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    Ccnk cyclin K [ Mus musculus (house mouse) ]

    Gene ID: 12454, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ccnkprovided by MGI
    Official Full Name
    cyclin Kprovided by MGI
    Primary source
    MGI:MGI:1276106
    See related
    Ensembl:ENSMUSG00000021258
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CPR4; CycK; AW123198; AW413594
    Expression
    Biased expression in testis adult (RPKM 101.3), limb E14.5 (RPKM 9.5) and 7 other tissues See more
    Orthologs

    Genomic context

    See Ccnk in Genome Data Viewer
    Location:
    12 F1; 12 59.23 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (108179465..108203359)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (109417948..109441569)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene B cell leukemia/lymphoma 11B Neighboring gene SET domain containing 3 Neighboring gene coiled-coil domain containing 85C Neighboring gene hedgehog interacting protein-like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation by host of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of DNA-templated transcription, elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cyclin K-CDK12 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin K-CDK13 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin/CDK positive transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009832.2NP_033962.2  cyclin-K

      See identical proteins and their annotated locations for NP_033962.2

      Status: VALIDATED

      Source sequence(s)
      AK146711, CA984404
      Consensus CDS
      CCDS49165.1
      UniProtKB/TrEMBL
      Q3U3M5
      Related
      ENSMUSP00000152784.1, ENSMUST00000221167.1
      Conserved Domains (1) summary
      cd00043
      Location:50148
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      108179465..108203359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515443.3XP_006515506.1  cyclin-K isoform X1

      See identical proteins and their annotated locations for XP_006515506.1

      UniProtKB/TrEMBL
      Q3U3M5
      Conserved Domains (1) summary
      cd00043
      Location:50148
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    2. XM_006515444.3XP_006515507.1  cyclin-K isoform X1

      See identical proteins and their annotated locations for XP_006515507.1

      UniProtKB/TrEMBL
      Q3U3M5
      Conserved Domains (1) summary
      cd00043
      Location:50148
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    3. XM_006515445.2XP_006515508.1  cyclin-K isoform X1

      See identical proteins and their annotated locations for XP_006515508.1

      UniProtKB/TrEMBL
      Q3U3M5
      Related
      ENSMUSP00000098616.4, ENSMUST00000101055.4
      Conserved Domains (1) summary
      cd00043
      Location:50148
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
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