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    Tars threonyl-tRNA synthetase [ Mus musculus (house mouse) ]

    Gene ID: 110960, updated on 2-Oct-2018

    Summary

    Official Symbol
    Tarsprovided by MGI
    Official Full Name
    threonyl-tRNA synthetaseprovided by MGI
    Primary source
    MGI:MGI:106314
    See related
    Ensembl:ENSMUSG00000022241
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ThrRS; D15Wsu59e
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 35.0), liver E14 (RPKM 27.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Tars in Genome Data Viewer
    Location:
    15 A1; 15 5.6 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (11383663..11399658, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (11313418..11329413, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12 Neighboring gene predicted gene, 34444 Neighboring gene predicted gene, 41271 Neighboring gene predicted gene, 41272

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    threonine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    threonine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    threonine-tRNA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
     
    threonyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    threonyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    threonine--tRNA ligase, cytoplasmic
    Names
    threonyl-tRNA synthetase, cytoplasmic
    NP_149065.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033074.3NP_149065.2  threonine--tRNA ligase, cytoplasmic

      See identical proteins and their annotated locations for NP_149065.2

      Status: PROVISIONAL

      Source sequence(s)
      AK011146
      Consensus CDS
      CCDS27385.1
      UniProtKB/Swiss-Prot
      Q9D0R2
      Related
      ENSMUSP00000022849.5, ENSMUST00000022849.6
      Conserved Domains (5) summary
      cd01667
      Location:82143
      TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
      PLN02908
      Location:50715
      PLN02908; threonyl-tRNA synthetase
      smart00863
      Location:249296
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
      cd00771
      Location:320617
      ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00860
      Location:617708
      ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      11383663..11399658 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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