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    Adam10 a disintegrin and metallopeptidase domain 10 [ Mus musculus (house mouse) ]

    Gene ID: 11487, updated on 19-Mar-2019

    Summary

    Official Symbol
    Adam10provided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 10provided by MGI
    Primary source
    MGI:MGI:109548
    See related
    Ensembl:ENSMUSG00000054693
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    kuz; MADM; kuzbanian; 1700031C13Rik
    Summary
    This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that is involved in the proteolytic release of membrane-bound proteins in a process called ectodomain shedding. Mice lacking the encoded protein die in utero with multiple defects of the developing central nervous system, somites, and cardiovascular system. [provided by RefSeq, May 2016]
    Expression
    Ubiquitous expression in liver E14 (RPKM 28.0), liver E14.5 (RPKM 23.2) and 27 other tissues See more
    Orthologs

    Genomic context

    See Adam10 in Genome Data Viewer
    Location:
    9 D; 9 39.53 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (70678918..70780229)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (70526808..70628036)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene MINDY lysine 48 deubiquitinase 2 Neighboring gene predicted gene, 31872 Neighboring gene cytochrome c, pseudogene 1 Neighboring gene lipase, hepatic Neighboring gene ribosomal RNA processing 7 homolog A pseudogene Neighboring gene predicted gene, 32017

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SH2 domain binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    metallopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metallopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    Notch receptor processing NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    PMA-inducible membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    constitutive protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    monocyte activation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleocytoplasmic transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of T cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    postsynapse organization EXP
    Inferred from Experiment
    more info
    PubMed 
    postsynapse organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neurotransmitter receptor localization to postsynaptic specialization membrane EXP
    Inferred from Experiment
    more info
    PubMed 
    regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    Golgi-associated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    collagen-containing extracellular matrix HDA PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space HDA PubMed 
    glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    glutamatergic synapse IC
    Inferred by Curator
    more info
    PubMed 
    glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    tetraspanin-enriched microdomain ISO
    Inferred from Sequence Orthology
    more info
     
    trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 10
    Names
    a disintegrin and metalloprotease domain (ADAM) 10
    kuzbanian protein homolog
    mammalian disintegrin-metalloprotease
    NP_031425.2
    XP_011240959.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007399.4NP_031425.2  disintegrin and metalloproteinase domain-containing protein 10 preproprotein

      See identical proteins and their annotated locations for NP_031425.2

      Status: REVIEWED

      Source sequence(s)
      AC160636, AK031857, BC057346, BC066207, BE654195, BY205591
      Consensus CDS
      CCDS23323.1
      UniProtKB/Swiss-Prot
      O35598
      UniProtKB/TrEMBL
      Q6NZC0
      Related
      ENSMUSP00000063839.6, ENSMUST00000067880.12
      Conserved Domains (4) summary
      smart00050
      Location:467546
      DISIN; Homologues of snake disintegrins
      cd04270
      Location:221460
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam01562
      Location:46146
      Pep_M12B_propep; Reprolysin family propeptide
      pfam13574
      Location:241445
      Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      70678918..70780229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242657.2XP_011240959.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X1

      Conserved Domains (4) summary
      smart00050
      Location:471550
      DISIN; Homologues of snake disintegrins
      cd04270
      Location:225464
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam01562
      Location:50150
      Pep_M12B_propep; Reprolysin family propeptide
      pfam13574
      Location:245449
      Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like
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