U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LRRC37A leucine rich repeat containing 37A [ Homo sapiens (human) ]

Gene ID: 9884, updated on 22-Sep-2022

Summary

Official Symbol
LRRC37Aprovided by HGNC
Official Full Name
leucine rich repeat containing 37Aprovided by HGNC
Primary source
HGNC:HGNC:29069
See related
Ensembl:ENSG00000176681 MIM:616555; AllianceGenome:HGNC:29069
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRRC37
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 14.7), bone marrow (RPKM 4.6) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See LRRC37A in Genome Data Viewer
Location:
17q21.31
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (46248044..46337794)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (47157142..47199790)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (44372497..44415160)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene KAT8 regulatory NSL complex subunit 1 Neighboring gene KANSL1 antisense RNA 1 Neighboring gene chromosome 17 open reading frame 58 pseudogene Neighboring gene mitogen-activated protein kinase 8 interacting protein 1 pseudogene 1 Neighboring gene uncharacterized LOC124904014 Neighboring gene DND microRNA-mediated repression inhibitor 1 pseudogene 2 Neighboring gene ADP ribosylation factor like GTPase 17B Neighboring gene RNA, 7SL, cytoplasmic 656, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7330 Neighboring gene leucine rich repeat containing 37 member A2 Neighboring gene N-ethylmaleimide-sensitive factor pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0563, DKFZp686N1231

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat-containing protein 37A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014834.4NP_055649.4  leucine-rich repeat-containing protein 37A precursor

    See identical proteins and their annotated locations for NP_055649.4

    Status: VALIDATED

    Source sequence(s)
    AC005829, AC217777
    Consensus CDS
    CCDS11504.2
    UniProtKB/Swiss-Prot
    A6NMS7, Q8IWC7
    Related
    ENSP00000326324.5, ENST00000320254.5
    Conserved Domains (5) summary
    sd00031
    Location:891914
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:892929
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:892949
    LRR_8; Leucine rich repeat
    pfam14914
    Location:14681613
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
    pfam15779
    Location:561629
    LRRC37; Leucine-rich repeat-containing protein 37 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    46248044..46337794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047437205.1XP_047293161.1  leucine-rich repeat-containing protein 37A isoform X10

  2. XM_047437200.1XP_047293156.1  leucine-rich repeat-containing protein 37A isoform X5

  3. XM_047437206.1XP_047293162.1  leucine-rich repeat-containing protein 37A isoform X11

    UniProtKB/TrEMBL
    E9PP10
    Related
    ENSP00000437021.1, ENST00000496930.5
  4. XM_047437196.1XP_047293152.1  leucine-rich repeat-containing protein 37A isoform X1

  5. XM_047437197.1XP_047293153.1  leucine-rich repeat-containing protein 37A isoform X2

  6. XM_047437198.1XP_047293154.1  leucine-rich repeat-containing protein 37A isoform X3

  7. XM_047437199.1XP_047293155.1  leucine-rich repeat-containing protein 37A isoform X4

  8. XM_047437201.1XP_047293157.1  leucine-rich repeat-containing protein 37A isoform X6

  9. XM_047437202.1XP_047293158.1  leucine-rich repeat-containing protein 37A isoform X7

  10. XM_047437204.1XP_047293160.1  leucine-rich repeat-containing protein 37A isoform X9

  11. XM_047437203.1XP_047293159.1  leucine-rich repeat-containing protein 37A isoform X8

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_167251.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    413631..456611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    47157142..47199790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)