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    Gpi1 glucose-6-phosphate isomerase 1 [ Mus musculus (house mouse) ]

    Gene ID: 14751, updated on 23-Jun-2021

    Summary

    Official Symbol
    Gpi1provided by MGI
    Official Full Name
    glucose-6-phosphate isomerase 1provided by MGI
    Primary source
    MGI:MGI:95797
    See related
    Ensembl:ENSMUSG00000036427
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    N; O; AM; MF; NK; Amf; Gpi; NK/; Nlk; Org; Pgi; Phi; Gpi-; Gpi-1; Gpi1s; neuro; Gpi-1r; Gpi-1s; Gpi-1t; Gpi1-r; Gpi1-s; Gpi1-t; NK/GPI
    Summary
    This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. [provided by RefSeq, Aug 2016]
    Expression
    Ubiquitous expression in testis adult (RPKM 145.1), duodenum adult (RPKM 123.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Gpi1 in Genome Data Viewer
    Location:
    7 B1; 7 19.46 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (33900752..33929761, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (34201327..34230336, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (34986346..35015324, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene programmed cell death 2-like Neighboring gene predicted gene 12762 Neighboring gene predicted gene 12758 Neighboring gene granule associated Rac and RHOG effector 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC113776

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glucose-6-phosphate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables glucose-6-phosphate isomerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glucose-6-phosphate isomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables glucose-6-phosphate isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables monosaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables monosaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in canonical glycolysis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in carbohydrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within erythrocyte homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in glucose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in glucose 6-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within glycolytic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glycolytic process through glucose-6-phosphate IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mesoderm formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of immunoglobulin production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to morphine ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in ciliary membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space HDA PubMed 
    located_in myelin sheath HDA PubMed 
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glucose-6-phosphate isomerase
    Names
    autocrine motility factor
    glucose phosphate isomerase 1 complex
    glucose phosphate isomerase 1, regulatory
    glucose phosphate isomerase 1, structural
    glucose phosphate isomerase 1, temporal
    maturation factor
    neuroleukin
    phosphoglucose isomerase
    phosphohexose isomerase
    NP_032181.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008155.4NP_032181.2  glucose-6-phosphate isomerase

      See identical proteins and their annotated locations for NP_032181.2

      Status: REVIEWED

      Source sequence(s)
      AK031081, AK147124, BY350616
      Consensus CDS
      CCDS21138.1
      UniProtKB/Swiss-Prot
      P06745
      Related
      ENSMUSP00000049355.5, ENSMUST00000038027.6
      Conserved Domains (3) summary
      PRK00179
      Location:1554
      pgi; glucose-6-phosphate isomerase; Reviewed
      cd05015
      Location:123286
      SIS_PGI_1; Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of ...
      cd05016
      Location:334525
      SIS_PGI_2; Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      33900752..33929761 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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