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CCNK cyclin K [ Homo sapiens (human) ]

Gene ID: 8812, updated on 6-Jan-2019

Summary

Official Symbol
CCNKprovided by HGNC
Official Full Name
cyclin Kprovided by HGNC
Primary source
HGNC:HGNC:1596
See related
Ensembl:ENSG00000090061 MIM:603544
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPR4; IDDHDF
Summary
The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 33.7), testis (RPKM 31.2) and 25 other tissues See more
Orthologs

Genomic context

See CCNK in Genome Data Viewer
Location:
14q32.2
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (99481402..99511515)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (99947695..99977852)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370660 Neighboring gene SET domain containing 3, actin histidine methyltransferase Neighboring gene RNA, U6 small nuclear 91, pseudogene Neighboring gene coiled-coil domain containing 85C Neighboring gene uncharacterized LOC105370661 Neighboring gene HNF4 motif-containing MPRA enhancer 184

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef induces cyclin K interaction with CDK9, which contributes to inhibit CDK9 nuclear translocation PubMed
nef Cyclin K physically interacts with HIV-1 Nef. Box 1 domain (residues 1-151) of cyclin K are necessary for its inhibitory activity on LTR-driven gene expression and virus production in a Nef-dependent manner PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9113

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation by host of viral genome replication IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell cycle arrest IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of DNA-templated transcription, elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cyclin-dependent protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
transcription elongation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cyclin K-CDK12 complex IPI
Inferred from Physical Interaction
more info
PubMed 
cyclin K-CDK13 complex IPI
Inferred from Physical Interaction
more info
PubMed 
cyclin/CDK positive transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099402.1NP_001092872.1  cyclin-K

    See identical proteins and their annotated locations for NP_001092872.1

    Status: REVIEWED

    Source sequence(s)
    BG503760, BM505592, BQ432222, BX247958
    Consensus CDS
    CCDS45160.1
    UniProtKB/Swiss-Prot
    O75909
    UniProtKB/TrEMBL
    A0A024R6K1
    Related
    ENSP00000374529.5, ENST00000389879.9
    Conserved Domains (1) summary
    cl28538
    Location:25217
    CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    99481402..99511515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268154.4XP_005268211.1  cyclin-K isoform X1

    See identical proteins and their annotated locations for XP_005268211.1

    UniProtKB/Swiss-Prot
    O75909
    UniProtKB/TrEMBL
    A0A024R6K1
    Conserved Domains (1) summary
    cl28538
    Location:25217
    CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]
  2. XM_011537275.2XP_011535577.1  cyclin-K isoform X1

    See identical proteins and their annotated locations for XP_011535577.1

    UniProtKB/Swiss-Prot
    O75909
    UniProtKB/TrEMBL
    A0A024R6K1
    Conserved Domains (1) summary
    cl28538
    Location:25217
    CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_003858.3: Suppressed sequence

    Description
    NM_003858.3: This RefSeq was permanently suppressed because it represents a poorly supported variant with non-consensus splice sites.
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