U.S. flag

An official website of the United States government


Send to:

Choose Destination

Zfp91 zinc finger protein 91 [ Mus musculus (house mouse) ]

Gene ID: 109910, updated on 12-May-2024


Official Symbol
Zfp91provided by MGI
Official Full Name
zinc finger protein 91provided by MGI
Primary source
See related
Ensembl:ENSMUSG00000024695 AllianceGenome:MGI:104854
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pzf; Zfp-91; 9130014I08Rik; A530054C17Rik
The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. The homologous human protein has been shown to function as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. A read-through transcript variant composed of Zfp91 and the downstream Cntf gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of Zfp91 and Cntf has been observed in both human and mouse. A Zfp91-related pseudogene has also been identified on chromosome 17. [provided by RefSeq, Oct 2010]
Ubiquitous expression in testis adult (RPKM 19.5), bladder adult (RPKM 15.2) and 28 other tissues See more
Try the new Gene table
Try the new Transcript table

Genomic context

See Zfp91 in Genome Data Viewer
19 A; 19 8.73 cM
Exon count:
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (12744303..12773487, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (12766939..12796123, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene kidney expressed gene 1 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_45598 Neighboring gene predicted readthrough transcript (NMD candidate), 44505 Neighboring gene ciliary neurotrophic factor Neighboring gene STARR-positive B cell enhancer ABC_E11024 Neighboring gene STARR-positive B cell enhancer ABC_E4268 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:12870708-12870906 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:12871167-12871368 Neighboring gene STARR-positive B cell enhancer ABC_E8742 Neighboring gene STARR-positive B cell enhancer ABC_E7636 Neighboring gene leupaxin Neighboring gene ribosomal protein lateral stalk subunit P1, retrotransposed Neighboring gene olfactory receptor family 5 subfamily B member 21

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a


GeneRIFs: Gene References Into Functions

What's a GeneRIF?



Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (1)  1 citation


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Readthrough Gm44505

Readthrough gene: Gm44505, Included gene: Cntf

Clone Names

  • MGC195907

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
enables transferase activity IEA
Inferred from Electronic Annotation
more info
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
Process Evidence Code Pubs
involved_in activation of NF-kappaB-inducing kinase activity ISO
Inferred from Sequence Orthology
more info
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
Component Evidence Code Pubs
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info

General protein information

Preferred Names
E3 ubiquitin-protein ligase ZFP91
RING-type E3 ubiquitin transferase ZFP91
penta Zf protein
zinc finger protein 91 homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053009.3NP_443735.2  E3 ubiquitin-protein ligase ZFP91

    See identical proteins and their annotated locations for NP_443735.2

    Status: REVIEWED

    Source sequence(s)
    AK147502, AK147560, BE947731, CJ113470
    Consensus CDS
    Q3TEQ3, Q3UH61, Q62509, Q62511, Q6P219, Q6PG06, Q8BPY3, Q8C2B4, Q8CDZ3
    ENSMUSP00000037971.9, ENSMUST00000038627.9
    Conserved Domains (3) summary
    ZF_C2H2; C2H2 Zn finger [structural motif]
    zf-H2C2_2; Zinc-finger double domain
    zf-C2H2_8; C2H2-type zinc ribbon

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000085.7 Reference GRCm39 C57BL/6J

    12744303..12773487 complement
    GenBank, FASTA, Sequence Viewer (Graphics)