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KLHL21 kelch like family member 21 [ Homo sapiens (human) ]

Gene ID: 9903, updated on 29-Mar-2020

Summary

Official Symbol
KLHL21provided by HGNC
Official Full Name
kelch like family member 21provided by HGNC
Primary source
HGNC:HGNC:29041
See related
Ensembl:ENSG00000162413 MIM:616262
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in fat (RPKM 17.4), ovary (RPKM 14.2) and 25 other tissues See more
Orthologs

Genomic context

See KLHL21 in Genome Data Viewer
Location:
1p36.31
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (6590724..6602869, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (6650784..6662958, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene taste 1 receptor member 1 Neighboring gene uncharacterized LOC107984912 Neighboring gene zinc finger and BTB domain containing 48 Neighboring gene uncharacterized LOC107984913 Neighboring gene PHD finger protein 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0469, MGC99635

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cullin family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
COPII vesicle coating IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
chromosome passenger complex localization to spindle midzone IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein monoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
polar microtubule IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324309.2NP_001311238.1  kelch-like protein 21 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL591866
    Related
    ENSP00000366891.3, ENST00000377663.3
    Conserved Domains (5) summary
    PHA03098
    Location:49493
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:326368
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:25130
    BTB; BTB/POZ domain
    pfam01344
    Location:327368
    Kelch_1; Kelch motif
    pfam07707
    Location:138239
    BACK; BTB And C-terminal Kelch
  2. NM_014851.4NP_055666.2  kelch-like protein 21 isoform 1

    See identical proteins and their annotated locations for NP_055666.2

    Status: VALIDATED

    Source sequence(s)
    AB007938, BC064980
    Consensus CDS
    CCDS30575.1
    UniProtKB/Swiss-Prot
    Q9UJP4
    Related
    ENSP00000366886.4, ENST00000377658.8
    Conserved Domains (7) summary
    smart00612
    Location:482512
    Kelch; Kelch domain
    PHA03098
    Location:49547
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:326368
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:25130
    BTB; BTB/POZ domain
    pfam01344
    Location:327368
    Kelch_1; Kelch motif
    pfam07707
    Location:138239
    BACK; BTB And C-terminal Kelch
    pfam13964
    Location:502549
    Kelch_6; Kelch motif

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    6590724..6602869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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