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    Epn1 epsin 1 [ Mus musculus (house mouse) ]

    Gene ID: 13854, updated on 16-Nov-2018

    Summary

    Official Symbol
    Epn1provided by MGI
    Official Full Name
    epsin 1provided by MGI
    Primary source
    MGI:MGI:1333763
    See related
    Ensembl:ENSMUSG00000035203 Vega:OTTMUSG00000026130
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ibp1; AA269831
    Expression
    Ubiquitous expression in duodenum adult (RPKM 208.8), colon adult (RPKM 120.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Epn1 in Genome Data Viewer
    Location:
    7; 7 A1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (5080204..5098179)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (5031907..5049778)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 106 Neighboring gene predicted gene, 38940 Neighboring gene U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 Neighboring gene ret finger protein-like 4 Neighboring gene RAS-like, family 2, locus 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC106041

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    clathrin adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    ion channel binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic organ development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    female pregnancy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of clathrin coat assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    presynapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    epsin-1
    Names
    EPS-15-interacting protein 1
    intersectin-EH-binding protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252454.1NP_001239383.1  epsin-1

      See identical proteins and their annotated locations for NP_001239383.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI844312, BC046962, BC067206, CA750240
      Consensus CDS
      CCDS20758.1
      UniProtKB/Swiss-Prot
      Q80VP1
      Related
      ENSMUSP00000043340.6, OTTMUSP00000032066, ENSMUST00000045277.6, OTTMUST00000064529
      Conserved Domains (1) summary
      cd03571
      Location:19141
      ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    2. NM_010147.4NP_034277.1  epsin-1

      See identical proteins and their annotated locations for NP_034277.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI844312, BC046962, CA750240
      Consensus CDS
      CCDS20758.1
      UniProtKB/Swiss-Prot
      Q80VP1
      Related
      ENSMUSP00000096445.3, OTTMUSP00000032065, ENSMUST00000098845.9, OTTMUST00000064528
      Conserved Domains (1) summary
      cd03571
      Location:19141
      ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      5080204..5098179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539529.3XP_006539592.2  epsin-1 isoform X1

      See identical proteins and their annotated locations for XP_006539592.2

      UniProtKB/Swiss-Prot
      Q80VP1
      Conserved Domains (1) summary
      cd03571
      Location:19141
      ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    2. XM_006539532.3XP_006539595.2  epsin-1 isoform X2

      Conserved Domains (2) summary
      cd03571
      Location:19141
      ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
      pfam04871
      Location:124236
      Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
    3. XM_017321973.1XP_017177462.1  epsin-1 isoform X3

    4. XM_006539531.3XP_006539594.2  epsin-1 isoform X1

      See identical proteins and their annotated locations for XP_006539594.2

      UniProtKB/Swiss-Prot
      Q80VP1
      Conserved Domains (1) summary
      cd03571
      Location:19141
      ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    5. XM_006539533.1XP_006539596.1  epsin-1 isoform X1

      See identical proteins and their annotated locations for XP_006539596.1

      UniProtKB/Swiss-Prot
      Q80VP1
      Conserved Domains (1) summary
      cd03571
      Location:19141
      ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    6. XM_017321974.1XP_017177463.1  epsin-1 isoform X3

    7. XM_006539535.1XP_006539598.1  epsin-1 isoform X1

      See identical proteins and their annotated locations for XP_006539598.1

      UniProtKB/Swiss-Prot
      Q80VP1
      Conserved Domains (1) summary
      cd03571
      Location:19141
      ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    8. XM_006539534.1XP_006539597.1  epsin-1 isoform X1

      See identical proteins and their annotated locations for XP_006539597.1

      UniProtKB/Swiss-Prot
      Q80VP1
      Conserved Domains (1) summary
      cd03571
      Location:19141
      ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    9. XM_006539536.1XP_006539599.1  epsin-1 isoform X1

      See identical proteins and their annotated locations for XP_006539599.1

      UniProtKB/Swiss-Prot
      Q80VP1
      Related
      ENSMUSP00000146638.1, OTTMUSP00000076247, ENSMUST00000208634.1, OTTMUST00000146452
      Conserved Domains (1) summary
      cd03571
      Location:19141
      ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    10. XM_006539537.1XP_006539600.1  epsin-1 isoform X4

      Conserved Domains (1) summary
      cl02544
      Location:164
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
    11. XM_006539538.1XP_006539601.1  epsin-1 isoform X5

      Conserved Domains (1) summary
      PRK07764
      Location:74200
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
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