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Trank1 tetratricopeptide repeat and ankyrin repeat containing 1 [ Mus musculus (house mouse) ]

Gene ID: 320429, updated on 26-Sep-2022

Summary

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Official Symbol
Trank1provided by MGI
Official Full Name
tetratricopeptide repeat and ankyrin repeat containing 1provided by MGI
Primary source
MGI:MGI:1341834
See related
Ensembl:ENSMUSG00000062296 AllianceGenome:MGI:1341834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lba1; Gm187; A230061D21Rik; C030048J01Rik
Summary
Is expressed in adrenal cortex; central nervous system; frenulum; lung; and seminiferous cord. Orthologous to human TRANK1 (tetratricopeptide repeat and ankyrin repeat containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 42.3), cortex adult (RPKM 41.4) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Trank1 in Genome Data Viewer
Location:
9; 9 F3
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (111140351..111224843)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (111311283..111395775)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51692 Neighboring gene mutL homolog 1 Neighboring gene EPM2A (laforin) interacting protein 1 Neighboring gene doublecortin-like kinase 3 Neighboring gene ribosomal protein L7A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and cloning of a brain autoantigen in neuro-behavioral SLE. Moore PM, et al. J Neuroimmunol, 1998 Mar 1. PMID 9585807
  2. Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells. McClelland KS, et al. Biol Reprod, 2015 Jun. PMID 25855264
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (14) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
TPR and ankyrin repeat-containing protein 1
Names
lupus brain antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164659.1 → NP_001158131.1  TPR and ankyrin repeat-containing protein 1

    See identical proteins and their annotated locations for NP_001158131.1

    Status: VALIDATED

    Source sequence(s)
    AC113495, AK079552, BC086653, BY728326
    Consensus CDS
    CCDS52942.1
    UniProtKB/Swiss-Prot
    Q6ZQD5, Q8BV79
    Related
    ENSMUSP00000077697.4, ENSMUST00000078626.8
    Conserved Domains (5) summary
    cd00204
    Location:542 → 664
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:144 → 172
    TPR; TPR repeat [structural motif]
    pfam12796
    Location:543 → 656
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:144 → 207
    TPR_11; TPR repeat
    sd00045
    Location:542 → 569
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    111140351..111224843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512160.4 → XP_006512223.1  TPR and ankyrin repeat-containing protein 1 isoform X1

    Conserved Domains (5) summary
    PHA03381
    Location:22 → 136
    PHA03381; tegument protein VP22; Provisional
    PHA03095
    Location:317 → 432
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:498 → 681
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:144 → 172
    TPR; TPR repeat [structural motif]
    sd00045
    Location:552 → 579
    ANK; ANK repeat [structural motif]

  2. XM_017313432.2 → XP_017168921.1  TPR and ankyrin repeat-containing protein 1 isoform X3

    Conserved Domains (5) summary
    PHA03381
    Location:22 → 136
    PHA03381; tegument protein VP22; Provisional
    PHA03095
    Location:316 → 431
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:497 → 680
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:144 → 172
    TPR; TPR repeat [structural motif]
    sd00045
    Location:551 → 578
    ANK; ANK repeat [structural motif]

  3. XM_006512161.4 → XP_006512224.1  TPR and ankyrin repeat-containing protein 1 isoform X2

    Conserved Domains (5) summary
    PHA03381
    Location:22 → 136
    PHA03381; tegument protein VP22; Provisional
    PHA03095
    Location:316 → 431
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:497 → 680
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:144 → 172
    TPR; TPR repeat [structural motif]
    sd00045
    Location:551 → 578
    ANK; ANK repeat [structural motif]

  4. XM_006512162.4 → XP_006512225.1  TPR and ankyrin repeat-containing protein 1 isoform X4

    Conserved Domains (5) summary
    PHA03381
    Location:22 → 136
    PHA03381; tegument protein VP22; Provisional
    PHA03095
    Location:308 → 423
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:489 → 672
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:144 → 172
    TPR; TPR repeat [structural motif]
    sd00045
    Location:543 → 570
    ANK; ANK repeat [structural motif]

  5. XM_006512164.4 → XP_006512227.1  TPR and ankyrin repeat-containing protein 1 isoform X6

    Conserved Domains (6) summary
    PHA03381
    Location:22 → 136
    PHA03381; tegument protein VP22; Provisional
    COG0666
    Location:498 → 681
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    TIGR02785
    Location:1472 → 1559
    addA_Gpos; helicase-exonuclease AddAB, AddA subunit, Firmicutes type
    sd00006
    Location:144 → 172
    TPR; TPR repeat [structural motif]
    sd00045
    Location:552 → 579
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:322 → 417
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_006512163.5 → XP_006512226.1  TPR and ankyrin repeat-containing protein 1 isoform X5

    Conserved Domains (4) summary
    PHA03095
    Location:209 → 324
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:390 → 573
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:36 → 64
    TPR; TPR repeat [structural motif]
    sd00045
    Location:444 → 471
    ANK; ANK repeat [structural motif]

RNA

  1. XR_379871.4 RNA Sequence

  2. XR_004935454.1 RNA Sequence

  3. XR_379872.3 RNA Sequence

  4. XR_003947933.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BV79.3 GenPept UniProtKB/Swiss-Prot:Q8BV79

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