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    Capn7 calpain 7 [ Mus musculus (house mouse) ]

    Gene ID: 12339, updated on 26-Sep-2022

    Summary

    Official Symbol
    Capn7provided by MGI
    Official Full Name
    calpain 7provided by MGI
    Primary source
    MGI:MGI:1338030
    See related
    Ensembl:ENSMUSG00000021893 AllianceGenome:MGI:1338030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PalBH
    Summary
    Predicted to enable MIT domain binding activity and endopeptidase activity. Involved in proteolysis. Predicted to be located in centrosome and cytosol. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Orthologous to human CAPN7 (calpain 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 22.2), CNS E14 (RPKM 19.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Capn7 in Genome Data Viewer
    Location:
    14; 14 B
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31058582..31093944)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31336622..31371987)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene Brca1 associated protein 1 Neighboring gene dynein, axonemal, heavy chain 1 Neighboring gene predicted gene, 35823 Neighboring gene SH3-domain binding protein 5 (BTK-associated) Neighboring gene predicted gene, 35907 Neighboring gene PRELI domain-containing protein 2 pseudogene Neighboring gene methyltransferase like 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MIT domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in self proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    calpain-7
    Names
    palB homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360187.1NP_001347116.1  calpain-7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AB028640, BB855684, BE988205, BF462849, BY143496
      Conserved Domains (3) summary
      smart00720
      Location:643766
      calpain_III; calpain_III domain
      cd00044
      Location:170494
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cl00299
      Location:41113
      MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    2. NM_009796.3NP_033926.1  calpain-7 isoform 1

      See identical proteins and their annotated locations for NP_033926.1

      Status: VALIDATED

      Source sequence(s)
      AB028640, BB855684, BE988205, BF462849
      Consensus CDS
      CCDS26911.1
      UniProtKB/Swiss-Prot
      Q9R1S8, Q9Z0P9
      UniProtKB/TrEMBL
      A0A8C6IDF5
      Related
      ENSMUSP00000022451.8, ENSMUST00000022451.14
      Conserved Domains (4) summary
      smart00720
      Location:687810
      calpain_III; calpain_III domain
      cd00044
      Location:214538
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cd02681
      Location:576
      MIT_calpain7_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear.
      cl00299
      Location:85157
      MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      31058582..31093944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158431.1XP_036014324.1  calpain-7 isoform X2

      Conserved Domains (4) summary
      smart00720
      Location:593716
      calpain_III; calpain_III domain
      cd00044
      Location:214538
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cd02681
      Location:576
      MIT_calpain7_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear.
      cl00299
      Location:85157
      MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    2. XM_036158430.1XP_036014323.1  calpain-7 isoform X1

      Conserved Domains (2) summary
      smart00720
      Location:522645
      calpain_III; calpain_III domain
      cd00044
      Location:49373
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    3. XM_006518502.4XP_006518565.1  calpain-7 isoform X1

      Conserved Domains (2) summary
      smart00720
      Location:522645
      calpain_III; calpain_III domain
      cd00044
      Location:49373
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    4. XM_030247631.2XP_030103491.1  calpain-7 isoform X1

      Conserved Domains (2) summary
      smart00720
      Location:522645
      calpain_III; calpain_III domain
      cd00044
      Location:49373
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

    RNA

    1. XR_003950823.2 RNA Sequence

      Related
      ENSMUST00000143472.8
    2. XR_001781094.3 RNA Sequence