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    Adam10 a disintegrin and metallopeptidase domain 10 [ Mus musculus (house mouse) ]

    Gene ID: 11487, updated on 14-Sep-2021

    Summary

    Official Symbol
    Adam10provided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 10provided by MGI
    Primary source
    MGI:MGI:109548
    See related
    Ensembl:ENSMUSG00000054693
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    kuz; MADM; kuzb; kuzbanian; 1700031C13Rik
    Summary
    This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that is involved in the proteolytic release of membrane-bound proteins in a process called ectodomain shedding. Mice lacking the encoded protein die in utero with multiple defects of the developing central nervous system, somites, and cardiovascular system. [provided by RefSeq, May 2016]
    Expression
    Ubiquitous expression in liver E14 (RPKM 28.0), liver E14.5 (RPKM 23.2) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Adam10 in Genome Data Viewer
    Location:
    9 D; 9 39.53 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (70586133..70687511)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (70678944..70780229)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (70526808..70628036)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene SAFB-like, transcription modulator Neighboring gene MINDY lysine 48 deubiquitinase 2 Neighboring gene predicted gene, 31872 Neighboring gene cytochrome c, pseudogene 1 Neighboring gene VISTA enhancer mm190 Neighboring gene lipase, hepatic Neighboring gene ribosomal RNA processing 7 homolog A pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH2 domain binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metalloendopeptidase activity TAS
    Traceable Author Statement
    more info
     
    enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    enables metallopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metallopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Notch receptor processing NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adherens junction organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in amyloid precursor protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cochlea development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in constitutive protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in membrane protein ectodomain proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in membrane protein ectodomain proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monocyte activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleocytoplasmic transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in pore complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pore complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in postsynapse organization EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in postsynapse organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in toxin transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi-associated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of pore complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of pore complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in tetraspanin-enriched microdomain ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 10
    Names
    a disintegrin and metalloprotease domain (ADAM) 10
    kuzbanian protein homolog
    mammalian disintegrin-metalloprotease
    NP_031425.2
    XP_030099887.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007399.4NP_031425.2  disintegrin and metalloproteinase domain-containing protein 10 preproprotein

      See identical proteins and their annotated locations for NP_031425.2

      Status: REVIEWED

      Source sequence(s)
      AC160636, AK031857, BC057346, BC066207, BE654195, BY205591
      Consensus CDS
      CCDS23323.1
      UniProtKB/Swiss-Prot
      O35598
      UniProtKB/TrEMBL
      Q6NZC0
      Related
      ENSMUSP00000063839.7, ENSMUST00000067880.13
      Conserved Domains (4) summary
      smart00050
      Location:467546
      DISIN; Homologues of snake disintegrins
      cd04270
      Location:221460
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam01562
      Location:46146
      Pep_M12B_propep; Reprolysin family propeptide
      pfam13574
      Location:241445
      Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      70586133..70687511
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244027.2XP_030099887.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X1

      Conserved Domains (2) summary
      smart00050
      Location:393472
      DISIN; Homologues of snake disintegrins
      cd04270
      Location:147386
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
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