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    Numa1 nuclear mitotic apparatus protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 101706, updated on 17-Jul-2021

    Summary

    Official Symbol
    Numa1provided by MGI
    Official Full Name
    nuclear mitotic apparatus protein 1provided by MGI
    Primary source
    MGI:MGI:2443665
    See related
    Ensembl:ENSMUSG00000066306
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nu; NuMA; AA764025; AL022610; AU014979; 6720401E04Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 20.3), ovary adult (RPKM 17.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Numa1 in Genome Data Viewer
    Location:
    7; 7 E2
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101583169..101664166)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101933977..102014959)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (109118357..109163473)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Neighboring gene transmembrane O-methyltransferase Neighboring gene leucine rich repeat containing 51 Neighboring gene MYST histone acetyltransferase 1 pseudogene Neighboring gene predicted gene, 39061 Neighboring gene interleukin 18 binding protein Neighboring gene ring finger protein 121 Neighboring gene Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough Neighboring gene Xrcc1 N-terminal domain containing 1 Neighboring gene transient receptor potential cation channel, subfamily C, member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables disordered domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables dynein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule minus-end binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in anastral spindle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in astral microtubule organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of mitotic spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
     
    involved_in establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of mitotic spindle orientation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lung epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
     
    involved_in microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chromosome separation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of intracellular transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic spindle elongation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to spindle pole body ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of spindle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of metaphase plate congression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
     
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex region ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cortical microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic microtubule bundle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lateral cell cortex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule bundle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule minus-end ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle astral microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle midzone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in spindle pole centrosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nuclear mitotic apparatus protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133947.3NP_598708.3  nuclear mitotic apparatus protein 1

      See identical proteins and their annotated locations for NP_598708.3

      Status: VALIDATED

      Source sequence(s)
      AK032693, BC049791
      Consensus CDS
      CCDS40046.1
      UniProtKB/Swiss-Prot
      E9Q7G0
      Related
      ENSMUSP00000081912.6, ENSMUST00000084852.13
      Conserved Domains (4) summary
      COG1196
      Location:11171713
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:5541323
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd22224
      Location:6151
      HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins
      cd22298
      Location:18521910
      NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      101583169..101664166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507177.4XP_006507240.1  nuclear mitotic apparatus protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006507240.1

      UniProtKB/Swiss-Prot
      E9Q7G0
      Conserved Domains (4) summary
      COG1196
      Location:11171713
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:5541323
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd22224
      Location:6151
      HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins
      cd22298
      Location:18521910
      NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
    2. XM_006507169.4XP_006507232.1  nuclear mitotic apparatus protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006507232.1

      Conserved Domains (1) summary
      TIGR02168
      Location:5541323
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    3. XM_036152543.1XP_036008436.1  nuclear mitotic apparatus protein 1 isoform X2

      Conserved Domains (4) summary
      COG1196
      Location:11171713
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:5541323
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd22224
      Location:6151
      HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins
      cd22298
      Location:18521910
      NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
    4. XM_006507174.3XP_006507237.1  nuclear mitotic apparatus protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006507237.1

      Conserved Domains (1) summary
      TIGR02168
      Location:5541323
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    5. XM_036152542.1XP_036008435.1  nuclear mitotic apparatus protein 1 isoform X2

      Conserved Domains (4) summary
      COG1196
      Location:11171713
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:5541323
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd22224
      Location:6151
      HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins
      cd22298
      Location:18521910
      NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
    6. XM_006507173.4XP_006507236.1  nuclear mitotic apparatus protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006507236.1

      Conserved Domains (1) summary
      TIGR02168
      Location:5541323
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    7. XM_006507172.5XP_006507235.1  nuclear mitotic apparatus protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006507235.1

      Conserved Domains (1) summary
      TIGR02168
      Location:5541323
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    8. XM_030241949.2XP_030097809.1  nuclear mitotic apparatus protein 1 isoform X3

      Conserved Domains (1) summary
      TIGR02168
      Location:5051274
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    9. XM_030241950.2XP_030097810.1  nuclear mitotic apparatus protein 1 isoform X4

      Conserved Domains (2) summary
      COG1196
      Location:10681664
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:5051274
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    10. XM_036152544.1XP_036008437.1  nuclear mitotic apparatus protein 1 isoform X5

      Conserved Domains (3) summary
      TIGR02168
      Location:4621231
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd22298
      Location:17741832
      NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
      cl41774
      Location:159
      HkD_SF; Hook domain-containing proteins superfamily
    11. XM_006507170.4XP_006507233.1  nuclear mitotic apparatus protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006507233.1

      Conserved Domains (1) summary
      TIGR02168
      Location:5541323
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    12. XM_036152541.1XP_036008434.1  nuclear mitotic apparatus protein 1 isoform X2

      Conserved Domains (4) summary
      COG1196
      Location:11171713
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:5541323
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd22224
      Location:6151
      HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins
      cd22298
      Location:18521910
      NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
    13. XM_006507175.4XP_006507238.1  nuclear mitotic apparatus protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006507238.1

      Conserved Domains (1) summary
      TIGR02168
      Location:5541323
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    14. XM_006507171.5XP_006507234.1  nuclear mitotic apparatus protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006507234.1

      Conserved Domains (1) summary
      TIGR02168
      Location:5541323
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    15. XM_036152540.1XP_036008433.1  nuclear mitotic apparatus protein 1 isoform X2

      Conserved Domains (4) summary
      COG1196
      Location:11171713
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:5541323
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd22224
      Location:6151
      HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins
      cd22298
      Location:18521910
      NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
    16. XM_030241948.2XP_030097808.1  nuclear mitotic apparatus protein 1 isoform X1

      Conserved Domains (1) summary
      TIGR02168
      Location:5541323
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
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