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    AAMP angio associated migratory cell protein [ Homo sapiens (human) ]

    Gene ID: 14, updated on 9-Jun-2024

    Summary

    Official Symbol
    AAMPprovided by HGNC
    Official Full Name
    angio associated migratory cell proteinprovided by HGNC
    Primary source
    HGNC:HGNC:18
    See related
    Ensembl:ENSG00000127837 MIM:603488; AllianceGenome:HGNC:18
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The gene is a member of the immunoglobulin superfamily. The encoded protein is associated with angiogenesis, with potential roles in endothelial tube formation and the migration of endothelial cells. It may also regulate smooth muscle cell migration via the RhoA pathway. The encoded protein can bind to heparin and may mediate heparin-sensitive cell adhesion. [provided by RefSeq, Oct 2014]
    Expression
    Ubiquitous expression in ovary (RPKM 40.5), thyroid (RPKM 38.1) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See AAMP in Genome Data Viewer
    Location:
    2q35
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (218264129..218270137, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (218749830..218755838, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219128852..219134860, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene actin related protein 2/3 complex subunit 2 Neighboring gene tRNA-Tyr (anticodon ATA) 1-1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:219126185-219126990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17115 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:219133153-219134038 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17116 Neighboring gene G protein-coupled bile acid receptor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17118 Neighboring gene PNKD metallo-beta-lactamase domain containing Neighboring gene transmembrane BAX inhibitor motif containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:219150593-219151401 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17119 Neighboring gene microRNA 6513 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:219154375-219154874 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:219155794-219156758 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:219156759-219157721 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:219157904-219158750 Neighboring gene uncharacterized LOC105373881 Neighboring gene uncharacterized LOC105373880

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition.
    EBI GWAS Catalog
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in smooth muscle cell migration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
     
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    angio-associated migratory cell protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033036.1 RefSeqGene

      Range
      5034..11042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001087.5NP_001078.2  angio-associated migratory cell protein isoform 2

      See identical proteins and their annotated locations for NP_001078.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
      Source sequence(s)
      BC008809, BC014122, DA465288, HY374777
      Consensus CDS
      CCDS33378.1
      UniProtKB/Swiss-Prot
      Q13685, Q8WUJ9, Q96H92
      UniProtKB/TrEMBL
      C9JG97
      Related
      ENSP00000248450.4, ENST00000248450.9
      Conserved Domains (3) summary
      smart00320
      Location:389427
      WD40; WD40 repeats
      cd00200
      Location:86386
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:94132
      7WD40; WD40 repeat [structural motif]
    2. NM_001302545.2NP_001289474.1  angio-associated migratory cell protein isoform 1

      See identical proteins and their annotated locations for NP_001289474.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC021016, AK225078, DA277259
      Consensus CDS
      CCDS77530.1
      UniProtKB/TrEMBL
      C9JEH3, C9JG97
      Related
      ENSP00000403343.1, ENST00000444053.5
      Conserved Domains (3) summary
      smart00320
      Location:390428
      WD40; WD40 repeats
      cd00200
      Location:87387
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:95133
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      218264129..218270137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      218749830..218755838 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)