5A1U


Conserved Protein Domain Family
COPI_C
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pfam06957: COPI_C (this model, PSSM-Id:369149 is obsolete and has been replaced by 462050)
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Coatomer (COPI) alpha subunit C-terminus
This family represents the C-terminus (approximately 500 residues) of the eukaryotic coatomer alpha subunit. Coatomer (COPI) is a large cytosolic protein complex which forms a coat around vesicles budding from the Golgi apparatus. Such coatomer-coated vesicles have been proposed to play a role in many distinct steps of intracellular transport. Note that many family members also contain the pfam04053 domain.
Links
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Statistics
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PSSM-Id: 369149
Aligned: 34 rows
Threshold Bit Score: 511.039
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5A1U_C           816 GFFEGSIASKGKGGalAADIDIDt---VGTEGWGEDAELQLDE-------------DGFVEAPEGLGEdvlgKGQEEGGG 879  house mouse
Q9AUR8           816 GIFEGGLDATGKAE--L--EEDDe---AAGADWG-DEDLDMVDasea------manGGDGFDAEEGEAneedG---EEGG 878  Japanese rice
XP_004238316     816 GIFEGGLDSTVRGG--H--EEYEe---AADADWG--ESLDIGEven-------lqnGDISMVLDDEEGke-eND--EEGG 876  tomato
Q94A40           816 GIFEGGLESADRGG--TVDEEDV------EGDWG--EELDI-Nvdg-------menRDIEDILAAAEAgeeeND--EEGG 875  thale cress
ERM96351         816 GIFEGGLDNTGRGG--D--EEEEe---AAVADWG--EDLDIVEssg--------qnGHVDAEVEGGGEqe-eKS--EEGG 875  Amborella ...
ERN04739         604 GIFEGGLEN--RGK--TAHEGEEe---AADANWG--EDLEIIEmeg--------pnGDLE-IIGDEEViedgDG--EEGG 663  Amborella ...
jgi:OSTLU_24382  815 GFFEGVLSGEIAGD--EYAEDDVmgmgGVGLGWG-DADIDIGDdervd----plakAGIAPDVEFD------DVDNENDG 881  Ostreococc...
EEH57594         821 GFFEGVLSGEVDAS--AYAEGGFd--dEAGAGWGDDLDIDLGGdddkekeedplaaAGLAAGSDEEKEggdgSD--SDAG 894  Micromonas...
XP_002321558     816 GIFEGGLDNMGRGG--A--DEDEe---AADGDWG--EELDMVDvdg-------lqnGDVSAILEDGEAae-eNE--EEGG 876  black cott...
XP_009101857     822 GIFEGGLESAARGG--AVDEEEEe---DAGGDWG--DALDMVDvdg-------menRDIEAILAEAEGaeedND--EEGG 885  field mustard

5A1U_C           880 WDveEDLELPPELDVPSGVSgs---aeDGFFVPPTKGTSPTQIWCNNSQLPVDHILAGSFETAMRLLHDQVGVIQFGPYK 956  house mouse
Q9AUR8           879 WDl-EDLELPPEAETPKNAGna----rSAVFVAPPPGMPVSLIWTQKSSLAGEHAAAGNFDTAMRLLSRQLGIKNFAPLK 953  Japanese rice
XP_004238316     877 WDl-EDLDLPPDTDTPKTASna----rSSVFVTPNPGMPVSQIWVQKSSLAAEHAAAGNFDTAMRLLSRQLGIKNFSPLK 951  tomato
Q94A40           876 WGl-EDLVLPPELDTPKASAna----rSSVFVTPPQGMPVSQSWSQKSSLAAEQAAAGSFDTAMRLLHRQLGIKNFTPLK 950  thale cress
ERM96351         876 WDl-EDLELPPEVESANASTnv----rSTVFVAPTPGMPVSQIWTQKSSLAGEHAAAGNFDTAMRLLSRQLGIKNFAPLK 950  Amborella ...
ERN04739         664 WDl-EDLELPPELAAAANIAgir--lsNSSFVAPTPGMPVSQIWTQKSSLAGEHAAAGNFDTAMRLLSRQLGIRNFAPLK 740  Amborella ...
jgi:OSTLU_24382  882 WGm-DELELPEELMGGAVDDtgaetfhSDVFIAPTAGVPPSRRWTEKSAVAGEHVAAGDFDSAMKLLSRQLGIVNFAPLK 960  Ostreococc...
EEH57594         895 WDm-EDLDLPPDVGGGDDDGglv--gpSEVFVAPTAGIPPSRRWTEKSAVPGEHAAAGDFDAAMKLLNRQLGVINFAPLK 971  Micromonas...
XP_002321558     877 WDl-EDLELPPEADTPRASVsa----rSSVFVAPTPGMPVSQIWIQRSSLAAEHAAAGNFDTAMRLLNRQLGIKNFVPLK 951  black cott...
XP_009101857     886 WGelEGLDLPPELDTPKASAna----rSSVFVTPTQGMPVSHIWSQKSSLAAEQAAAGSFDTAMRLLNRQLGIKNFAPLK 961  field mustard

