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SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 [ Homo sapiens (human) ]

Gene ID: 9901, updated on 5-Aug-2022

Summary

Official Symbol
SRGAP3provided by HGNC
Official Full Name
SLIT-ROBO Rho GTPase activating protein 3provided by HGNC
Primary source
HGNC:HGNC:19744
See related
Ensembl:ENSG00000196220 MIM:606525; AllianceGenome:HGNC:19744
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WRP; MEGAP; SRGAP2; ARHGAP14
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of cell migration. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 6.5), urinary bladder (RPKM 1.5) and 16 other tissues See more
Orthologs
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Genomic context

See SRGAP3 in Genome Data Viewer
Location:
3p25.3
Exon count:
30
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (8980591..9363027, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (8971761..9240846, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9022275..9291330, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RAD18 E3 ubiquitin protein ligase Neighboring gene Sharpr-MPRA regulatory region 4351 Neighboring gene Sharpr-MPRA regulatory region 3594 Neighboring gene uncharacterized LOC124909343 Neighboring gene SRGAP3 antisense RNA 2 Neighboring gene SRGAP3 antisense RNA 3 Neighboring gene SRGAP3 antisense RNA 4 Neighboring gene phosphoglycerate mutase 1 pseudogene 4 Neighboring gene THUMPD3 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 11896 Neighboring gene THUMP domain containing 3 Neighboring gene SET domain containing 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0411

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
SLIT-ROBO Rho GTPase-activating protein 3
Names
SLIT-ROBO Rho GTPase activating protein 2
WAVE-associated Rac GTPase activating protein
mental disorder-associated GAP
rho GTPase-activating protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033117.3NP_001028289.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform b

    See identical proteins and their annotated locations for NP_001028289.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon and includes an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AF464189, AK054831, BM976179, DA532895
    Consensus CDS
    CCDS33689.1
    UniProtKB/Swiss-Prot
    O43295
    Related
    ENSP00000353587.3, ENST00000360413.7
    Conserved Domains (3) summary
    cd07684
    Location:26278
    F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
    cd11955
    Location:724776
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:481665
    RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...
  2. NM_014850.4NP_055665.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform a

    See identical proteins and their annotated locations for NP_055665.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AF427144, AK054831, BM976179, DA532895
    Consensus CDS
    CCDS2572.1
    UniProtKB/Swiss-Prot
    O43295, Q8IZV8
    Related
    ENSP00000373347.3, ENST00000383836.8
    Conserved Domains (3) summary
    cd07684
    Location:26278
    F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
    cd11955
    Location:748800
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:502689
    RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    8980591..9363027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453843.2XP_024309611.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X7

    Conserved Domains (3) summary
    cd11955
    Location:633685
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:390574
    RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...
    cl12013
    Location:1158
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. XM_047449335.1XP_047305291.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X11

  3. XM_047449333.1XP_047305289.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X6

  4. XM_024453842.2XP_024309610.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X5

    Conserved Domains (3) summary
    cd11955
    Location:732784
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:489673
    RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
    cl12013
    Location:26257
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  5. XM_047449336.1XP_047305292.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X12

  6. XM_047449334.1XP_047305290.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X10

  7. XM_011534295.3XP_011532597.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X2

    See identical proteins and their annotated locations for XP_011532597.1

    Conserved Domains (3) summary
    cd07684
    Location:26278
    F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
    cd11955
    Location:753805
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:510694
    RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
  8. XM_011534296.3XP_011532598.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X4

    Conserved Domains (3) summary
    cd07684
    Location:7259
    F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
    cd11955
    Location:734786
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:491675
    RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
  9. XM_017007575.2XP_016863064.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X3

  10. XM_017007574.2XP_016863063.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X1

  11. XM_017007579.2XP_016863068.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X9

  12. XM_011534301.4XP_011532603.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X8

    Conserved Domains (3) summary
    cd11955
    Location:590642
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:347531
    RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
    cl12013
    Location:1115
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  13. XM_047449337.1XP_047305293.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X13

  14. XM_047449338.1XP_047305294.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X14

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    8971761..9240846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033116.1: Suppressed sequence

    Description
    NM_001033116.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.