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CAPN7 calpain 7 [ Homo sapiens (human) ]

Gene ID: 23473, updated on 5-Aug-2018

Summary

Official Symbol
CAPN7provided by HGNC
Official Full Name
calpain 7provided by HGNC
Primary source
HGNC:HGNC:1484
See related
Ensembl:ENSG00000131375 MIM:606400; Vega:OTTHUMG00000129863
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PALBH; CALPAIN7
Summary
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 16.5), ovary (RPKM 11.2) and 25 other tissues See more
Orthologs

Genomic context

See CAPN7 in Genome Data Viewer
Location:
3p25.1
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (15206226..15252916)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (15247733..15294423)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein S3a pseudogene 53 Neighboring gene collagen type VI alpha 4 pseudogene 1 Neighboring gene SH3BP5 antisense RNA 1 Neighboring gene SH3 domain binding protein 5 Neighboring gene RNA, U6 small nuclear 454, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Degradation of the extracellular matrix, organism-specific biosystem (from REACTOME)
    Degradation of the extracellular matrix, organism-specific biosystemMatrix metalloproteinases (MMPs), previously referred to as matrixins because of their role in degradation of the extracellular matrix (ECM), are zinc and calcium dependent proteases belonging to the...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
  • Integrin-mediated Cell Adhesion, organism-specific biosystem (from WikiPathways)
    Integrin-mediated Cell Adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36423

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MIT domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of epithelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
self proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calpain-7
Names
calpain like protease
homolog of Aspergillus Nidulans PALB
palB homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014296.2NP_055111.1  calpain-7

    See identical proteins and their annotated locations for NP_055111.1

    Status: REVIEWED

    Source sequence(s)
    AB028639, BC056202, BI464220, BM974327, BX502535
    Consensus CDS
    CCDS2624.1
    UniProtKB/Swiss-Prot
    Q9Y6W3
    UniProtKB/TrEMBL
    Q7Z479
    Related
    ENSP00000253693.2, OTTHUMP00000160302, ENST00000253693.6, OTTHUMT00000252105
    Conserved Domains (4) summary
    smart00720
    Location:687810
    calpain_III; calpain_III domain
    cd00044
    Location:214538
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    cd02681
    Location:576
    MIT_calpain7_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear.
    cl00299
    Location:85159
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    15206226..15252916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533557.3XP_011531859.1  calpain-7 isoform X4

    Conserved Domains (4) summary
    smart00720
    Location:609732
    calpain_III; calpain_III domain
    cd00044
    Location:214554
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    cd02681
    Location:576
    MIT_calpain7_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear.
    cl00299
    Location:85159
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
  2. XM_017006044.2XP_016861533.1  calpain-7 isoform X5

  3. XM_011533556.2XP_011531858.1  calpain-7 isoform X2

    Conserved Domains (3) summary
    smart00720
    Location:659782
    calpain_III; calpain_III domain
    cd00044
    Location:170510
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    cl00299
    Location:41115
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
  4. XM_017006043.1XP_016861532.1  calpain-7 isoform X3

  5. XM_017006045.2XP_016861534.1  calpain-7 isoform X6

  6. XM_011533555.3XP_011531857.1  calpain-7 isoform X1

    Conserved Domains (4) summary
    smart00720
    Location:703826
    calpain_III; calpain_III domain
    cd00044
    Location:214554
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    cd02681
    Location:576
    MIT_calpain7_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear.
    cl00299
    Location:85159
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

RNA

  1. XR_940399.3 RNA Sequence

  2. XR_001740073.2 RNA Sequence

  3. XR_001740077.2 RNA Sequence

  4. XR_001740072.2 RNA Sequence

  5. XR_001740074.2 RNA Sequence

  6. XR_001740075.2 RNA Sequence

  7. XR_001740076.2 RNA Sequence

  8. XR_001740078.2 RNA Sequence

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