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    Fpgs folylpolyglutamyl synthetase [ Mus musculus (house mouse) ]

    Gene ID: 14287, updated on 23-Jun-2021

    Summary

    Official Symbol
    Fpgsprovided by MGI
    Official Full Name
    folylpolyglutamyl synthetaseprovided by MGI
    Primary source
    MGI:MGI:95576
    See related
    Ensembl:ENSMUSG00000009566
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA408187
    Expression
    Broad expression in liver adult (RPKM 116.7), ovary adult (RPKM 47.2) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Fpgs in Genome Data Viewer
    Location:
    2 B; 2 22.09 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32572621..32594208, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32682609..32704196, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (32538129..32549695, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene endoglin Neighboring gene microRNA 1954 Neighboring gene predicted gene, 26236 Neighboring gene microRNA 8093 Neighboring gene cyclin-dependent kinase 9 (CDC2-related kinase) Neighboring gene microRNA 2861 Neighboring gene microRNA 3960

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tetrahydrofolylpolyglutamate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables tetrahydrofolylpolyglutamate synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in folic acid-containing compound biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in folic acid-containing compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glutamate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tetrahydrofolylpolyglutamate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in tetrahydrofolylpolyglutamate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    folylpolyglutamate synthase, mitochondrial
    Names
    folylpoly-gamma-glutamate synthetase
    tetrahydrofolate synthase
    tetrahydrofolylpolyglutamate synthase
    NP_034366.2
    XP_006497759.2
    XP_006497760.1
    XP_006497761.4
    XP_030103361.1
    XP_030103362.1
    XP_030103363.1
    XP_036014218.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010236.2NP_034366.2  folylpolyglutamate synthase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_034366.2

      Status: VALIDATED

      Source sequence(s)
      BE627294, BM944126, BY025719, CA558410, CF749232
      Consensus CDS
      CCDS15926.1
      UniProtKB/Swiss-Prot
      P48760
      Related
      ENSMUSP00000028148.5, ENSMUST00000028148.11
      Conserved Domains (2) summary
      PLN02881
      Location:44581
      PLN02881; tetrahydrofolylpolyglutamate synthase
      pfam02875
      Location:360441
      Mur_ligase_C; Mur ligase family, glutamate ligase domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      32572621..32594208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247502.1XP_030103362.1  folylpolyglutamate synthase, mitochondrial isoform X6

      Conserved Domains (1) summary
      PLN02881
      Location:1408
      PLN02881; tetrahydrofolylpolyglutamate synthase
    2. XM_030247501.1XP_030103361.1  folylpolyglutamate synthase, mitochondrial isoform X3

      Conserved Domains (1) summary
      PLN02881
      Location:39577
      PLN02881; tetrahydrofolylpolyglutamate synthase
    3. XM_006497697.3XP_006497760.1  folylpolyglutamate synthase, mitochondrial isoform X2

      Conserved Domains (1) summary
      PLN02881
      Location:39582
      PLN02881; tetrahydrofolylpolyglutamate synthase
    4. XM_006497698.4XP_006497761.4  folylpolyglutamate synthase, mitochondrial isoform X4

      Conserved Domains (1) summary
      PLN02881
      Location:44454
      PLN02881; tetrahydrofolylpolyglutamate synthase
    5. XM_036158325.1XP_036014218.1  folylpolyglutamate synthase, mitochondrial isoform X5

      Conserved Domains (1) summary
      PLN02881
      Location:44449
      PLN02881; tetrahydrofolylpolyglutamate synthase
    6. XM_006497696.5XP_006497759.2  folylpolyglutamate synthase, mitochondrial isoform X1

      Conserved Domains (1) summary
      PLN02881
      Location:44586
      PLN02881; tetrahydrofolylpolyglutamate synthase
    7. XM_030247503.2XP_030103363.1  folylpolyglutamate synthase, mitochondrial isoform X6

      Conserved Domains (1) summary
      PLN02881
      Location:1408
      PLN02881; tetrahydrofolylpolyglutamate synthase

    RNA

    1. XR_004938352.1 RNA Sequence

    2. XR_001780795.3 RNA Sequence

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