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UBAP2L ubiquitin associated protein 2 like [ Homo sapiens (human) ]

Gene ID: 9898, updated on 23-Dec-2018

Summary

Official Symbol
UBAP2Lprovided by HGNC
Official Full Name
ubiquitin associated protein 2 likeprovided by HGNC
Primary source
HGNC:HGNC:29877
See related
Ensembl:ENSG00000143569 MIM:616472
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NICE4; NICE-4
Expression
Ubiquitous expression in testis (RPKM 26.7), placenta (RPKM 21.3) and 25 other tissues See more
Orthologs

Genomic context

See UBAP2L in Genome Data Viewer
Location:
1q21.3
Exon count:
34
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (154220172..154271510)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154192427..154243986)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene microRNA 190b Neighboring gene chromosome 1 open reading frame 189 Neighboring gene chromosome 1 open reading frame 43 Neighboring gene small nucleolar RNA, H/ACA box 58B Neighboring gene HCLS1 associated protein X-1 Neighboring gene RNA, U6 small nuclear 239, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated ubiquitin associated protein 2-like (UBAP2L) is incorporated into HIV-1 Gag virus-like particles PubMed
Vpr vpr HIV-1 Vpr upregulates UBAP2L in HeLa cells within 12 hours of exposure PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ42300, KIAA0144

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
binding of sperm to zona pellucida IMP
Inferred from Mutant Phenotype
more info
PubMed 
hematopoietic stem cell homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hematopoietic stem cell homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with Ada2/Gcn5/Ada3 transcription activator complex IDA
Inferred from Direct Assay
more info
PubMed 
PcG protein complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin-associated protein 2-like
Names
protein NICE-4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127320.2NP_001120792.1  ubiquitin-associated protein 2-like isoform b

    See identical proteins and their annotated locations for NP_001120792.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the UTRs and 3' coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    D63478, DC369803
    Consensus CDS
    CCDS44229.1
    UniProtKB/Swiss-Prot
    Q14157
    Related
    ENSP00000345308.6, ENST00000343815.10
    Conserved Domains (2) summary
    cd14277
    Location:5087
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:496523
    DUF3697; Ubiquitin-associated protein 2
  2. NM_001287815.1NP_001274744.1  ubiquitin-associated protein 2-like isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the UTRs, uses an alternate in-frame splice site in the central coding region, and uses an alternate 3'-terminal exon, compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK303533, D63478, DC404293
    Consensus CDS
    CCDS72925.1
    UniProtKB/Swiss-Prot
    Q14157
    Related
    ENSP00000478447.1, ENST00000613315.4
    Conserved Domains (2) summary
    cd14277
    Location:5087
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:489516
    DUF3697; Ubiquitin-associated protein 2
  3. NM_001287816.1NP_001274745.1  ubiquitin-associated protein 2-like isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the central coding region, and uses an alternate 3'-terminal exon, compared to variant 1. The encoded isoform (d) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AJ243670, AK302662, D63478, DC404293
    UniProtKB/Swiss-Prot
    Q14157
    UniProtKB/TrEMBL
    B4DYY5
    Conserved Domains (2) summary
    cd14277
    Location:5087
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:507534
    DUF3697; Ubiquitin-associated protein 2
  4. NM_001330730.1NP_001317659.1  ubiquitin-associated protein 2-like isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice junction and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (e) contains an alternate internal segment and has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL590431
    Consensus CDS
    CCDS81381.1
    UniProtKB/TrEMBL
    F8W726
    Related
    ENSP00000271877.8, ENST00000271877.11
    Conserved Domains (2) summary
    cd14277
    Location:5087
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:507534
    DUF3697; Ubiquitin-associated protein 2
  5. NM_014847.4NP_055662.3  ubiquitin-associated protein 2-like isoform a

    See identical proteins and their annotated locations for NP_055662.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    BC003170, D63478, DC404293
    Consensus CDS
    CCDS1063.1
    UniProtKB/Swiss-Prot
    Q14157
    Related
    ENSP00000389445.1, ENST00000428931.5
    Conserved Domains (2) summary
    cd14277
    Location:5087
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:496523
    DUF3697; Ubiquitin-associated protein 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    154220172..154271510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002976.1XP_016858465.1  ubiquitin-associated protein 2-like isoform X5

    Conserved Domains (2) summary
    cd14277
    Location:5087
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:507534
    DUF3697; Ubiquitin-associated protein 2
  2. XM_017002986.2XP_016858475.1  ubiquitin-associated protein 2-like isoform X14

    UniProtKB/Swiss-Prot
    Q14157
  3. XM_017002982.2XP_016858471.1  ubiquitin-associated protein 2-like isoform X11

  4. XM_005245672.4XP_005245729.1  ubiquitin-associated protein 2-like isoform X15

    Conserved Domains (2) summary
    cd14277
    Location:5087
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:496523
    DUF3697; Ubiquitin-associated protein 2
  5. XM_011510216.2XP_011508518.1  ubiquitin-associated protein 2-like isoform X3

    See identical proteins and their annotated locations for XP_011508518.1

    UniProtKB/Swiss-Prot
    Q14157
    Conserved Domains (2) summary
    cd14277
    Location:5087
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:496523
    DUF3697; Ubiquitin-associated protein 2
  6. XM_017002973.2XP_016858462.1  ubiquitin-associated protein 2-like isoform X4