5A1U_C           957 QLFLQTYARGRTTYQALPCLPSMYSYPNRNWKDAGLKN--GVPAVGLKLNDLIQRLQLCYQLTTVG---KFEEAVEKFRS 1031 house mouse
Q9AUR8           954 PLFVDLHMGSHSYLRALATAPIIPIAVEKGWSESASPNvrGPPALVFTFPQMEDRLKAAYKATTDG---KFPEALRQFLS 1030 Japanese rice
XP_004238316     952 QLFADLHMGSHTYLRAFSSAPVISLAIERGWSETASPNvrGPPALIFNFSQLEEKLKTAYRATTSG---KFSDALRLFLS 1028 tomato
Q94A40           951 SMFLDLFNGSHSYLRAFSSCPVVPLAIERGWSESSSPNvrSPPALVYDFSQLDEKLKSGYKATTTG---KFTEALRLFLS 1027 thale cress
ERM96351         951 PFFLDLHMGSHSYLRAFASAPVVPIAVEKGWSESASPNvrAPPQLVYRFSMLDDKLRSAYKATTEG---KFTEALRLFLN 1027 Amborella ...
ERN04739         741 PLFMDLYLGSHAYLRGFPSAPLVPLAVERGWNEQGSANvrGPPAMVSKLSFLEERLKLAYKATTEG---KFAEALKLFLN 817  Amborella ...
jgi:OSTLU_24382  961 QHFVDLAYASHVTLEGMPASPKIPMPLGRGWSSRATGV--LPPAMICSPEILQERLKSAFKLTTEG---KFVEALKVFVG 1035 Ostreococc...
EEH57594         972 QHFIDAAFATHASMTATSMGPNLTFPLGRDWNADAPVGktPQPALVSSLAVLEAKLKAAYKTTTEG---KFGEALKLFQS 1048 Micromonas...
XP_002321558     952 SMFLDLYSGSHTYLRAFSSTPVISLAVERGWNESASPNvrGPPALVFNFSQLEEKLKAGYKATTTG---KFTEALRLFLG 1028 black cott...
XP_009101857     962 SMFIDLFSGSQSYLRAFSSSPVVPLAIERGWSESNSPNvrGPPALLYGFSQQEEKLKSGYKATTSGkdeKLTEALRLFLS 1041 field mustard

5A1U_C          1032 ILLSVPLLVVDNKQEIAEAQQLITICREYIVGLCMEIERKKLPketlDQQKRICEMAAYFTHSNLQPVHMILVLRTALNL 1111 house mouse
Q9AUR8          1031 ILHTIPLIVVDSRREVDEVKELIEIVREYVLGLRMELKRKELR----DDVNRQQELAAYFTNCKLQRVHMRLVLGSAMGL 1106 Japanese rice
XP_004238316    1029 ILHTIPLIVVESRREVDEVKELIVIVKEYVLGLQMEVKRKESK----DNPVRQQELAAYFTHCNLQLPHLRLALQNAMSI 1104 tomato
Q94A40          1028 ILHTIPLVVVETRREVDEVKELIVIVKEYVLGLQMELKRREMK----DDPVRQQELAAYFTHCNLQTPHLRLALLSAMGV 1103 thale cress
ERM96351        1028 ILHIIPVVVVDSRRDADEVKELIVIAKEYVLGLRMEVRRREVR----DDLKKQQELAAYFTHCNLQRIHLRLALMTAMGA 1103 Amborella ...
ERN04739         818 ILHLIPIIVVDSRREVDEVKELVVIAKEYVLALQMEVKRKELK----DDPVRQQELAAYFTHCNLQKVHLRLALMNAMGV 893  Amborella ...
jgi:OSTLU_24382 1036 IIHAITLLSVEDPSEVEDVEQLLKVAREYACALRIEIARKEVK----DDATRQAELAAYFTHSEMQPIHLSLSLRSAMSI 1111 Ostreococc...
EEH57594        1049 IIHGVAVLLVDSRREVDEVRELLGIAREYAVALRIEMKRKEHK----EDPVRAAELAAYFTHSMMQPIHASLALRSAMSL 1124 Micromonas...
XP_002321558    1029 ILHTIPLIVVDSRREVDEVKELIIIVKEYVLGLQMELKRREMK----DNPVRQQELAAYFTHCNLQAPHLRLALQNAMTV 1104 black cott...
XP_009101857    1042 ILHTIPLVVVESRSEVDEVKELVSIAKEYVVGLKMELKRRQKK----DDPVRQQELAAYFTHCNLQLPHLRLALLNAMTV 1117 field mustard

