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    Ccnk cyclin K [ Mus musculus (house mouse) ]

    Gene ID: 12454, updated on 12-Feb-2024

    Summary

    Official Symbol
    Ccnkprovided by MGI
    Official Full Name
    cyclin Kprovided by MGI
    Primary source
    MGI:MGI:1276106
    See related
    Ensembl:ENSMUSG00000021258 AllianceGenome:MGI:1276106
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CPR4; CycK
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity; protein kinase binding activity; and protein serine/threonine kinase activity. Acts upstream of or within in utero embryonic development and negative regulation of stem cell differentiation. Predicted to be located in nucleoplasm. Predicted to be part of cyclin K-CDK12 complex; cyclin K-CDK13 complex; and cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; olfactory epithelium; and retina nuclear layer. Orthologous to human CCNK (cyclin K). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 101.3), limb E14.5 (RPKM 9.5) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Ccnk in Genome Data Viewer
    Location:
    12 F1; 12 59.23 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (108145543..108170252)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (108179308..108203359)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33341 Neighboring gene STARR-seq mESC enhancer starr_33229 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109157062-109157245 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109164383-109164658 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109166259-109166489 Neighboring gene STARR-seq mESC enhancer starr_33230 Neighboring gene B cell leukemia/lymphoma 11B Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109202967-109203154 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109231387-109231540 Neighboring gene STARR-seq mESC enhancer starr_33235 Neighboring gene SET domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E743 Neighboring gene coiled-coil domain containing 85C Neighboring gene STARR-positive B cell enhancer mm9_chr12:109513689-109513989 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109514813-109514922 Neighboring gene STARR-positive B cell enhancer mm9_chr12:109572195-109572495 Neighboring gene hedgehog interacting protein-like 1 Neighboring gene cytochrome P450, family 46, subfamily a, polypeptide 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    part_of cyclin K-CDK12 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cyclin K-CDK13 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cyclin/CDK positive transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001421681.1NP_001408610.1  cyclin-K

      Status: VALIDATED

      Source sequence(s)
      AC152059
      UniProtKB/Swiss-Prot
      E9QKT7, O88874, Q8R068
      UniProtKB/TrEMBL
      Q3U3M5
    2. NM_001421682.1NP_001408611.1  cyclin-K

      Status: VALIDATED

      Source sequence(s)
      AC152059
      UniProtKB/Swiss-Prot
      E9QKT7, O88874, Q8R068
      UniProtKB/TrEMBL
      Q3U3M5
    3. NM_001421683.1NP_001408612.1  cyclin-K

      Status: VALIDATED

      Source sequence(s)
      AC152059
      UniProtKB/Swiss-Prot
      E9QKT7, O88874, Q8R068
      UniProtKB/TrEMBL
      Q3U3M5
    4. NM_009832.3NP_033962.2  cyclin-K

      See identical proteins and their annotated locations for NP_033962.2

      Status: VALIDATED

      Source sequence(s)
      AC152059
      Consensus CDS
      CCDS49165.1
      UniProtKB/Swiss-Prot
      E9QKT7, O88874, Q8R068
      UniProtKB/TrEMBL
      Q3U3M5
      Related
      ENSMUSP00000152784.2, ENSMUST00000221167.2
      Conserved Domains (1) summary
      COG5333
      Location:25217
      CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      108145543..108170252
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)