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RBM19 RNA binding motif protein 19 [ Homo sapiens (human) ]

Gene ID: 9904, updated on 7-Jul-2019

Summary

Official Symbol
RBM19provided by HGNC
Official Full Name
RNA binding motif protein 19provided by HGNC
Primary source
HGNC:HGNC:29098
See related
Ensembl:ENSG00000122965 MIM:616444
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Mrd1
Summary
This gene encodes a nucleolar protein that contains six RNA-binding motifs. The encoded protein may be involved in regulating ribosome biogenesis. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Apr 2009]
Expression
Ubiquitous expression in testis (RPKM 6.2), spleen (RPKM 5.9) and 25 other tissues See more
Orthologs

Genomic context

See RBM19 in Genome Data Viewer
Location:
12q24.13-q24.21
Exon count:
27
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (113816740..113966371, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (114254543..114404176, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1234 Neighboring gene dynein light chain LC8-type 1 pseudogene 4 Neighboring gene VISTA enhancer hs1673 Neighboring gene tRNA-Glu (anticodon CTC) 16-1 Neighboring gene uncharacterized LOC105369993 Neighboring gene CRE2 enhancer downstream of TBX5 Neighboring gene uncharacterized LOC105369994

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of RNA binding motif protein 19 (RBM19) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0682, DKFZp586F1023

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
mRNA cis splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
chromosome IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane HDA PubMed 
nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable RNA-binding protein 19

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146698.2NP_001140170.1  probable RNA-binding protein 19

    See identical proteins and their annotated locations for NP_001140170.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AA594568, AC090669, AK291444, AL117547, BC004289, DB096676
    Consensus CDS
    CCDS9172.1
    UniProtKB/Swiss-Prot
    Q9Y4C8
    Related
    ENSP00000376344.3, ENST00000392561.7
    Conserved Domains (8) summary
    COG0724
    Location:477801
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12318
    Location:730809
    RRM5_RBM19_like; RNA recognition motif 5 in RNA-binding protein 19 (RBM19 or RBD-1) and similar proteins
    cd12502
    Location:294365
    RRM2_RMB19; RNA recognition motif 2 in RNA-binding protein 19 (RBM19) and similar proteins
    cd12564
    Location:277
    RRM1_RBM19; RNA recognition motif 1 in RNA-binding protein 19 (RBM19) and similar proteins
    cd12567
    Location:400478
    RRM3_RBM19; RNA recognition motif 3 in RNA-binding protein 19 (RBM19) and similar proteins
    cd12569
    Location:587658
    RRM4_RBM19; RNA recognition motif 4 in RNA-binding protein 19 (RBM19) and similar proteins
    cd12571
    Location:832910
    RRM6_RBM19; RNA recognition motif 6 in RNA-binding protein 19 (RBM19) and similar proteins
    pfam16651
    Location:82286
    RRM_u2; Unstructured region on RNA-binding-domain protein
  2. NM_001146699.2NP_001140171.1  probable RNA-binding protein 19

    See identical proteins and their annotated locations for NP_001140171.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC009731, AC090669, AI218902, AK291444, DB096676
    Consensus CDS
    CCDS9172.1
    UniProtKB/Swiss-Prot
    Q9Y4C8
    Related
    ENSP00000442053.2, ENST00000545145.6
    Conserved Domains (8) summary
    COG0724
    Location:477801
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12318
    Location:730809
    RRM5_RBM19_like; RNA recognition motif 5 in RNA-binding protein 19 (RBM19 or RBD-1) and similar proteins
    cd12502
    Location:294365
    RRM2_RMB19; RNA recognition motif 2 in RNA-binding protein 19 (RBM19) and similar proteins
    cd12564
    Location:277
    RRM1_RBM19; RNA recognition motif 1 in RNA-binding protein 19 (RBM19) and similar proteins
    cd12567
    Location:400478
    RRM3_RBM19; RNA recognition motif 3 in RNA-binding protein 19 (RBM19) and similar proteins
    cd12569
    Location:587658
    RRM4_RBM19; RNA recognition motif 4 in RNA-binding protein 19 (RBM19) and similar proteins
    cd12571
    Location:832910
    RRM6_RBM19; RNA recognition motif 6 in RNA-binding protein 19 (RBM19) and similar proteins
    pfam16651
    Location:82286
    RRM_u2; Unstructured region on RNA-binding-domain protein
  3. NM_016196.4NP_057280.2  probable RNA-binding protein 19

