Format

Send to:

Choose Destination

CDC34 cell division cycle 34, ubiqiutin conjugating enzyme [ Homo sapiens (human) ]

Gene ID: 997, updated on 5-Jul-2020

Summary

Official Symbol
CDC34provided by HGNC
Official Full Name
cell division cycle 34, ubiqiutin conjugating enzymeprovided by HGNC
Primary source
HGNC:HGNC:1734
See related
Ensembl:ENSG00000099804 MIM:116948
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBC3; UBCH3; UBE2R1; E2-CDC34
Summary
The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 23.4), placenta (RPKM 14.2) and 25 other tissues See more
Orthologs

Genomic context

See CDC34 in Genome Data Viewer
Location:
19p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (531720..542088)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (531720..542087)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372232 Neighboring gene mucosal vascular addressin cell adhesion molecule 1 Neighboring gene tubulin polyglutamylase complex subunit 1 Neighboring gene granzyme M Neighboring gene CRISPRi-validated cis-regulatory element chr19.73

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif CUL5/RBX2/ELOB/ELOC/Vif/CBF-beta complex catalyzes polyubiquitin chain formation on A3G in the presence of ubiquitin E2 UBE2R1 (CDC34) or UBCH5b (UBE2D2) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
DNA replication initiation NAS
Non-traceable Author Statement
more info
PubMed 
G1/S transition of mitotic cell cycle NAS
Non-traceable Author Statement
more info
PubMed 
cellular protein modification process NAS
Non-traceable Author Statement
more info
PubMed 
cellular response to interferon-beta IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cAMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of inclusion body assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination NAS
Non-traceable Author Statement
more info
PubMed 
protein ubiquitination TAS
Traceable Author Statement
more info
 
response to growth factor IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 R1
Names
(E3-independent) E2 ubiquitin-conjugating enzyme R1
E2 ubiquitin-conjugating enzyme R1
cell division cycle 34 homolog
ubiquitin carrier protein
ubiquitin-conjugating enzyme E2-32 KDA complementing
ubiquitin-conjugating enzyme E2-CDC34
ubiquitin-protein ligase R1
NP_004350.1
XP_005259747.1
XP_006723015.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004359.2NP_004350.1  ubiquitin-conjugating enzyme E2 R1

    See identical proteins and their annotated locations for NP_004350.1

    Status: REVIEWED

    Source sequence(s)
    AC011531, AC011556
    Consensus CDS
    CCDS12030.1
    UniProtKB/Swiss-Prot
    P49427
    UniProtKB/TrEMBL
    A0A024R1Z1
    Related
    ENSP00000215574.2, ENST00000215574.9
    Conserved Domains (1) summary
    cd00195
    Location:11162
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    531720..542088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722952.2XP_006723015.1  ubiquitin-conjugating enzyme E2 R1 isoform X2

    Related
    ENSP00000475282.3, ENST00000586283.6
    Conserved Domains (2) summary
    COG5078
    Location:6162
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00195
    Location:11162
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  2. XM_005259690.3XP_005259747.1  ubiquitin-conjugating enzyme E2 R1 isoform X1

    Conserved Domains (2) summary
    COG5078
    Location:6162
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00195
    Location:11162
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
Support Center