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    Copa coatomer protein complex subunit alpha [ Mus musculus (house mouse) ]

    Gene ID: 12847, updated on 23-Jun-2021

    Summary

    Official Symbol
    Copaprovided by MGI
    Official Full Name
    coatomer protein complex subunit alphaprovided by MGI
    Primary source
    MGI:MGI:1334462
    See related
    Ensembl:ENSMUSG00000026553
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    xe; xenin; AU040324
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 46.2), placenta adult (RPKM 40.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Copa in Genome Data Viewer
    Location:
    1 H3; 1 79.54 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171909885..171949899)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (172082529..172122332)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (174012660..174052463)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene VANGL planar cell polarity 2 Neighboring gene VISTA enhancer mm1677 Neighboring gene nescient helix loop helix 1 Neighboring gene nicastrin Neighboring gene peroxisomal biogenesis factor 19 Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of COPI vesicle coat ISO
    Inferred from Sequence Orthology
    more info
     
    located_in COPI-coated vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    coatomer subunit alpha
    Names
    alpha-COP
    alpha-coat protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009938.4NP_034068.3  coatomer subunit alpha

      See identical proteins and their annotated locations for NP_034068.3

      Status: VALIDATED

      Source sequence(s)
      AC158930, AK043479, AW537456, CF734857
      Consensus CDS
      CCDS35780.1
      UniProtKB/Swiss-Prot
      Q8CIE6
      UniProtKB/TrEMBL
      Q8BTF0
      Related
      ENSMUSP00000118179.2, ENSMUST00000135192.8
      Conserved Domains (5) summary
      COG2319
      Location:99504
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:9318
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam04053
      Location:339767
      Coatomer_WDAD; Coatomer WD associated region
      pfam06957
      Location:8161218
      COPI_C; Coatomer (COPI) alpha subunit C-terminus
      sd00039
      Location:1549
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      171909885..171949899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157379.1XP_036013272.1  coatomer subunit alpha isoform X1

      Related
      ENSMUSP00000027833.6, ENSMUST00000027833.12
      Conserved Domains (4) summary
      cd00200
      Location:9318
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:1549
      7WD40; WD40 repeat [structural motif]
      pfam04053
      Location:338776
      Coatomer_WDAD; Coatomer WD associated region
      pfam06957
      Location:8251227
      COPI_C; Coatomer (COPI) alpha subunit C-terminus
    2. XM_036157391.1XP_036013284.1  coatomer subunit alpha isoform X2

      Conserved Domains (2) summary
      pfam04053
      Location:24437
      Coatomer_WDAD; Coatomer WD associated region
      pfam06957
      Location:486888
      COPI_C; Coatomer (COPI) alpha subunit C-terminus
    3. XM_030245513.2XP_030101373.1  coatomer subunit alpha isoform X3

      Conserved Domains (2) summary
      pfam04053
      Location:24428
      Coatomer_WDAD; Coatomer WD associated region
      pfam06957
      Location:477879
      COPI_C; Coatomer (COPI) alpha subunit C-terminus
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