    See identical proteins and their annotated locations for NP_057280.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC009731, AC090669, AL117547, DB096676
    Consensus CDS
    CCDS9172.1
    UniProtKB/Swiss-Prot
    Q9Y4C8
    Related
    ENSP00000261741.5, ENST00000261741.10
    Conserved Domains (8) summary
    COG0724
    Location:477801
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12318
    Location:730809
    RRM5_RBM19_like; RNA recognition motif 5 in RNA-binding protein 19 (RBM19 or RBD-1) and similar proteins
    cd12502
    Location:294365
    RRM2_RMB19; RNA recognition motif 2 in RNA-binding protein 19 (RBM19) and similar proteins
    cd12564
    Location:277
    RRM1_RBM19; RNA recognition motif 1 in RNA-binding protein 19 (RBM19) and similar proteins
    cd12567
    Location:400478
    RRM3_RBM19; RNA recognition motif 3 in RNA-binding protein 19 (RBM19) and similar proteins
    cd12569
    Location:587658
    RRM4_RBM19; RNA recognition motif 4 in RNA-binding protein 19 (RBM19) and similar proteins
    cd12571
    Location:832910
    RRM6_RBM19; RNA recognition motif 6 in RNA-binding protein 19 (RBM19) and similar proteins
    pfam16651
    Location:82286
    RRM_u2; Unstructured region on RNA-binding-domain protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    113816740..113966371 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020280.1XP_016875769.1  probable RNA-binding protein 19 isoform X1

    Conserved Domains (8) summary
    COG0724
    Location:453777
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12318
    Location:706785
    RRM5_RBM19_like; RNA recognition motif 5 in RNA-binding protein 19 (RBM19 or RBD-1) and similar proteins
    cd12564
    Location:277
    RRM1_RBM19; RNA recognition motif 1 in RNA-binding protein 19 (RBM19) and similar proteins
    cd12567
    Location:376454
    RRM3_RBM19; RNA recognition motif 3 in RNA-binding protein 19 (RBM19) and similar proteins
    cd12569
    Location:563634
    RRM4_RBM19; RNA recognition motif 4 in RNA-binding protein 19 (RBM19) and similar proteins
    cd12571
    Location:808886
    RRM6_RBM19; RNA recognition motif 6 in RNA-binding protein 19 (RBM19) and similar proteins
    pfam16651
    Location:82286
    RRM_u2; Unstructured region on RNA-binding-domain protein
    cl17169
    Location:294341
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. XM_017020281.1XP_016875770.1  probable RNA-binding protein 19 isoform X1

    Conserved Domains (8) summary
    COG0724
    Location:453777
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12318
    Location:706785
    RRM5_RBM19_like; RNA recognition motif 5 in RNA-binding protein 19 (RBM19 or RBD-1) and similar proteins
    cd12564
    Location:277
    RRM1_RBM19; RNA recognition motif 1 in RNA-binding protein 19 (RBM19) and similar proteins
    cd12567
    Location:376454
    RRM3_RBM19; RNA recognition motif 3 in RNA-binding protein 19 (RBM19) and similar proteins
    cd12569
    Location:563634
    RRM4_RBM19; RNA recognition motif 4 in RNA-binding protein 19 (RBM19) and similar proteins
    cd12571
    Location:808886
    RRM6_RBM19; RNA recognition motif 6 in RNA-binding protein 19 (RBM19) and similar proteins
    pfam16651
    Location:82286
    RRM_u2; Unstructured region on RNA-binding-domain protein
    cl17169
    Location:294341
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. XR_001748932.1 RNA Sequence

  2. XR_944848.2 RNA Sequence

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