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TARS1 threonyl-tRNA synthetase 1 [ Homo sapiens (human) ]

Gene ID: 6897, updated on 8-Jul-2021

Summary

Official Symbol
TARS1provided by HGNC
Official Full Name
threonyl-tRNA synthetase 1provided by HGNC
Primary source
HGNC:HGNC:11572
See related
Ensembl:ENSG00000113407 MIM:187790
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TARS; TTD7; ThrRS
Summary
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 23.8), esophagus (RPKM 20.5) and 25 other tissues See more
Orthologs
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Genomic context

See TARS1 in Genome Data Viewer
Location:
5p13.3
Exon count:
22
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (33440696..33468091)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (33440802..33468196)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene translation machinery-associated protein 7 pseudogene Neighboring gene TARS1 divergent transcript Neighboring gene TOMM40 pseudogene 3 Neighboring gene uncharacterized LOC105374717

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
matrix gag HIV-1 MA is identified to have a physical interaction with threonyl-tRNA synthetase (TARS) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9344

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables threonine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables threonine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables threonine-tRNA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in threonyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in threonyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in threonyl-tRNA aminoacylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 

General protein information

Preferred Names
threonine--tRNA ligase 1, cytoplasmic
Names
threonine tRNA ligase 1, cytoplasmic
threonine--tRNA ligase, cytoplasmic
threonyl-tRNA synthetase, cytoplasmic
NP_001245366.1
NP_001245367.1
NP_689508.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258437.1NP_001245366.1  threonine--tRNA ligase 1, cytoplasmic isoform 1

    See identical proteins and their annotated locations for NP_001245366.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC025441, AK292346, BG183397
    Consensus CDS
    CCDS3899.1
    UniProtKB/Swiss-Prot
    P26639
    Related
    ENSP00000424387.1, ENST00000502553.5
    Conserved Domains (1) summary
    PLN02908
    Location:44716
    PLN02908; threonyl-tRNA synthetase
  2. NM_001258438.2NP_001245367.1  threonine--tRNA ligase 1, cytoplasmic isoform 2

    See identical proteins and their annotated locations for NP_001245367.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is longer compared to isoform 1.
    Source sequence(s)
    AC025441, AC034231, AK293620
    Consensus CDS
    CCDS58943.1
    UniProtKB/Swiss-Prot
    P26639
    Related
    ENSP00000387710.2, ENST00000455217.6
    Conserved Domains (1) summary
    PLN02908
    Location:44749
    PLN02908; threonyl-tRNA synthetase
  3. NM_152295.5NP_689508.3  threonine--tRNA ligase 1, cytoplasmic isoform 1

    See identical proteins and their annotated locations for NP_689508.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the smaller protein (isoform 1). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC025441, AW246273, BC000517
    Consensus CDS
    CCDS3899.1
    UniProtKB/Swiss-Prot
    P26639
    Related
    ENSP00000265112.3, ENST00000265112.8
    Conserved Domains (1) summary
    PLN02908
    Location:44716
    PLN02908; threonyl-tRNA synthetase

RNA

  1. NR_047676.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC025441, AC034231, AK308342
  2. NR_047677.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon and uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC025441, AC034231, AK296783, KF510921
    Related
    ENST00000507716.5
  3. NR_047678.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC025441, AK095852
    Related
    ENST00000508361.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    33440696..33468091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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