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DROSHA drosha ribonuclease III [ Homo sapiens (human) ]

Gene ID: 29102, updated on 9-Dec-2024

Summary

Official Symbol
DROSHAprovided by HGNC
Official Full Name
drosha ribonuclease IIIprovided by HGNC
Primary source
HGNC:HGNC:17904
See related
Ensembl:ENSG00000113360 MIM:608828; AllianceGenome:HGNC:17904
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RN3; ETOHI2; RNASEN; RANSE3L; RNASE3L; HSA242976
Summary
This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016]
Expression
Ubiquitous expression in brain (RPKM 9.5), ovary (RPKM 7.6) and 25 other tissues See more
Orthologs
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Genomic context

See DROSHA in Genome Data Viewer
Location:
5p13.3
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (31400494..31532093, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (31514128..31645804, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (31400601..31532200, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374709 Neighboring gene cadherin 6 Neighboring gene double homeobox 4 like 51 (pseudogene) Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:31342590-31343789 Neighboring gene NANOG hESC enhancer GRCh37_chr5:31427117-31427643 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:31452968-31453512 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_84469 Neighboring gene Sharpr-MPRA regulatory region 6191 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:31493720-31494220 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_84483 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22433 Neighboring gene chromosome 5 open reading frame 22 Neighboring gene RNA, U6 small nuclear 363, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Knockdown of Drosha by shRNA leads to inhibit enrichment of HIV-1 Gag in intracellular vacuoles, but enhance viral particle release in Gag expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DEAD/H-box RNA helicase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables R-SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA binding HDA PubMed 
enables RNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables primary miRNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables primary miRNA binding NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ribonuclease III activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ribonuclease III activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in pre-miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in primary miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in primary miRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in primary miRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of miRNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of regulatory T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
part_of microprocessor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of microprocessor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of microprocessor complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ribonuclease 3
Names
RNase III
drosha, double-stranded RNA-specific endoribonuclease
nuclear RNase III Drosha
p241
putative protein p241 which interacts with transcription factor Sp1
putative ribonuclease III
ribonuclease type III, nuclear
NP_001093882.1
NP_001369437.1
NP_037367.3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051574.1 RefSeqGene

    Range
    5083..136682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001100412.2NP_001093882.1  ribonuclease 3 isoform 2

    See identical proteins and their annotated locations for NP_001093882.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AA917625, AC008768, BC024261, BX647724, DB065470
    Consensus CDS
    CCDS47194.1
    Related
    ENSP00000424161.1, ENST00000513349.5
    Conserved Domains (3) summary
    PRK00102
    Location:10681296
    rnc; ribonuclease III; Reviewed
    cd00593
    Location:9221042
    RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
    TIGR01642
    Location:217344
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
  2. NM_001382508.1NP_001369437.1  ribonuclease 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AC008768, AC022417, AC106802
    Consensus CDS
    CCDS47195.1
    UniProtKB/Swiss-Prot
    E7EMP9, Q7Z5V2, Q86YH0, Q9NRR4, Q9NW73, Q9Y2V9, Q9Y4Y0
    Related
    ENSP00000339845.3, ENST00000344624.8
    Conserved Domains (3) summary
    PRK00102
    Location:11051333
    rnc; ribonuclease III; Reviewed
    cd00593
    Location:9591079
    RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
    TIGR01642
    Location:217317
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
  3. NM_013235.5NP_037367.3  ribonuclease 3 isoform 1

    See identical proteins and their annotated locations for NP_037367.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AA917625, AC008768, AF189011, BC024261, DB065470
    Consensus CDS
    CCDS47195.1
    UniProtKB/Swiss-Prot
    E7EMP9, Q7Z5V2, Q86YH0, Q9NRR4, Q9NW73, Q9Y2V9, Q9Y4Y0
    Related
    ENSP00000425979.2, ENST00000511367.6
    Conserved Domains (3) summary
    PRK00102
    Location:11051333
    rnc; ribonuclease III; Reviewed
    cd00593
    Location:9591079
    RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
    TIGR01642
    Location:217317
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    31400494..31532093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    31514128..31645804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)