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TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1 [ Homo sapiens (human) ]

Gene ID: 9881, updated on 5-Aug-2018

Summary

Official Symbol
TRANK1provided by HGNC
Official Full Name
tetratricopeptide repeat and ankyrin repeat containing 1provided by HGNC
Primary source
HGNC:HGNC:29011
See related
Ensembl:ENSG00000168016 Vega:OTTHUMG00000155848
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LBA1
Expression
Ubiquitous expression in endometrium (RPKM 7.0), lymph node (RPKM 6.9) and 24 other tissues See more
Orthologs

Genomic context

See TRANK1 in Genome Data Viewer
Location:
3p22.2
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (36826817..36945662, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (36868308..36986548, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377030 Neighboring gene long intergenic non-protein coding RNA 2033 Neighboring gene chromobox protein homolog 3 pseudogene Neighboring gene RNA, U6atac small nuclear 4, pseudogene Neighboring gene protease associated domain containing 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Genome-wide association of mood-incongruent psychotic bipolar disorder.
NHGRI GWA Catalog
Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.
NHGRI GWA Catalog
Genome-wide association study reveals two new risk loci for bipolar disorder.
NHGRI GWA Catalog
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
NHGRI GWA Catalog
Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0342

General protein information

Preferred Names
TPR and ankyrin repeat-containing protein 1
Names
lupus brain antigen 1 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329998.1NP_001316927.1  TPR and ankyrin repeat-containing protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC011816, AC097360, AC105749
    Consensus CDS
    CCDS87061.1
    Related
    ENSP00000494480.1, ENST00000645898.1
    Conserved Domains (5) summary
    cd00204
    Location:514633
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:1543
    TPR; TPR repeat [structural motif]
    pfam12796
    Location:517625
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:1590
    TPR_11; TPR repeat
    sd00045
    Location:246282
    ANK; ANK repeat [structural motif]
  2. NM_014831.2NP_055646.2  TPR and ankyrin repeat-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_055646.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AB002340, AC011816, AC097360, AC105749, BG750754, BG960452, BQ024165, CD698859, CN482191, EG328357, EG328358
    Consensus CDS
    CCDS46789.2
    UniProtKB/Swiss-Prot
    O15050
    Related
    ENSP00000416168.2, OTTHUMP00000222365, ENST00000429976.5, OTTHUMT00000369655
    Conserved Domains (5) summary
    cd00204
    Location:470589
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:1344
    TPR; TPR repeat [structural motif]
    pfam12796
    Location:473581
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:1578
    TPR_11; TPR repeat
    sd00045
    Location:202238
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    36826817..36945662 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007571.1XP_016863060.1  TPR and ankyrin repeat-containing protein 1 isoform X3

  2. XM_017007570.1XP_016863059.1  TPR and ankyrin repeat-containing protein 1 isoform X2

  3. XM_011534289.2XP_011532591.1  TPR and ankyrin repeat-containing protein 1 isoform X1

    Conserved Domains (5) summary
    cd00204
    Location:515634
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:1644
    TPR; TPR repeat [structural motif]
    pfam12796
    Location:518626
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:1691
    TPR_11; TPR repeat
    sd00045
    Location:247283
    ANK; ANK repeat [structural motif]
  4. XM_017007572.1XP_016863061.1  TPR and ankyrin repeat-containing protein 1 isoform X4

    Conserved Domains (5) summary
    cd00204
    Location:506625
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:735
    TPR; TPR repeat [structural motif]
    pfam12796
    Location:509617
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:782
    TPR_11; TPR repeat
    sd00045
    Location:238274
    ANK; ANK repeat [structural motif]
  5. XM_017007573.1XP_016863062.1  TPR and ankyrin repeat-containing protein 1 isoform X5

    Related
    ENSP00000496771.1, ENST00000646897.1

RNA

  1. XR_001740389.1 RNA Sequence

  2. XR_001740390.1 RNA Sequence

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