5A1U_C          1112 FFKLKNFKTAATFARRLLELGPK-PEVAQQTRKILSACEKNPTDACQLNYDMHNPFDICAASYRPIYRGKPVEKCPLSGA 1190 house mouse
Q9AUR8          1107 CYKQKNFATAEHFARMLLENNPN-EAQARRARQVQQQCS-GKKDSSELNYDYRNPFVVCGATYVPIYRGQKDVSCPYCGS 1184 Japanese rice
XP_004238316    1105 CYKASNLSSAANFARRLLETNPTnESQAKTARQVLQAAEKNMRDATELNYDFRNPFVVCGATYVPIYRGQKDVTCPYCTT 1184 tomato
Q94A40          1104 CYKAKNLATASNFARRLLETSPV-DSQAKMARQVVQAAERNMTDETKLNYDFRNPFVVCGSTYVPIYRGQKDVSCPYCTA 1182 thale cress
ERM96351        1104 CFKGGNYITAANFARRILETDPP-ANQATKARQLLQACERNMKDANELNYDFRNPFVVCGATFVPIYRGQKDVACPYCMA 1182 Amborella ...
ERN04739         894 CFKGNNYNTAANFARRLLETDPP-SNQASKARQVLQICERNPKDASQLNYDFRNPFILCGLTFVPIYHGQKSVLCPYCTA 972  Amborella ...
jgi:OSTLU_24382 1112 FFKLKNYVTAATFCRRLLELNPP-VKVATQAKQVLQACERAPKDEVEVNYDPHNPFAVCSATFVPIYKGTKDCVCPTCGA 1190 Ostreococc...
EEH57594        1125 FFKLKNFNTAANFCRRLLELNPP-VKVAQQAKQVLQACERTPTDEVELDYDSRNPFVVCSATFAPIYRGTKDVACSCCGA 1203 Micromonas...
XP_002321558    1105 CFKNKNLATAANFARRLLETNPPnENQARAARQVLAAAERSMTDAAQLNYDFRNPFVVCGATYVPIYRGQKDVSCPYCGS 1184 black cott...
XP_009101857    1118 CYKAKNLATAYNFAKRLLETNPL-ESHARAARQIVKAAERNMTDTTELNYDFRNPFVICGSTCVPIYRGQKDVSCPYCTA 1196 field mustard

5A1U_C          1191 CYSPE--FKGQICRVTTVTEIGKDVIGLRI 1218 house mouse
Q9AUR8          1185 RFVPS--IEGQLCTICELAVVGADASGLLC 1212 Japanese rice
XP_004238316    1185 HFVPS--QQGQLCTVCDLAVVGADASGLLC 1212 tomato
Q94A40          1183 RFVPN--QEGNICTVCDLAVIGADASGLLC 1210 thale cress
ERM96351        1183 RFVPV--LEGQLCPICDLAMVGSDASGLLC 1210 Amborella trichopoda
ERN04739         973 KFVPG--IEGQICTVCNLAVIGLDASGLVC 1000 Amborella trichopoda
jgi:OSTLU_24382 1191 HYVVE--EAGNVCGVCNLGKIGADATGLVC 1218 Ostreococcus lucimarinus CCE9901
EEH57594        1204 KFIAEgdHVNKVCPVCNLGAVGVEAAGLVV 1233 Micromonas pusilla CCMP1545
XP_002321558    1185 RFVPS--QEGQLCTVCDLAVVGADASGLLC 1212 black cottonwood
XP_009101857    1197 SFVPS--QEGNICGVGDIAVIGADASGLIC 1224 field mustard
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