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    Cntf ciliary neurotrophic factor [ Mus musculus (house mouse) ]

    Gene ID: 12803, updated on 12-Aug-2018

    Summary

    Official Symbol
    Cntfprovided by MGI
    Official Full Name
    ciliary neurotrophic factorprovided by MGI
    Primary source
    MGI:MGI:88439
    See related
    Ensembl:ENSMUSG00000079415 Vega:OTTMUSG00000024775
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI429687
    Summary
    The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes, and it may be involved in reducing tissue destruction during inflammatory attacks. A read-through transcript variant composed of Zfp91 and Cntf sequences has been identified, but it is thought to be non-coding. Read-through transcription of Zfp91 and Cntf has been observed in both human and mouse. [provided by RefSeq, Aug 2008]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 1.8), testis adult (RPKM 1.6) and 27 other tissues See more
    Orthologs

    Genomic context

    See Cntf in Genome Data Viewer
    Location:
    19 A; 19 8.73 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (12763528..12765632, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (12838018..12840122, complement)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene olfactory receptor 1443 Neighboring gene kidney expressed gene 1 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene predicted readthrough transcript (NMD candidate), 44505 Neighboring gene zinc finger protein 91 Neighboring gene leupaxin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough Gm44505

    Readthrough gene: Gm44505, Included gene: Zfp91

    Homology

    Clone Names

    • MGC41235

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ciliary neurotrophic factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ciliary neurotrophic factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-6 receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
     
    astrocyte activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    astrocyte activation ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    ciliary neurotrophic factor-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ciliary neurotrophic factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    membrane hyperpolarization ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    muscle organ morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of photoreceptor cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    neuron development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of axon extension involved in regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of axon regeneration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of axon regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tyrosine phosphorylation of STAT protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of tyrosine phosphorylation of STAT protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of resting membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of retinal cell programmed cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane bounded cell projection cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ciliary neurotrophic factor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_170786.2NP_740756.1  ciliary neurotrophic factor

      See identical proteins and their annotated locations for NP_740756.1

      Status: REVIEWED

      Source sequence(s)
      BC027539, BQ033243, W08735
      Consensus CDS
      CCDS29637.1
      UniProtKB/Swiss-Prot
      P51642
      UniProtKB/TrEMBL
      Q544D1
      Related
      ENSMUSP00000108555.1, OTTMUSP00000029848, ENSMUST00000112933.1, OTTMUST00000061010
      Conserved Domains (1) summary
      pfam01110
      Location:1182
      CNTF; Ciliary neurotrophic factor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      12763528..12765632 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_053007.2: Suppressed sequence

      Description
      NM_053007.2: This RefSeq was permanently suppressed because it actually represents the Zfp91-Cntf readthrough transcript, and not just Cntf.
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