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    CELA3A chymotrypsin like elastase 3A [ Homo sapiens (human) ]

    Gene ID: 10136, updated on 5-Mar-2024

    Summary

    Official Symbol
    CELA3Aprovided by HGNC
    Official Full Name
    chymotrypsin like elastase 3Aprovided by HGNC
    Primary source
    HGNC:HGNC:15944
    See related
    Ensembl:ENSG00000142789 MIM:618693; AllianceGenome:HGNC:15944
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ELA3; ELA3A
    Summary
    Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward pancreas (RPKM 29060.2) See more
    Orthologs
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    Genomic context

    Location:
    1p36.12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (22001657..22012542)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (21825474..21836366)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (22328150..22339035)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chymotrypsin like elastase 3B Neighboring gene RNA, U6 small nuclear 1022, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 386, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 186, pseudogene Neighboring gene RNA, U6 small nuclear 776, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 345 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 392 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 393 Neighboring gene Sharpr-MPRA regulatory region 3950 Neighboring gene long intergenic non-protein coding RNA 1635 Neighboring gene long intergenic non-protein coding RNA 339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 347 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_5374 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 394 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:22379623-22380190 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:22380191-22380759 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:22387820-22388320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:22388321-22388821 Neighboring gene cell division cycle 42 Neighboring gene MPHOSPH6 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    chymotrypsin-like elastase family member 3A
    Names
    chymotrypsin like elastase family member 3A
    elastase 1
    elastase 3A, pancreatic
    elastase IIIA
    elastase-3A
    protease E
    NP_005738.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005747.5NP_005738.4  chymotrypsin-like elastase family member 3A preproprotein

      See identical proteins and their annotated locations for NP_005738.4

      Status: REVIEWED

      Source sequence(s)
      AK225620, AW583482, BC015103
      Consensus CDS
      CCDS220.1
      UniProtKB/Swiss-Prot
      B1AQ53, P09093, Q9BRW4
      UniProtKB/TrEMBL
      Q96QL8
      Related
      ENSP00000290122.3, ENST00000290122.8
      Conserved Domains (2) summary
      smart00020
      Location:28263
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:29266
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      22001657..22012542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      21825474..21836366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)