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Pja2 praja ring finger ubiquitin ligase 2 [ Mus musculus (house mouse) ]

Gene ID: 224938, updated on 8-Jan-2023

Summary

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Official Symbol
Pja2provided by MGI
Official Full Name
praja ring finger ubiquitin ligase 2provided by MGI
Primary source
MGI:MGI:2159342
See related
Ensembl:ENSMUSG00000024083 AllianceGenome:MGI:2159342
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Neurodap1; mKIAA0438
Summary
Predicted to enable protein kinase A catalytic subunit binding activity; protein kinase A regulatory subunit binding activity; and ubiquitin-protein transferase activity. Predicted to be involved in several processes, including long-term memory; regulation of macrophage activation; and regulation of signal transduction. Predicted to be located in cytoplasm; intermediate filament cytoskeleton; and plasma membrane. Is expressed in nervous system and testis. Orthologous to human PJA2 (praja ring finger ubiquitin ligase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 42.7), cortex adult (RPKM 39.3) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Pja2 in Genome Data Viewer
Location:
17; 17 E1.1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (64588001..64638878, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (64281006..64331883, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36, pseudogene 6 Neighboring gene predicted gene, 34858 Neighboring gene microRNA 6420 Neighboring gene expressed sequence AU016765 Neighboring gene predicted gene, 35098

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulatory function of praja ring finger ubiquitin ligase 2 mediated by the P2rx3/P2rx7 axis in mouse hippocampal neuronal cells. Gong M, et al. Am J Physiol Cell Physiol, 2020 Jun 1. PMID 32267716
  2. praja2 regulates KSR1 stability and mitogenic signaling. Rinaldi L, et al. Cell Death Dis, 2016 May 19. PMID 27195677, Free PMC Article
  3. Proteolytic control of neurite outgrowth inhibitor NOGO-A by the cAMP/PKA pathway. Sepe M, et al. Proc Natl Acad Sci U S A, 2014 Nov 4. PMID 25331889, Free PMC Article
  4. Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation. Sakamaki J, et al. Nat Cell Biol, 2014 Mar. PMID 24561619, Free PMC Article
  5. PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain. Yu P, et al. Genomics, 2002 Jun. PMID 12036302

See all (30) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pja2 regulated hippocampal neuronal cell development and the expression of Alzheimer disease marker genes by inhibiting P2rx3/promoting P2rx7 expression.
    Title: Regulatory function of praja ring finger ubiquitin ligase 2 mediated by the P2rx3/P2rx7 axis in mouse hippocampal neuronal cells.
  2. praja2 regulates KSR1 stability and mitogenic signaling.
    Title: praja2 regulates KSR1 stability and mitogenic signaling.
  3. The SIK2-p35-PJA2 complex is essential for glucose homeostasis and provides a link between p35-CDK5 and the AMPK family in excitable cells.
    Title: Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC27629

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase A catalytic subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase A regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in hippo signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in long-term memory ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of toll-like receptor 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of macrophage activation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein kinase A signaling IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase Praja-2
Names
E3 ubiquitin-protein ligase Praja2
RING finger protein 131
RING-type E3 ubiquitin transferase Praja-2
neurodegeneration associated protein 1
praja 2, RING-H2 motif containing
praja-2
praja2
protein carrying the RING-H2 sequence motif
NP_001020480.1
NP_659108.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025309.1 → NP_001020480.1  E3 ubiquitin-protein ligase Praja-2 isoform a

    See identical proteins and their annotated locations for NP_001020480.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AK122282, BY065517
    Consensus CDS
    CCDS37675.1
    UniProtKB/Swiss-Prot
    Q80U04, Q99KC0
    Related
    ENSMUSP00000134380.2, ENSMUST00000172818.8
    Conserved Domains (1) summary
    pfam13639
    Location:633 → 674
    zf-RING_2; Ring finger domain

  2. NM_144859.2 → NP_659108.1  E3 ubiquitin-protein ligase Praja-2 isoform b

    See identical proteins and their annotated locations for NP_659108.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AA067149, AK122282, BC017130, BX518494, BY065517
    Consensus CDS
    CCDS37674.1
    UniProtKB/Swiss-Prot
    Q80U04
    Related
    ENSMUSP00000133730.2, ENSMUST00000172733.2
    Conserved Domains (1) summary
    pfam13639
    Location:571 → 612
    zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    64588001..64638878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80U04.2 GenPept UniProtKB/Swiss-Prot:Q80U04

Gene LinkOut

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