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TRIL TLR4 interactor with leucine rich repeats [ Homo sapiens (human) ]

Gene ID: 9865, updated on 1-Jun-2020

Summary

Official Symbol
TRILprovided by HGNC
Official Full Name
TLR4 interactor with leucine rich repeatsprovided by HGNC
Primary source
HGNC:HGNC:22200
See related
Ensembl:ENSG00000255690 MIM:613356
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
TRIL is a component of the TLR4 (MIM 603030) complex and is induced in a number of cell types by lipopolysaccharide (LPS) (Carpenter et al., 2009 [PubMed 19710467]).[supplied by OMIM, Apr 2010]
Orthologs

Genomic context

See TRIL in Genome Data Viewer
Location:
7p14.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (28953358..28958330, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (28992974..28998029, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cAMP responsive element binding protein 5 Neighboring gene ribosomal protein S2 pseudogene 30 Neighboring gene Sharpr-MPRA regulatory region 6215 Neighboring gene uncharacterized LOC100506497 Neighboring gene carboxypeptidase vitellogenic like Neighboring gene CPVL antisense RNA 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • KIAA0644

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipopolysaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
regulation of cytokine production involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cytokine production involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
toll-like receptor 4 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
toll-like receptor 4 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipopolysaccharide receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipopolysaccharide receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
TLR4 interactor with leucine rich repeats

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014817.4NP_055632.2  TLR4 interactor with leucine rich repeats precursor

    See identical proteins and their annotated locations for NP_055632.2

    Status: VALIDATED

    Source sequence(s)
    AC005013, BC036337
    Consensus CDS
    CCDS75573.1
    UniProtKB/Swiss-Prot
    Q7L0X0
    Related
    ENSP00000479256.1, ENST00000539664.3
    Conserved Domains (5) summary
    cd00116
    Location:249364
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:351363
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:85108
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:589667
    fn3; Fibronectin type III domain
    pfam13855
    Location:84143
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    28953358..28958330 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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