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    Drosha drosha, ribonuclease type III [ Mus musculus (house mouse) ]

    Gene ID: 14000, updated on 22-Aug-2021

    Summary

    Official Symbol
    Droshaprovided by MGI
    Official Full Name
    drosha, ribonuclease type IIIprovided by MGI
    Primary source
    MGI:MGI:1261425
    See related
    Ensembl:ENSMUSG00000022191
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    R; Rn3; Etoh; Etohi2; Rnasen; AI874853; 1110013A17Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 18.2), CNS E14 (RPKM 14.7) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Drosha in Genome Data Viewer
    Location:
    15; 15 A1
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (12824893..12935377)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (12824804..12935291)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (12754570..12865046)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6030458C11 gene Neighboring gene predicted gene, 41274 Neighboring gene cadherin 6 Neighboring gene predicted gene, 35018 Neighboring gene predicted gene, 46517

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC115770

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DEAD/H-box RNA helicase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables R-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables endoribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipopolysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables primary miRNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables primary miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribonuclease III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ribonuclease III activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within miRNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within pre-miRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in primary miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in primary miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in rRNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of miRNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of regulatory T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of microprocessor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ribonuclease 3
    Names
    RNase III
    ethanol induced 2
    protein Drosha
    ribonuclease III, nuclear
    NP_001123621.1
    NP_081075.3
    XP_006520084.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130149.1NP_001123621.1  ribonuclease 3

      See identical proteins and their annotated locations for NP_001123621.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK144147, BC088999, CA328055, U94841
      Consensus CDS
      CCDS49583.1
      UniProtKB/Swiss-Prot
      Q5HZJ0
      Related
      ENSMUSP00000129279.2, ENSMUST00000169061.8
      Conserved Domains (5) summary
      smart00358
      Location:12601331
      DSRM; Double-stranded RNA binding motif
      PRK00102
      Location:11041332
      rnc; ribonuclease III; Reviewed
      cd00593
      Location:11211253
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      pfam08648
      Location:217327
      DUF1777; Protein of unknown function (DUF1777)
      pfam12871
      Location:209289
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    2. NM_026799.3NP_081075.3  ribonuclease 3

      See identical proteins and their annotated locations for NP_081075.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC088999, CA328055, U94841
      Consensus CDS
      CCDS49583.1
      UniProtKB/Swiss-Prot
      Q5HZJ0
      Related
      ENSMUSP00000087762.6, ENSMUST00000090292.13
      Conserved Domains (5) summary
      smart00358
      Location:12601331
      DSRM; Double-stranded RNA binding motif
      PRK00102
      Location:11041332
      rnc; ribonuclease III; Reviewed
      cd00593
      Location:11211253
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      pfam08648
      Location:217327
      DUF1777; Protein of unknown function (DUF1777)
      pfam12871
      Location:209289
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      12824893..12935377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520021.4XP_006520084.1  ribonuclease 3 isoform X1

      Conserved Domains (3) summary
      PRK00102
      Location:11241352
      rnc; ribonuclease III; Reviewed
      cd00593
      Location:9781098
      RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
      pfam12871
      Location:231300
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term

    RNA

    1. XR_383823.3 RNA Sequence

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