated protein
    58 kDa microsomal protein
    ER protein 57
    ER protein 60
    disulfide isomerase ER-60
    endoplasmic reticulum protein
    endoplasmic reticulum resident protein 57
    endoplasmic reticulum resident protein 60
    glucose regulated protein, 58 kDa
    p58
    phospholipase C, alpha
    NP_031978.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007952.2NP_031978.2  protein disulfide-isomerase A3 precursor

      See identical proteins and their annotated locations for NP_031978.2

      Status: VALIDATED

      Source sequence(s)
      AK132459, AK133799, AL845466, BQ033063, BQ714617
      Consensus CDS
      CCDS16643.1
      UniProtKB/Swiss-Prot
      P27773
      Related
      ENSMUSP00000028683.7, OTTMUSP00000016318, ENSMUST00000028683.13, OTTMUST00000036322
      Conserved Domains (5) summary
      cd02995
      Location:377480
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      cd03069
      Location:135240
      PDI_b_ERp57; PDIb family, ERp57 subfamily, first redox inactive TRX-like domain b; ERp57 (or ERp60) exhibits both disulfide oxidase and reductase functions like PDI, by catalyzing the formation of disulfide bonds of newly synthesized polypeptides in the ER and acting ...
      cd03073
      Location:244357
      PDI_b'_ERp72_ERp57; PDIb' family, ERp72 and ERp57 subfamily, second redox inactive TRX-like domain b'; ERp72 and ER57 are involved in oxidative protein folding in the ER, like PDI. They exhibit both disulfide oxidase and reductase functions, by catalyzing the formation of ...
      TIGR01130
      Location:26487
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      pfam00085
      Location:27131
      Thioredoxin; Thioredoxin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      121413902..121438687
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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