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    Fpgs folylpolyglutamyl synthetase [ Mus musculus (house mouse) ]

    Gene ID: 14287, updated on 9-Sep-2018

    Summary

    Official Symbol
    Fpgsprovided by MGI
    Official Full Name
    folylpolyglutamyl synthetaseprovided by MGI
    Primary source
    MGI:MGI:95576
    See related
    Ensembl:ENSMUSG00000009566 Vega:OTTMUSG00000012531
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA408187
    Expression
    Broad expression in liver adult (RPKM 116.7), ovary adult (RPKM 47.2) and 24 other tissues See more
    Orthologs

    Genomic context

    See Fpgs in Genome Data Viewer
    Location:
    2 B; 2 22.09 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (32682609..32704196, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (32538129..32549695, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene adenylate kinase 1 Neighboring gene endoglin Neighboring gene microRNA 1954 Neighboring gene microRNA 8093 Neighboring gene cyclin-dependent kinase 9 (CDC2-related kinase) Neighboring gene microRNA 2861

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    tetrahydrofolylpolyglutamate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tetrahydrofolylpolyglutamate synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    folic acid-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    folic acid-containing compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    glutamate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    tetrahydrofolylpolyglutamate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion HDA PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    folylpolyglutamate synthase, mitochondrial
    Names
    folylpoly-gamma-glutamate synthetase
    tetrahydrofolate synthase
    tetrahydrofolylpolyglutamate synthase
    NP_034366.2
    XP_006497759.2
    XP_006497760.1
    XP_006497761.3
    XP_011237323.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010236.2NP_034366.2  folylpolyglutamate synthase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_034366.2

      Status: VALIDATED

      Source sequence(s)
      BE627294, BM944126, BY025719, CA558410, CF749232
      Consensus CDS
      CCDS15926.1
      UniProtKB/Swiss-Prot
      P48760
      Related
      ENSMUSP00000028148.4, OTTMUSP00000013402, ENSMUST00000028148.10, OTTMUST00000029793
      Conserved Domains (2) summary
      PLN02881
      Location:44581
      PLN02881; tetrahydrofolylpolyglutamate synthase
      pfam02875
      Location:360441
      Mur_ligase_C; Mur ligase family, glutamate ligase domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      32682609..32704196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497697.3XP_006497760.1  folylpolyglutamate synthase, mitochondrial isoform X2

      Conserved Domains (2) summary
      PLN02881
      Location:39582
      PLN02881; tetrahydrofolylpolyglutamate synthase
      pfam02875
      Location:361442
      Mur_ligase_C; Mur ligase family, glutamate ligase domain
    2. XM_006497696.3XP_006497759.2  folylpolyglutamate synthase, mitochondrial isoform X1

      Conserved Domains (2) summary
      PLN02881
      Location:44586
      PLN02881; tetrahydrofolylpolyglutamate synthase
      pfam02875
      Location:365446
      Mur_ligase_C; Mur ligase family, glutamate ligase domain
    3. XM_006497698.3XP_006497761.3  folylpolyglutamate synthase, mitochondrial isoform X3

    4. XM_011239021.2XP_011237323.1  folylpolyglutamate synthase, mitochondrial isoform X4

      Conserved Domains (1) summary
      PLN02881
      Location:68421
      PLN02881; tetrahydrofolylpolyglutamate synthase

    RNA

    1. XR_001780795.1 RNA Sequence

      Related
      ENSMUST00000130164.7
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