U.S. flag

An official website of the United States government


Send to:

Choose Destination

HS3ST3B1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 [ Homo sapiens (human) ]

Gene ID: 9953, updated on 5-Mar-2024


Official Symbol
HS3ST3B1provided by HGNC
Official Full Name
heparan sulfate-glucosamine 3-sulfotransferase 3B1provided by HGNC
Primary source
See related
Ensembl:ENSG00000125430 MIM:604058; AllianceGenome:HGNC:5198
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
3OST3B1; 3-OST-3B; h3-OST-3B
The protein encoded by this gene is a type II integral membrane protein that belongs to the 3-O-sulfotransferases family. These proteins catalyze the addition of sulfate groups at the 3-OH position of glucosamine in heparan sulfate. The substrate specificity of individual members of the family is based on prior modification of the heparan sulfate chain, thus allowing different members of the family to generate binding sites for different proteins on the same heparan sulfate chain. Following treatment with a histone deacetylase inhibitor, expression of this gene is activated in a pancreatic cell line. The increased expression results in promotion of the epithelial-mesenchymal transition. In addition, the modification catalyzed by this protein allows herpes simplex virus membrane fusion and penetration. A very closely related homolog with an almost identical sulfotransferase domain maps less than 1 Mb away. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Broad expression in liver (RPKM 6.8), lymph node (RPKM 3.1) and 21 other tissues See more
Try the new Gene table
Try the new Transcript table

Genomic context

See HS3ST3B1 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (14301081..14349404)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (14207195..14255584)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (14204398..14252721)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11742 Neighboring gene cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 Neighboring gene distal CMT1A-REP Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47071 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:14109359-14109859 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:14139403-14139910 Neighboring gene CMT1A duplicated region transcript 15 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8208 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:14206998-14207498 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8209 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:14213102-14213622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:14213623-14214143 Neighboring gene NANOG hESC enhancer GRCh37_chr17:14226810-14227361 Neighboring gene uncharacterized protein MGC12916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:14256381-14257207 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8210 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:14276639-14277838 Neighboring gene uncharacterized LOC107985080 Neighboring gene NANOG hESC enhancer GRCh37_chr17:14462906-14463439 Neighboring gene uncharacterized LOC107984996

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


EBI GWAS Catalog

A genome-wide association study identifies protein quantitative trait loci (pQTLs).
EBI GWAS Catalog
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
EBI GWAS Catalog

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
heparan sulfate glucosamine 3-O-sulfotransferase 3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
heparan sulfate 3-O-sulfotransferase 3B1
heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006041.3NP_006032.1  heparan sulfate glucosamine 3-O-sulfotransferase 3B1

    See identical proteins and their annotated locations for NP_006032.1

    Status: REVIEWED

    Transcript Variant: This variant (1) represents the longer transcript. It encodes the protein.
    Source sequence(s)
    AC005224, AK023723, BC063301, BM968044, DA388077
    Consensus CDS
    B3KN58, D3DTS6, Q9Y662
    ENSP00000354213.2, ENST00000360954.3
    Conserved Domains (1) summary
    Sulfotransfer_1; Sulfotransferase domain


  1. NR_130138.2 RNA Sequence

    Status: REVIEWED

    Transcript Variant: This variant (2) uses an alternate 3' exon structure compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005224, AC022816, AK023723, BC063301, BM968044, DA388077

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025479.3XP_016880968.1  heparan sulfate glucosamine 3-O-sulfotransferase 3B1 isoform X1


Alternate T2T-CHM13v2.0


  1. NC_060941.1 Alternate T2T-CHM13v2.0

    GenBank, FASTA, Sequence Viewer (Graphics)