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    Cbl Casitas B-lineage lymphoma [ Mus musculus (house mouse) ]

    Gene ID: 12402, updated on 19-Feb-2019

    Summary

    Official Symbol
    Cblprovided by MGI
    Official Full Name
    Casitas B-lineage lymphomaprovided by MGI
    Primary source
    MGI:MGI:88279
    See related
    Ensembl:ENSMUSG00000034342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    cbl; Cbl-2; c-Cbl; 4732447J05Rik
    Expression
    Broad expression in thymus adult (RPKM 39.9), testis adult (RPKM 11.0) and 23 other tissues See more
    Orthologs

    Genomic context

    See Cbl in Genome Data Viewer
    Location:
    9 A5.1-A5.2; 9 24.72 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (44145040..44234046, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (43957345..44042129, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene 10687 Neighboring gene melanoma cell adhesion molecule Neighboring gene coiled-coil domain containing 153 Neighboring gene PDZ domain containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SH3 domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    ephrin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ephrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol 3-kinase regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to epidermal growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epidermal growth factor-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of Rap protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of platelet-derived growth factor receptor-alpha signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of signaling IEA
    Inferred from Electronic Annotation
    more info
     
    response to antibiotic ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cilium ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with flotillin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase CBL
    Names
    RING-type E3 ubiquitin transferase CBL
    casitas B-lineage lymphoma proto-oncogene
    proto-oncogene c-CBL
    signal transduction protein CBL
    NP_031645.2
    XP_006510026.1
    XP_017168604.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007619.2NP_031645.2  E3 ubiquitin-protein ligase CBL

      See identical proteins and their annotated locations for NP_031645.2

      Status: VALIDATED

      Source sequence(s)
      AC148328, AK029826, AK085140
      Consensus CDS
      CCDS40598.1
      UniProtKB/Swiss-Prot
      P22682
      Related
      ENSMUSP00000146244.1, ENSMUST00000206720.1
      Conserved Domains (5) summary
      cd09920
      Location:254350
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:379421
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14393
      Location:864903
      UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
      pfam02262
      Location:52173
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:177260
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      44145040..44234046 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313115.1XP_017168604.1  E3 ubiquitin-protein ligase CBL isoform X2

    2. XM_006509963.3XP_006510026.1  E3 ubiquitin-protein ligase CBL isoform X1

      UniProtKB/TrEMBL
      A0A0X1KG61
      Related
      ENSMUSP00000041902.7, ENSMUST00000037644.7
      Conserved Domains (5) summary
      cd09920
      Location:254350
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:379421
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14393
      Location:820859
      UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
      pfam02262
      Location:52173
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:177260
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
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