  7. XM_017002977.2XP_016858466.1  ubiquitin-associated protein 2-like isoform X9

  8. XM_005245674.2XP_005245731.1  ubiquitin-associated protein 2-like isoform X17

    See identical proteins and their annotated locations for XP_005245731.1

    UniProtKB/Swiss-Prot
    Q14157
    Conserved Domains (2) summary
    cd14277
    Location:5087
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:496523
    DUF3697; Ubiquitin-associated protein 2
  9. XM_005245668.4XP_005245725.1  ubiquitin-associated protein 2-like isoform X7

    Conserved Domains (2) summary
    cd14277
    Location:5087
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:507534
    DUF3697; Ubiquitin-associated protein 2
  10. XM_005245669.4XP_005245726.1  ubiquitin-associated protein 2-like isoform X8

    Conserved Domains (2) summary
    cd14277
    Location:5087
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:507534
    DUF3697; Ubiquitin-associated protein 2
  11. XM_005245667.4XP_005245724.1  ubiquitin-associated protein 2-like isoform X5

    Conserved Domains (2) summary
    cd14277
    Location:5087
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:507534
    DUF3697; Ubiquitin-associated protein 2
  12. XM_005245658.4XP_005245715.1  ubiquitin-associated protein 2-like isoform X1

    See identical proteins and their annotated locations for XP_005245715.1

    Conserved Domains (2) summary
    cd14277
    Location:5087
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:507534
    DUF3697; Ubiquitin-associated protein 2
  13. XM_011510215.3XP_011508517.1  ubiquitin-associated protein 2-like isoform X2

    Conserved Domains (2) summary
    cd14277
    Location:5087
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:507534
    DUF3697; Ubiquitin-associated protein 2
  14. XM_017002975.2XP_016858464.1  ubiquitin-associated protein 2-like isoform X6

  15. XM_005245673.4XP_005245730.1  ubiquitin-associated protein 2-like isoform X16

    Conserved Domains (2) summary
    cd14277
    Location:5087
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:507534
    DUF3697; Ubiquitin-associated protein 2
  16. XM_024451291.1XP_024307059.1  ubiquitin-associated protein 2-like isoform X18

    Conserved Domains (1) summary
    pfam12478
    Location:266293
    DUF3697; Ubiquitin-associated protein 2
  17. XM_017002983.1XP_016858472.1  ubiquitin-associated protein 2-like isoform X12

    Conserved Domains (2) summary
    cd14277
    Location:5087
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:496523
    DUF3697; Ubiquitin-associated protein 2
  18. XM_017002987.1XP_016858476.1  ubiquitin-associated protein 2-like isoform X14

    UniProtKB/Swiss-Prot
    Q14157
  19. XM_017002984.1XP_016858473.1  ubiquitin-associated protein 2-like isoform X11

  20. XM_017002988.1XP_016858477.1  ubiquitin-associated protein 2-like isoform X15

    Conserved Domains (2) summary
    cd14277
    Location:5087
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:496523
    DUF3697; Ubiquitin-associated protein 2
  21. XM_017002978.1XP_016858467.1  ubiquitin-associated protein 2-like isoform X10

    UniProtKB/Swiss-Prot
    Q14157
    Conserved Domains (2) summary
    cd14277
    Location:5087
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:496523
    DUF3697; Ubiquitin-associated protein 2
  22. XM_017002974.1XP_016858463.1  ubiquitin-associated protein 2-like isoform X4

  23. XM_017002980.2XP_016858469.1  ubiquitin-associated protein 2-like isoform X9

  24. XM_017002989.1XP_016858478.1  ubiquitin-associated protein 2-like isoform X17

    UniProtKB/Swiss-Prot
    Q14157
    Conserved Domains (2) summary
    cd14277
    Location:5087
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:496523
    DUF3697; Ubiquitin-associated protein 2
  25. XM_017002985.2XP_016858474.1  ubiquitin-associated protein 2-like isoform X13

    UniProtKB/TrEMBL
    F8W726
    Conserved Domains (2) summary
    cd14277
    Location:5087
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:507534
    DUF3697; Ubiquitin-associated protein 2
  26. XM_017002972.2XP_016858461.1  ubiquitin-associated protein 2-like isoform X2

    Conserved Domains (2) summary
    cd14277
    Location:5087
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:507534
    DUF3697; Ubiquitin-associated protein 2
  27. XM_017002979.1XP_016858468.1  ubiquitin-associated protein 2-like isoform X10

    UniProtKB/Swiss-Prot
    Q14157
    Related
    ENSP00000355343.2, ENST00000361546.6
    Conserved Domains (2) summary
    cd14277
    Location:5087
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:496523
    DUF3697; Ubiquitin-associated protein 2
  28. XM_017002981.2XP_016858470.1  ubiquitin-associated protein 2-like isoform X9

  29. XM_017002990.1XP_016858479.1  ubiquitin-associated protein 2-like isoform X17

    UniProtKB/Swiss-Prot
    Q14157
    Conserved Domains (2) summary
    cd14277
    Location:5087
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:496523
    DUF3697; Ubiquitin-associated protein 2
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