U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    PRG3 proteoglycan 3, pro eosinophil major basic protein 2 [ Homo sapiens (human) ]

    Gene ID: 10394, updated on 5-Mar-2024

    Summary

    Official Symbol
    PRG3provided by HGNC
    Official Full Name
    proteoglycan 3, pro eosinophil major basic protein 2provided by HGNC
    Primary source
    HGNC:HGNC:9363
    See related
    Ensembl:ENSG00000156575 MIM:606814; AllianceGenome:HGNC:9363
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MBP2; MBPH
    Summary
    An extracellular matrix structural constituent conferring compression resistance. Involved in several processes, including granulocyte activation; histamine biosynthetic process; and regulation of gene expression. Located in collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward bone marrow (RPKM 15.2) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PRG3 in Genome Data Viewer
    Location:
    11q12.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (57376769..57381150, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (57326801..57331179, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57144242..57148623, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3345 Neighboring gene structure specific recognition protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4716 Neighboring gene purinergic receptor P2X 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:57117303-57117802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:57132373-57132874 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:57136946-57138145 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:57146812-57148011 Neighboring gene proteoglycan 2, pro eosinophil major basic protein Neighboring gene solute carrier family 43 member 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:57182050-57182550 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:57193011-57194210 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3346

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-Tat peptide interferes with polyamine uptake via competition for proteoglycan binding sites rather than a putative downstream transporter in human carcinoma cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC126662, MGC141971

    General protein information

    Preferred Names
    proteoglycan 3
    Names
    eosinophil major basic protein homolog
    prepro-MBPH
    prepro-major basic protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006093.4NP_006084.2  proteoglycan 3 precursor

      See identical proteins and their annotated locations for NP_006084.2

      Status: VALIDATED

      Source sequence(s)
      AF132209, AP000781, AY358930
      Consensus CDS
      CCDS7954.1
      UniProtKB/Swiss-Prot
      Q9Y2Y8
      Related
      ENSP00000287143.2, ENST00000287143.2
      Conserved Domains (1) summary
      cd03598
      Location:110225
      CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      57376769..57381150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      57326801..57331179 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)