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PJA2 praja ring finger ubiquitin ligase 2 [ Homo sapiens (human) ]

Gene ID: 9867, updated on 22-May-2022

Summary

Official Symbol
PJA2provided by HGNC
Official Full Name
praja ring finger ubiquitin ligase 2provided by HGNC
Primary source
HGNC:HGNC:17481
See related
Ensembl:ENSG00000198961 MIM:619341; AllianceGenome:HGNC:17481
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF131; Neurodap1
Summary
Enables protein kinase A catalytic subunit binding activity; protein kinase A regulatory subunit binding activity; and ubiquitin-protein transferase activity. Involved in several processes, including protein ubiquitination; regulation of macrophage activation; and regulation of signal transduction. Located in cytoplasm; intermediate filament cytoskeleton; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 108.1), thyroid (RPKM 63.6) and 24 other tissues See more
Orthologs
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Genomic context

See PJA2 in Genome Data Viewer
Location:
5q21.3
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (109334722..109409974, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (109838178..109914589, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (108670423..108745675, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene FER tyrosine kinase Neighboring gene uncharacterized LOC124901040 Neighboring gene uncharacterized LOC285638 Neighboring gene Sharpr-MPRA regulatory region 6746 Neighboring gene uncharacterized LOC105379117 Neighboring gene Sharpr-MPRA regulatory region 13215 Neighboring gene keratin 18 pseudogene 42

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0438

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase A catalytic subunit binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein kinase A regulatory subunit binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in hippo signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-term memory ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of toll-like receptor 2 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of macrophage activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein kinase A signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of protein kinase A signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase Praja-2
Names
RING-type E3 ubiquitin transferase Praja-2
praja 2, RING-H2 motif containing
praja ring finger 2, E3 ubiquitin protein ligase
praja2
ring finger protein 131
NP_055634.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014819.5NP_055634.3  E3 ubiquitin-protein ligase Praja-2

    See identical proteins and their annotated locations for NP_055634.3

    Status: VALIDATED

    Source sequence(s)
    AB007898, BM469517, BP301854, BQ228553
    Consensus CDS
    CCDS4099.1
    UniProtKB/Swiss-Prot
    O43164
    Related
    ENSP00000354775.2, ENST00000361189.7
    Conserved Domains (1) summary
    pfam13639
    Location:634675
    zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    109334722..109409974 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    109838178..109914589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)