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    LRRC38 leucine rich repeat containing 38 [ Homo sapiens (human) ]

    Gene ID: 126755, updated on 17-Jun-2024

    Summary

    Official Symbol
    LRRC38provided by HGNC
    Official Full Name
    leucine rich repeat containing 38provided by HGNC
    Primary source
    HGNC:HGNC:27005
    See related
    Ensembl:ENSG00000162494 MIM:615212; AllianceGenome:HGNC:27005
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables potassium channel activator activity and transmembrane transporter binding activity. Involved in positive regulation of voltage-gated potassium channel activity and potassium ion transmembrane transport. Part of voltage-gated potassium channel complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in adrenal (RPKM 10.5) and prostate (RPKM 0.5) See more
    Orthologs
    NEW
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    Genomic context

    See LRRC38 in Genome Data Viewer
    Location:
    1p36.21
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (13474973..13514003, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (12916882..12955917, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (13801441..13840498, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PRAME family member 17 Neighboring gene PRAME family member 20 Neighboring gene uncharacterized LOC102724856 Neighboring gene uncharacterized LOC107984918 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:13848024-13849223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 214 Neighboring gene bromodomain and WD repeat domain containing 1 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:13910230-13910768 Neighboring gene podoplanin

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    General protein information

    Preferred Names
    leucine-rich repeat-containing protein 38
    Names
    BK channel auxiliary gamma subunit LRRC38
    BK channel auxilliary gamma subunit LRRC38

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010847.2NP_001010847.1  leucine-rich repeat-containing protein 38 precursor

      See identical proteins and their annotated locations for NP_001010847.1

      Status: VALIDATED

      Source sequence(s)
      AC243961, AL354712, BC016048
      Consensus CDS
      CCDS53269.1
      UniProtKB/Swiss-Prot
      Q5VT99, Q96B32
      Related
      ENSP00000365253.3, ENST00000376085.4
      Conserved Domains (6) summary
      smart00013
      Location:2758
      LRRNT; Leucine rich repeat N-terminal domain
      cd00116
      Location:45165
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:5881
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:3856
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:58116
      LRR_8; Leucine rich repeat
      cl15307
      Location:186237
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      13474973..13514003 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444690.1XP_047300646.1  leucine-rich repeat-containing protein 38 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      12916882..12955917 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334251.1XP_054190226.1  leucine-rich repeat-containing protein 38 isoform X1