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ARMCX2 armadillo repeat containing X-linked 2 [ Homo sapiens (human) ]

Gene ID: 9823, updated on 5-Jan-2020

Summary

Official Symbol
ARMCX2provided by HGNC
Official Full Name
armadillo repeat containing X-linked 2provided by HGNC
Primary source
HGNC:HGNC:16869
See related
Ensembl:ENSG00000184867 MIM:300363
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALEX2; GASP9
Summary
This gene encodes a protein containing a potential N-terminal transmembrane domain and multiple armadillo (arm) repeats. Proteins containing arm repeats are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is located in a cluster of related genes on chromosome X. There is a pseudogene for this gene on chromosome 7. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2013]
Expression
Broad expression in thyroid (RPKM 33.9), ovary (RPKM 22.0) and 22 other tissues See more
Orthologs

Genomic context

See ARMCX2 in Genome Data Viewer
Location:
Xq22.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (101655281..101659878, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (100910267..100914894, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing X-linked 3 Neighboring gene RNA, U6 small nuclear 30, pseudogene Neighboring gene mitochondrial fission factor pseudogene Neighboring gene RNA, U6 small nuclear 587, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8742, KIAA0512, MGC13343

Gene Ontology Provided by GOA

Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
armadillo repeat-containing X-linked protein 2
Names
ARM protein lost in epithelial cancers on chromosome X 2
armadillo repeat protein ALEX2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013221.2 RefSeqGene

    Range
    5029..9598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001282231.2NP_001269160.1  armadillo repeat-containing X-linked protein 2

    See identical proteins and their annotated locations for NP_001269160.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC234775, BC015926, BG548388, BX648494, CN391032
    Consensus CDS
    CCDS14490.1
    UniProtKB/Swiss-Prot
    Q7L311
    UniProtKB/TrEMBL
    A0A024RCG7
    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  2. NM_014782.7NP_055597.1  armadillo repeat-containing X-linked protein 2

    See identical proteins and their annotated locations for NP_055597.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC234775, BC012541, BC015926, BG548388
    Consensus CDS
    CCDS14490.1
    UniProtKB/Swiss-Prot
    Q7L311
    UniProtKB/TrEMBL
    A0A024RCG7
    Related
    ENSP00000331662.5, ENST00000328766.9
    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  3. NM_177949.4NP_808818.1  armadillo repeat-containing X-linked protein 2

    See identical proteins and their annotated locations for NP_808818.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC234775, AK291342, BC015926
    Consensus CDS
    CCDS14490.1
    UniProtKB/Swiss-Prot
    Q7L311
    UniProtKB/TrEMBL
    A0A024RCG7, A8K5M7
    Related
    ENSP00000349281.4, ENST00000356824.9
    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    101655281..101659878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005278113.1XP_005278170.1  armadillo repeat-containing X-linked protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005278170.1

    UniProtKB/Swiss-Prot
    Q7L311
    UniProtKB/TrEMBL
    A0A024RCG7
    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  2. XM_005278115.1XP_005278172.1  armadillo repeat-containing X-linked protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005278172.1

    UniProtKB/Swiss-Prot
    Q7L311
    UniProtKB/TrEMBL
    A0A024RCG7
    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  3. XM_005278114.1XP_005278171.1  armadillo repeat-containing X-linked protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005278171.1

    UniProtKB/Swiss-Prot
    Q7L311
    UniProtKB/TrEMBL
    A0A024RCG7
    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  4. XM_017029991.1XP_016885480.1  armadillo repeat-containing X-linked protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q7L311
    UniProtKB/TrEMBL
    A0A024RCG7
    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  5. XM_005278117.1XP_005278174.1  armadillo repeat-containing X-linked protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005278174.1

    UniProtKB/Swiss-Prot
    Q7L311
    UniProtKB/TrEMBL
    A0A024RCG7
    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  6. XM_005278111.1XP_005278168.1  armadillo repeat-containing X-linked protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005278168.1

    UniProtKB/Swiss-Prot
    Q7L311
    UniProtKB/TrEMBL
    A0A024RCG7
    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  7. XM_005278110.1XP_005278167.1  armadillo repeat-containing X-linked protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005278167.1

    UniProtKB/Swiss-Prot
    Q7L311
    UniProtKB/TrEMBL
    A0A024RCG7
    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  8. XM_011531071.1XP_011529373.1  armadillo repeat-containing X-linked protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011529373.1

    UniProtKB/Swiss-Prot
    Q7L311
    UniProtKB/TrEMBL
    A0A024RCG7
    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  9. XM_005278116.1XP_005278173.1  armadillo repeat-containing X-linked protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005278173.1

    UniProtKB/Swiss-Prot
    Q7L311
    UniProtKB/TrEMBL
    A0A024RCG7
    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  10. XM_017029990.1XP_016885479.1  armadillo repeat-containing X-linked protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q7L311
    UniProtKB/TrEMBL
    A0A024RCG7
    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  11. XM_005278109.1XP_005278166.1  armadillo repeat-containing X-linked protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005278166.1

    UniProtKB/Swiss-Prot
    Q7L311
    UniProtKB/TrEMBL
    A0A024RCG7
    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  12. XM_017029992.1XP_016885481.1  armadillo repeat-containing X-linked protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q7L311
    UniProtKB/TrEMBL
    A0A024RCG7
    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  13. XM_011531072.1XP_011529374.1  armadillo repeat-containing X-linked protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011529374.1

    UniProtKB/Swiss-Prot
    Q7L311
    UniProtKB/TrEMBL
    A0A024RCG7
    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  14. XM_024452483.1XP_024308251.1  armadillo repeat-containing X-linked protein 2 isoform X1

    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  15. XM_017029988.2XP_016885477.1  armadillo repeat-containing X-linked protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q7L311
    UniProtKB/TrEMBL
    A0A024RCG7
    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  16. XM_017029987.2XP_016885476.1  armadillo repeat-containing X-linked protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q7L311
    UniProtKB/TrEMBL
    A0A024RCG7
    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  17. XM_017029994.1XP_016885483.1  armadillo repeat-containing X-linked protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q7L311
    UniProtKB/TrEMBL
    A0A024RCG7
    Related
    ENSP00000328631.2, ENST00000330154.6
    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  18. XM_017029993.1XP_016885482.1  armadillo repeat-containing X-linked protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q7L311
    UniProtKB/TrEMBL
    A0A024RCG7
    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  19. XM_017029989.1XP_016885478.1  armadillo repeat-containing X-linked protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q7L311
    UniProtKB/TrEMBL
    A0A024RCG7
    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  20. XM_017029995.1XP_016885484.1  armadillo repeat-containing X-linked protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q7L311
    UniProtKB/TrEMBL
    A0A024RCG7
    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  21. XM_024452484.1XP_024308252.1  armadillo repeat-containing X-linked protein 2 isoform X1

    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  22. XM_017029996.1XP_016885485.1  armadillo repeat-containing X-linked protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q7L311
    UniProtKB/TrEMBL
    A0A024RCG7
    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  23. XM_017029997.1XP_016885486.1  armadillo repeat-containing X-linked protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q7L311
    UniProtKB/TrEMBL
    A0A024RCG7
    Conserved Domains (3) summary
    sd00044
    Location:391416
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:377626
    Arm_2; Armadillo-like
    cl26386
    Location:39279
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
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