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G3BP2 G3BP stress granule assembly factor 2 [ Homo sapiens (human) ]

Gene ID: 9908, updated on 4-Oct-2020

Summary

Official Symbol
G3BP2provided by HGNC
Official Full Name
G3BP stress granule assembly factor 2provided by HGNC
Primary source
HGNC:HGNC:30291
See related
Ensembl:ENSG00000138757
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in brain (RPKM 45.6), thyroid (RPKM 35.2) and 25 other tissues See more
Orthologs

Genomic context

See G3BP2 in Genome Data Viewer
Location:
4q21.1
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (75642782..75724470, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (76567953..76649709, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene odontogenesis associated phosphoprotein Neighboring gene cytochrome c oxidase subunit 6C pseudogene 9 Neighboring gene cyclin dependent kinase like 2 Neighboring gene USO1 vesicle transport factor Neighboring gene uncharacterized LOC105377284 Neighboring gene RNA, U2 small nuclear 16, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with GTPase activating protein (SH3 domain) binding protein 2 (G3BP2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Vpr vpr HIV-1 Vpr upregulates G3BP2 in HeLa cells within 12 hours of exposure PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor signaling complex scaffold activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Ras protein signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
cytoplasmic sequestering of NF-kappaB NAS
Non-traceable Author Statement
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of stress granule assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein homooligomerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
stress granule assembly IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytoplasmic stress granule IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ras GTPase-activating protein-binding protein 2
Names
G3BP-2
GAP SH3 domain-binding protein 2
GTPase activating protein (SH3 domain) binding protein 2
Ras-GTPase activating protein SH3 domain-binding protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012297.5NP_036429.2  ras GTPase-activating protein-binding protein 2 isoform a

    See identical proteins and their annotated locations for NP_036429.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AB014560, AI913597, BM744299, DA094091
    Consensus CDS
    CCDS3571.1
    UniProtKB/Swiss-Prot
    Q9UN86
    UniProtKB/TrEMBL
    A0A024RDE5
    Related
    ENSP00000379069.3, ENST00000395719.7
    Conserved Domains (2) summary
    cd00780
    Location:7135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12464
    Location:326408
    RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
  2. NM_203504.3NP_987100.1  ras GTPase-activating protein-binding protein 2 isoform b

    See identical proteins and their annotated locations for NP_987100.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB014560, AI913597, BC011731, BM744299, DA385285
    Consensus CDS
    CCDS3572.1
    UniProtKB/Swiss-Prot
    Q9UN86
    UniProtKB/TrEMBL
    A0A024RDB2
    Related
    ENSP00000350518.3, ENST00000357854.7
    Conserved Domains (2) summary
    cd00780
    Location:7135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cl17169
    Location:293375
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. NM_203505.3NP_987101.1  ras GTPase-activating protein-binding protein 2 isoform a

    See identical proteins and their annotated locations for NP_987101.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AB014560, AF145284, AI913597, BM744299, DB241424
    Consensus CDS
    CCDS3571.1
    UniProtKB/Swiss-Prot
    Q9UN86
    UniProtKB/TrEMBL
    A0A024RDE5
    Related
    ENSP00000352738.4, ENST00000359707.8
    Conserved Domains (2) summary
    cd00780
    Location:7135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12464
    Location:326408
    RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    75642782..75724470 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263382.3XP_005263439.1  ras GTPase-activating protein-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005263439.1

    UniProtKB/Swiss-Prot
    Q9UN86
    UniProtKB/TrEMBL
    A0A024RDE5
    Conserved Domains (2) summary
    cd00780
    Location:7135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12464
    Location:326408
    RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
  2. XM_005263383.3XP_005263440.1  ras GTPase-activating protein-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005263440.1

    UniProtKB/Swiss-Prot
    Q9UN86
    UniProtKB/TrEMBL
    A0A024RDE5
    Conserved Domains (2) summary
    cd00780
    Location:7135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12464
    Location:326408
    RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
  3. XM_017008878.1XP_016864367.1  ras GTPase-activating protein-binding protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9UN86
    UniProtKB/TrEMBL
    A0A024RDB2
    Conserved Domains (2) summary
    cd00780
    Location:7135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cl17169
    Location:293375
    RRM_SF; RNA recognition motif (RRM) superfamily
  4. XM_017008876.1XP_016864365.1  ras GTPase-activating protein-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9UN86
    UniProtKB/TrEMBL
    A0A024RDE5
    Conserved Domains (2) summary
    cd00780
    Location:7135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12464
    Location:326408
    RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
  5. XM_024454294.1XP_024310062.1  ras GTPase-activating protein-binding protein 2 isoform X1

    Conserved Domains (2) summary
    cd00780
    Location:7135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12464
    Location:326408
    RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
  6. XM_017008879.1XP_016864368.1  ras GTPase-activating protein-binding protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9UN86
    UniProtKB/TrEMBL
    A0A024RDB2
    Conserved Domains (2) summary
    cd00780
    Location:7135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cl17169
    Location:293375
    RRM_SF; RNA recognition motif (RRM) superfamily
  7. XM_011532441.2XP_011530743.1  ras GTPase-activating protein-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011530743.1

    UniProtKB/Swiss-Prot
    Q9UN86
    UniProtKB/TrEMBL
    A0A024RDE5
    Conserved Domains (2) summary
    cd00780
    Location:7135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12464
    Location:326408
    RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
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